RESUMO
INTRODUCTION: A significant peripheral blood plasmacytosis is a rare finding associated with viral infections. We reported five consecutive cases of dengue virus infection, with circulating plasma cells. CASE REPORTS: Three women and two men, aged 26 to 75 years, had returned from French West Indies less than one week before the onset of the symptoms (mean: 2.5 days). The transient blood plasmacytosis was variable in intensity (0.1 to 0.8 G/L) with a maximal level between the fourth and the seventh day following the onset of the symptoms, and was associated in four patients, with activated lymphocytes and lympho-plasma cells. CONCLUSION: Reactive plasmacytosis during dengue fever is common and probably underestimated because it is transient and only identified by careful microscopic examination of a blood smear. Plasmacytosis could be explained by the intensity of the immunological response and the production of large amount of interleukins.
Assuntos
Dengue/sangue , Dengue/epidemiologia , Plasmócitos/patologia , Adulto , Idoso , Dengue/complicações , Dengue/patologia , Feminino , Hemólise/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Viagem , Índias OcidentaisRESUMO
INTRODUCTION: Dengue fever is the main emerging vector-borne disease worldwide. It was estimated that 40% of the world population is at risk. A potential vector (Aedes albopictus) is present in four French departments of the southeast area of metropolitan France. METHOD: The authors tried to document the number of imported cases of dengue diagnosed from 2001 to 2006, inclusive, as well as their main features. RESULTS: Between 12 and 28 cases of imported dengue were diagnosed every month during that period (eight to 18 cases per month except for years 2001-2002 during which an important dengue epidemic was documented in the French West Indies). Nearly 40% of the cases were imported between June and September during which the vector is active in the metropolitan area. CONCLUSION: This data underlines the strong and close link between the endemic zones of the French territory (French West Indies and Guyana) and the risk of imported cases to metropolitan France. The identification of this "importation track" entails strengthening the system for detecting and managing imported dengue cases in metropolitan France when a dengue epidemic is detected in the French West Indies.
Assuntos
Dengue/epidemiologia , Viagem , Aedes , África , Animais , Sudeste Asiático , França/epidemiologia , Humanos , Índia , Madagáscar , Estações do Ano , América do Sul , Sri Lanka , População UrbanaRESUMO
Dengue fever is a widespread disease that can occur outside tropical areas. Several thousand French military personnel are exposed to this infectious risk each year and exposure is expected to rise with the creation of a professional army and the increasing number of foreign missions. As a result, dengue fever has become a major priority for the Armed Services Health Corps (ASHC). A system of epidemiological surveillance based on the active participation of all military physicians has been designed by the ASHC to collect and analyze all data relevant to cases of dengue fever involving French military personnel stationed overseas or at home. The purpose of this study is to present data compiled for the period from 1996 to 1999. Analysis of these data demonstrated that the incidence of dengue fever peaked in 1997 due to epidemic outbreaks occurring in French Polynesia and Martinique. In response to these outbreaks control measures were adapted especially in regard to vector control. This study shows that the system of surveillance implemented by the ASHC is an effective but still perfectible tool.
Assuntos
Dengue/epidemiologia , Surtos de Doenças , Exposição Ambiental , Militares , Adulto , Animais , França/etnologia , Humanos , Incidência , Insetos Vetores , Masculino , Martinica/epidemiologia , Polinésia/epidemiologia , Medição de Risco , ViagemRESUMO
Severe forms of dengue fever, dengue haemorrhagic fever, and dengue shock syndrome, were not prominent in the Americas until the epidemic of Cuba in 1981. Since that time, they have spread to other countries in Central and South America, correlating with the spread of dengue type 2 viruses related to Southeast Asian strains. We report here the complete genomic sequence of a dengue type 2 virus isolated during the epidemic in La Martinique in 1998. This constitutes the first complete genetic characterization of a dengue virus strain from French West Indies, and also the first molecular identification in this region of a dengue 2 strain phylogenetically related to the emerging American type 2 dengue viruses.
Assuntos
Vírus da Dengue/genética , Dengue/virologia , Genoma Viral , Substituição de Aminoácidos/genética , Doenças Transmissíveis Emergentes/epidemiologia , Doenças Transmissíveis Emergentes/virologia , Dengue/epidemiologia , Vírus da Dengue/química , Vírus da Dengue/classificação , Humanos , Filogenia , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Análise de Sequência , Sorotipagem , Índias Ocidentais/epidemiologiaRESUMO
Yellow fever was presumably imported to the Americas from West-Africa from the 16th to the 19th century. American and African genotypes of the virus are distinguishable, indicating separate evolution in different vector/host cycles. The complete nucleotide sequence of the yellow fever virus strain TRINID79A, isolated in Trinidad in 1979, has been established. It exhibits extensive homology with those of current West-African strains and attenuated strain FNV. However, a unique deletion of the 3' non-coding region (NCR) of the viral RNA has been identified. It indicates that RYF1 and RYF2 repeated sequences of the 3' NCR are not necessary to the replication of the virus.
Assuntos
Genoma Viral , Filogenia , Vírus da Febre Amarela/genética , Regiões 3' não Traduzidas/genética , Sequência de Bases , DNA Complementar , Dados de Sequência Molecular , RNA Viral/genética , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Trinidad e Tobago , Vírus da Febre Amarela/classificaçãoRESUMO
Dengue has become a major public health problem in intertropical areas where an estimated 60 million new cases and 30,000 deaths occur annually. The causative agent is transmitted by the bite of Aedes mosquitoes which are the main and perhaps only reservoir of the disease. In addition to increasing incidence clinical manifestations of dengue have changed over the last 40 years. An increasing number of reported cases involve hemorrhage, shock, and other severe complications especially in Southeast Asia, northern regions of South America, and the Caribbean. Some of the same factors responsible for these changes are probably implicated in the development of other emerging viral diseases.