RESUMO

Sixteen patients with mild or moderate essential hypertension received 1 to 8 mg/day of doxazosin (mean daily dose, 2.7 mg). Blood pressure reduction (supine and standing) was highly significant (p less than 0.001), and no significant changes in heart rate were observed. A significant reduction (p less than 0.01) in left ventricular mass was seen without a change in left ventricular systolic function. All side effects were mild, and only one patient withdrew from the study.

Assuntos

Anti-Hipertensivos/uso terapêutico , Cardiomegalia/diagnóstico por imagem , Ecocardiografia , Hipertensão/tratamento farmacológico , Prazosina/análogos & derivados , Adulto , Cardiomegalia/tratamento farmacológico , Doxazossina , Feminino , Humanos , Hipertensão/diagnóstico por imagem , Masculino , Prazosina/uso terapêutico