RESUMO
Abstract Giant axonal neuropathy is a rare autosomal recessive neurodegenerative disease. The condition is characterized by neurons with abnormally large axons due to intracellular filament accumulation. The swollen axons affect both the peripheral and central nervous system. A 6-year old female patient had been referred to a geneticist reporting problems with walking and hypotonia. At the age of 10, she became wheelchair dependent. Scanning electron microscopy of a curly hair classified it as pili canaliculi. GAN gene sequencing demonstrated mutation c.1456G>A (p.GLU486LYS). At the age of 12, the patient died due to respiratory complications. Dermatologists should be aware of this entity since hair changes are considered suggestive of GAN.
Assuntos
Humanos , Feminino , Criança , Neuropatia Axonal Gigante/patologia , Doenças do Cabelo/patologia , Microscopia Eletrônica de Varredura , Evolução Fatal , Neuropatia Axonal Gigante/complicações , Cabelo/patologia , Doenças do Cabelo/genética , MutaçãoRESUMO
Pitted keratolysis is a skin disorder that affects the stratum corneum of the plantar surface and is caused by Gram-positive bacteria. A 30-year-old male presented with small punched-out lesions on the plantar surface. A superficial shaving was carried out for scanning electron microscopy. Hypokeratosis was noted on the plantar skin and in the acrosyringium, where the normal elimination of corneocytes was not seen. At higher magnification (x 3,500) bacteria were easily found on the surface and the described transversal bacterial septation was observed.
Assuntos
Infecções por Corynebacterium/patologia , Dermatoses do Pé/microbiologia , Dermatoses do Pé/patologia , Dermatopatias Bacterianas/patologia , Adulto , Epiderme/patologia , Humanos , Ceratose/microbiologia , Ceratose/patologia , Masculino , Microscopia Eletrônica de VarreduraRESUMO
Abstract Pitted keratolysis is a skin disorder that affects the stratum corneum of the plantar surface and is caused by Gram-positive bacteria. A 30-year-old male presented with small punched-out lesions on the plantar surface. A superficial shaving was carried out for scanning electron microscopy. Hypokeratosis was noted on the plantar skin and in the acrosyringium, where the normal elimination of corneocytes was not seen. At higher magnification (x 3,500) bacteria were easily found on the surface and the described transversal bacterial septation was observed.
Assuntos
Humanos , Masculino , Adulto , Dermatopatias Bacterianas/patologia , Infecções por Corynebacterium/patologia , Dermatoses do Pé/microbiologia , Dermatoses do Pé/patologia , Microscopia Eletrônica de Varredura , Epiderme/patologia , Ceratose/microbiologia , Ceratose/patologiaRESUMO
Giant axonal neuropathy is a rare autosomal recessive neurodegenerative disease. The condition is characterized by neurons with abnormally large axons due to intracellular filament accumulation. The swollen axons affect both the peripheral and central nervous system. A 6-year old female patient had been referred to a geneticist reporting problems with walking and hypotonia. At the age of 10, she became wheelchair dependent. Scanning electron microscopy of a curly hair classified it as pili canaliculi. GAN gene sequencing demonstrated mutation c.1456G>A (p.GLU486LYS). At the age of 12, the patient died due to respiratory complications. Dermatologists should be aware of this entity since hair changes are considered suggestive of GAN.
Assuntos
Neuropatia Axonal Gigante/patologia , Doenças do Cabelo/patologia , Criança , Evolução Fatal , Feminino , Neuropatia Axonal Gigante/complicações , Cabelo/patologia , Doenças do Cabelo/genética , Humanos , Microscopia Eletrônica de Varredura , MutaçãoRESUMO
Superficial white onychomycosis is characterized by opaque, friable, whitish superficial spots on the nail plate. We examined an affected halux nail of a 20-year-old male patient with scanning electron microscopy. The mycological examination isolated Trichophyton mentagrophytes. Abundant hyphae with the formation of arthrospores were found on the nail's surface, forming small fungal colonies. These findings showed the great capacity for dissemination of this form of onychomycosis.
Assuntos
Dermatoses do Pé/microbiologia , Onicomicose/microbiologia , Dermatoses do Pé/patologia , Humanos , Masculino , Microscopia Eletrônica de Varredura , Onicomicose/patologia , Tinha/microbiologia , Tinha/patologia , Trichophyton/isolamento & purificação , Trichophyton/ultraestrutura , Adulto JovemRESUMO
AbstractSuperficial white onychomycosis is characterized by opaque, friable, whitish superficial spots on the nail plate. We examined an affected halux nail of a 20-year-old male patient with scanning electron microscopy. The mycological examination isolated Trichophyton mentagrophytes. Abundant hyphae with the formation of arthrospores were found on the nail's surface, forming small fungal colonies. These findings showed the great capacity for dissemination of this form of onychomycosis.
Assuntos
Humanos , Masculino , Adulto Jovem , Dermatoses do Pé/microbiologia , Onicomicose/microbiologia , Dermatoses do Pé/patologia , Microscopia Eletrônica de Varredura , Onicomicose/patologia , Tinha/microbiologia , Tinha/patologia , Trichophyton/isolamento & purificação , Trichophyton/ultraestruturaRESUMO
AbstractSelf-healing collodion baby is a well-established subtype of this condition. We examined a male newborn, who was covered by a collodion membrane. The shed membrane was examined with scanning electron microscopy. The outer surface showed a very compact keratin without the normal elimination of corneocytes. The lateral view of the specimen revealed a very thick, horny layer. The inner surface showed the structure of lower corneocytes with polygonal contour. With higher magnifications villous projections were seen in the cell membrane.
Assuntos
Humanos , Recém-Nascido , Masculino , Ictiose Lamelar/patologia , Microscopia Eletrônica de Varredura/métodos , Queratinócitos/patologiaRESUMO
The three-dimensional findings of the surface and from a cross section from a case of disseminated superficial porokeratois using scanning electron microscopy are reported. On the surface of the skin, irregular keratin with a serpiginous distribution was seen. A gross aspect of keratin in the hyperkeratotic wall was also observed and compared to the normal area, in which the release of corneocytes seemed normal. The cross-sectional imaging easily identified the cornoid lamella, with compact keratin surrounded by normal stratum corneum.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Imageamento Tridimensional/métodos , Poroceratose/patologia , Biópsia , Queratinas/análise , Microscopia Eletrônica de Varredura/métodos , Pele/patologiaRESUMO
The three-dimensional findings of the surface and from a cross section from a case of disseminated superficial porokeratois using scanning electron microscopy are reported. On the surface of the skin, irregular keratin with a serpiginous distribution was seen. A gross aspect of keratin in the hyperkeratotic wall was also observed and compared to the normal area, in which the release of corneocytes seemed normal. The cross-sectional imaging easily identified the cornoid lamella, with compact keratin surrounded by normal stratum corneum.
Assuntos
Imageamento Tridimensional/métodos , Poroceratose/patologia , Biópsia , Humanos , Queratinas/análise , Masculino , Microscopia Eletrônica de Varredura/métodos , Pessoa de Meia-Idade , Pele/patologiaRESUMO
Tinea nigra is a rare superficial mycosis caused by Hortaea werneckii. This infection presents as asymptomatic brown to black maculae mostly in palmo-plantar regions. We performed scanning electron microscopy of a superficial shaving of a tinea nigra lesion. The examination of the outer surface of the sample showed the epidermis with corneocytes and hyphae and elimination of fungal filaments. The inner surface of the sample showed important aggregation of hyphae among keratinocytes, which formed small fungal colonies. The ultrastructural findings correlated with those of dermoscopic examination - the small fungal aggregations may be the dark spicules seen on dermoscopy - and also allowed to document the mode of dissemination of tinea nigra, showing how hyphae are eliminated on the surface of the lesion.