RESUMO
OBJECTIVE: This study aimed to analyze the risk factors associated with diabetes mellitus (DM) among Brazilian adults. STUDY DESIGN: Cross-sectional study. METHODS: Data of 75,860 Brazilian adults (≥18 years) were collected using the Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey (Vigitel) (2020-2023). Variables assessed included self-reported medical diagnosis of DM, sociodemographic factors (sex, age, schooling, marital status) and DM risk factors (regular consumption of sweetened beverages (≥5 times/week), infrequent consumption of fruits and vegetables, and beans (<5 times/week), insufficient physical activity, prolonged screen time on cell phones, computers, tablets (CCT), and television (TV), smoking, heavy episodic drinking, excess weight, and obesity). Logistic regression models estimated crude and adjusted odds ratio (aOR) (adjusted for sociodemographic characteristics) for the association between the risk factors and the presence of DM. RESULTS: The overall prevalence of self-reported DM in the population was 9.2%. There was a lower chance of regular consumption of sweetened beverages (aOR 0.79; 95% CI: 0.65-0.97) and heavy episodic drinking (aOR 0.77; 95% CI: 0.65-0.93) and a greater chance of insufficient physical activity (aOR 1.40; 95% CI: 1.25-1.55), prolonged TV screen time (aOR 1.22; 95% CI: 1.09-1.36), excess weight (aOR 1.62; 95% CI: 1.44-1.82) and obesity (aOR 1.87; 95% CI: 1.67-2.10) among individuals with DM. CONCLUSION: There was a lower chance of regular consumption of sweetened beverages and heavy episodic drinking among individuals with DM and a greater chance of insufficient physical activity, prolonged TV screen time, excess weight, and obesity, among that.
Assuntos
Diabetes Mellitus , Humanos , Masculino , Adulto , Feminino , Brasil/epidemiologia , Pessoa de Meia-Idade , Estudos Transversais , Fatores de Risco , Diabetes Mellitus/epidemiologia , Adulto Jovem , Adolescente , Idoso , Prevalência , Exercício Físico , Fatores Socioeconômicos , Tempo de Tela , Obesidade/epidemiologia , Comportamento Sedentário , Fatores SociodemográficosRESUMO
The aim of the study was to describe location, sonographic characteristics and measures of the stomach and small intestine of equines at different ages. Abdominal ultrasonography was performed on 88 healthy equines of either sex, aged 1, 7 and 15 days, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 months and 1, 3 and 5 years, with 20 animals per group. Location, characteristics and measurements of stomach, duodenum and jejunum were evaluated. Descriptive statistics were performed for each measurement and the percentile for each age was analyzed. The work showed the growth and characteristics of the organs evaluated over time. Adult animals showed a minimum of 4 duodenal movements per minute. It was possible to locate the organs evaluated in all animals. The detailed ultrasound examination of these organs allowed gathering information that could be used to assist in the care of future patients.
O objetivo deste estudo foi descrever localização topográfica, características e medidas ultrassonográficas de estômago e intestino delgado de equinos em diferentes idades. Foi realizado um exame ultrassonográfico abdominal em 20 equinos saudáveis de ambos os sexos, com idades de um, sete e 15 dias, um, dois, três, quatro, cinco, seis, sete, oito, nove, 10 e 11 meses e um, três e cinco anos. A localização, as características e as medidas de estômago, duodeno e jejuno foram avaliadas. Foi realizada a estatística descritiva para cada medida e analisado o percentil para cada idade. O trabalho mostrou o crescimento e as características dos órgãos avaliados ao longo do tempo. Animais adultos apresentaram um mínimo de quatro movimentos por minuto de duodeno. Foi possível localizar os órgãos avaliados em todos os animais. O exame ultrassonográfico detalhado desses órgãos permitiu agrupar informações que poderão ser usadas para auxiliar no atendimento a futuros pacientes.
Assuntos
Animais , Estômago/anatomia & histologia , Ultrassonografia/veterinária , Cavalos/anatomia & histologia , Cavalos/crescimento & desenvolvimento , Intestino Delgado/anatomia & histologiaRESUMO
This study aimed to report the prevalence of diseases in foals, patients at the Hospital Veterinário de Grandes Animais, Universidade Federal de Lavras (HVGA-UFLA), and its association with deaths and possible failures in the transfer of passive immunity (FTIP) via colostrum. Data were obtained from clinical records of horses aged between 0 and 3 months, admitted to the HVGA between January/2014 and December/2018. Descriptive analyzes of the diseases and organ systems affected were performed, as well as univariate analyzes with chi-square or Fisher's exact tests, identifying possible associations between FTIP, infectious diseases and other factors. No significant relationships were found between FTIP and infectious disease, meconium retention, sepsis, or death. However, it was shown that animals weighing between 10 and 30kg were 29.333 times more likely (95% confidence interval 1.734 - 505.951) to die than those weighing between 30.1 and 130kg. Therefore, it can be concluded that low weight is a very relevant risk factor, which may be related to the failure of postural reflexes and, consequently, to the inability to ingest colostrum, impairing the ability to respond to infectious agents.
Este trabalho objetivou relatar a prevalência de enfermidades em potros, pacientes do Hospital Veterinário de Grandes Animais da Universidade Federal de Lavras (HVGA-UFLA), e sua associação com óbitos e possíveis falhas na transferência de imunidade passiva (FTIP) via colostro. Os dados foram obtidos pelas fichas clínicas de equinos com idade entre 0 e 6 meses, internados no HVGA entre janeiro/2014 e dezembro/2018. Foram realizadas análises descritivas das enfermidades e os sistemas orgânicos acometidos, além de análises univariadas, com testes de qui-quadrado ou exato de Fisher, identificando possíveis associações entre FTIP, enfermidades infecciosas e outros fatores, com p menor que 0,05 e intervalo de confiança (IC) de 95%. Não foram encontradas relações significativas entre FTIP e enfermidades infecciosas, retenção de mecônio, sepse ou morte. No entanto, foi demonstrado que animais com peso entre 10 e 30kg tiveram 29,333 vezes (IC 95% 1,734 - 505,951) mais chance de virem a óbito que aqueles com peso entre 30,1 e 130kg. Portanto, pode-se concluir que o baixo peso é um fator de risco bastante relevante, que pode estar relacionado à falha de reflexos posturais e consequentemente, à incapacidade de ingerir colostro, prejudicando a capacidade de resposta a agentes infecciosos.
Assuntos
Animais , Fatores de Risco , Imunização Passiva , Colostro , Cavalos/imunologiaRESUMO
DNA replication, together with repair mechanisms and cell cycle control, are the most important cellular processes necessary to maintain correct transfer of genetic information to the progeny. These processes are well conserved throughout the Eukarya, and the genes that are involved provide essential information for understanding the life cycle of an organism. We used computational tools for data mining of genes involved in these processes in the pathogenic fungus Paracoccidiodes brasiliensis. Data derived from transcriptome analysis revealed that the cell cycle of this fungus, as well as DNA replication and repair, and the recombination machineries, are highly similar to those of the yeast Saccharomyces cerevisiae. Among orthologs detected in both species, there are genes related to cytoskeleton structure and assembly, chromosome segregation, and cell cycle control genes. We identified at least one representative gene from each step of the initiation of DNA replication. Major players in the process of DNA damage and repair were also identified.
Assuntos
Humanos , Ciclo Celular/genética , DNA Fúngico/genética , Paracoccidioides/genética , Recombinação Genética/genética , Reparo do DNA/genética , Replicação do DNA/genética , Ciclo Celular/fisiologia , Genes Fúngicos/genética , Mutação/genética , Paracoccidioides/citologia , Recombinação Genética/fisiologia , Reparo do DNA/fisiologia , Replicação do DNA/fisiologia , Transcrição Gênica/genéticaRESUMO
Acute renal failure is one the most common systemic complications after snakebite, however, its pathogenesis remains obscure. In this study we evaluated the renal effects of Bothrops moojeni venom and its myotoxins (Bmtx-I and BmtxII) in rat isolated perfused kidneys. The myotoxins were purified by ion-exchange chromatography and reverse phase HPLC. The whole venom (10 microg/ml) and myotoxins (5 microg/ml) were added to the perfusion system 30 min after the beginning of each perfusion. The renal effects were compared to a control group perfused with modified Krebs-Henseleit solution alone. B. moojeni venom decreased the perfusion pressure (PP), renal vascular resistance (RVR), and the percent sodium, potassium and chloride tubular transport (%TNa(+), %TK(+), %TCl(-)). In contrast, the venom increased the urinary flow (UF), glomerular filtration rate (GFR), and the sodium, potassium and chloride excretion (ENa(+), EK(+), ECl(-)). The renal effects of myotoxin I was very similar to those of the whole venom, but there was an increase rather than a decrease in the PP and RVR. Myotoxin II had no effect on renal physiology, except for a transient decrease in %TK(+). In conclusion, B. moojeni venom caused intense alterations in renal physiology, including a drop in vascular resistance associated with diuresis, natriuresis and kaliuresis. Bmtx-I had an opposite effect when compared to whole venom, showed in the parameters of PP and RVR. Bmtx-II had a mild effect in %TK(+). The apparent inability of Bmtx-II to induce the renal effect similarly to Bmtx-I should be explained by the absence in the Bmtx-II of the C-terminal lysine rich region.