Assuntos
DNA Viral/isolamento & purificação , Infecções por Herpesviridae/diagnóstico , Argentina/epidemiologia , Infecções por Herpesviridae/complicações , Infecções por Herpesviridae/epidemiologia , Humanos , Masculino , Sarcoma de Kaposi/complicações , Sarcoma de Kaposi/epidemiologia , Sarcoma de Kaposi/virologia , Homologia de Sequência do Ácido NucleicoRESUMO
A comparative study between 8 cases of trichinosis and 16 of typhoid fever is presented in this paper; all of them were attended in the INP during the period from 1970 to 1990. The diagnosis was established under epidemiologic, clinic and laboratory bases. The range of age of these patients was from 10 to 14 years, from low socioeconomic status; half of the cases had history of in take of infested pork meat. The most characteristic symptoms were: fever, myalgia and limitation of muscular movements. Leukocytosis in addition to eosinophilia were found in 7 cases. Correlation with indirect hemagglutination, CIEF positive test for Trichinella spiralis and biopsy of muscle was done. Thiabendozole therapy was utilized for treatment with satisfactory evolution, except in one case that developed progressive and fatal neurologic damage.
Assuntos
Triquinelose/diagnóstico , Fatores Etários , Criança , Diagnóstico Diferencial , Humanos , México/epidemiologia , Estudos Retrospectivos , Fatores Sexuais , Tiabendazol/uso terapêutico , Triquinelose/tratamento farmacológico , Triquinelose/epidemiologia , Triquinelose/transmissão , Febre Tifoide/diagnóstico , Febre Tifoide/epidemiologiaRESUMO
The quantitative determination of Interleukin-2 Receptor (sIL-2R) in the serum of patients with acute or chronic Chagas disease is compared with values found in normal individuals. The mean value of soluble IL-2R in patients with acute Chagas' disease was found to be 3,282 +/- 171 U/ml. The mean value of sIL-2R in serum samples from chronic chagasic patients was 511 +/- 207 U/ml, while in the control or "normal" group of persons the mean value for sIL-2R was 366 +/- 108 u/ml. In patients with early or acute infections with T. cruzi, the serum levels of sIL-2R was usually above 1000 u/ml. However, the correlation with anti-T. cruzi antibodies and levels of sIL-2R was not always directly proportional. Specific antibodies anti-T. cruzi in serum from chronic chagasic patients, shown at low or high levels, did not reveal a proportional correlation with serum levels of sIL-2R which tend to be significantly lower than in early or acute infections. It is considered that high values for sIL-2R are related with the parasite activity and its pathologic interaction with the host. It is possible that high levels of sIL-2R could serve as an indicator of early or acute Chagas' disease and be useful in assessment of disease conditions and response to therapy.
Assuntos
Doença de Chagas/sangue , Receptores de Interleucina-2/análise , Humanos , PanamáRESUMO
Se evalúan los niveles del Receptor soluble de interleucina-2 (sIL-2R) en sueros de pacientes que presentaban la forma clínica aguda o crónica de la Enfermedad de Chagas. El valor promedio de sIL-2R observado en pacientes en fase aguda fue de 511+-207 U/ml. y en sujetos controles fue de 366+-108 U/ml. Al correlacionar los datos obtenidos con los niveles de anticuerpos específicos en estos pacientes observamos que títulos altos de sIL-2R (1000 U/ml) se asociaron a la presencia de anticuerpos específicos anti-T. cruzi en infecciones recientes ó agudas. Esta correlación no fué estrictamente cuantitativa o directamente proporcional. En pacientes crónicos con niveles elevados de anticuerpos específicos anti-T. cruzi no mostraron correlación con la presencia de niveles séricos de sIL-2R, los cuales pueden ser bajos en casos crónicos de largo seguimiento. Consideramos que la presencia de niveles altos del receptor soluble de interleucina-2 se relaciona con la actividad del parásito y su interacción con el huésped. Finalmente, se discute la posibIlidad del uso del sIL-2R como marcador de fase aguda y su importancia como indicador de riesgo de enfermedad