RESUMO

Introducción: El Síndrome Hipertensivo del Embarazo (SHE) es el conjunto de condiciones patológicas derivadas del alza de presión arterial mantenida originadas antes y/o durante el curso de un embarazo. En ocasiones requiere tratamiento hospitalario. El objetivo del estudio es determinar la tasa de egreso hospitalario (TEH) por complicaciones del SHE durante el 2018-2021 en Chile. Materiales y métodos: Estudio descriptivo tipo transversal de las complicaciones por SHE en el periodo 2018-2921 en Chile según grupo etario y días de estadía hospitalaria (n=12.006). Datos obtenidos del departamento de estadística e información en salud. Se calculó TEH. No requirió aprobación del comité de ética. Resultados: La Preeclampsia tuvo más TEH con 61,48 por cada 100.000 habitantes, afectó más a mujeres de 20 a 44 años con 74.03 por 100.000 habitantes. Las complicaciones del SHE reportaron un promedio de 6,4 días de hospitalización. El Síndrome de HELLP registró más días de hospitalización con 7,2 días. Discusión: El envejecimiento poblacional, la migración, el sobrepeso-obesidad podrían influir en mayores TRH por preeclampsia. Se reportó mayores TEH de preeclampsia en mujeres de 20 a 44 años. Esto se debe posiblemente por factores cardiovasculares, maternidad tardía y la hipertensión crónica. El Síndrome de HELLP implica peor pronóstico y reportó mayores días hospitalización debido al manejo médico. Discusión: Hay escasas estadísticas nacionales sobre TEH en relación a SHE. La edad, el riesgo cardiovascular y fenómenos epidemiológicos ofrecen posibles líneas investigativas. Más estudios son requeridos para dilucidar los factores que desencadenan sus complicaciones.

Introduction: The Hypertensive Syndrome of Pregnancy (SHE) is the set of pathological conditions derived from the increase in sustained blood pressure originating before and/or during the course of a pregnancy. Sometimes it requires hospital treatment. The objective of the study is to determine the rate of hospital discharge (TEH) due to complications of EHS during 2018-2021 in Chile. Materials and Methods: Descriptive transversal type of study about the complications of hypertensive pregnancy syndrome during the period from 2018 to 2021 according to age range and number of days in the hospital (n=12.006). Data obtained from the health statistics and information department, which did not require approval of the ethics committee. Results: PE had a higher TEH with 61.48 out of 100,000 people, affecting more women aged 20 to 44 years with 74.03 per 100,000 inhabitants. Complications of hypertensive pregnancy syndrome reported an average of 6.4 hospitalization days. The HELLP syndrome had more days with a quantity of 7.2. Discussion: Population aging, migration, and overweight-obesity might influence the increase in TEH/PE. Higher TEH of PE was reported in women aged 20 to 44 years, possibly due to cardiovascular factors, late maternity, and chronic hypertension. The HELLP syndrome implies a worse prognosis and reported more days at the hospital due to medical treatment. Conclusion: There are few national statistics on TEH in relation to SHE. Age, cardiovascular risk, and epidemiological phenomena offer possible lines of investigation. More studies are required to elucidate the factors that trigger its complications.

Assuntos

RESUMO

Intracellular calcium levels ([Ca2+]i) and glucose uptake are central to cardiomyocyte physiology, yet connections between them have not been studied. We investigated whether insulin regulates [Ca2+]i in cultured cardiomyocytes, the participating mechanisms, and their influence on glucose uptake via SLC2 family of facilitative glucose transporter 4 (GLUT4). Primary neonatal rat cardiomyocytes were preloaded with the Ca2+ fluorescent dye fluo3-acetoxymethyl ester compound (AM) and visualized by confocal microscopy. Ca2+ transport pathways were selectively targeted by chemical and molecular inhibition. Glucose uptake was assessed using [3H]2-deoxyglucose, and surface GLUT4 levels were quantified in nonpermeabilized cardiomyocytes transfected with GLUT4-myc-enhanced green fluorescent protein. Insulin elicited a fast, two-component, transient increase in [Ca2+]i. Nifedipine and ryanodine prevented only the first component. The second one was reduced by inositol-1,4,5-trisphosphate (IP3)-receptor-selective inhibitors (xestospongin C, 2 amino-ethoxydiphenylborate), by type 2 IP3 receptor knockdown via small interfering RNA or by transfected Gßγ peptidic inhibitor ßARKct. Insulin-stimulated glucose uptake was prevented by bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid-AM, 2-amino-ethoxydiphenylborate, and ßARK-ct but not by nifedipine or ryanodine. Similarly, insulin-dependent exofacial exposure of GLUT4-myc-enhanced green fluorescent protein was inhibited by bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid-AM and xestospongin C but not by nifedipine. Phosphatidylinositol 3-kinase and Akt were also required for the second phase of Ca2+ release and GLUT4 translocation. Transfected dominant-negative phosphatidylinositol 3-kinase γ inhibited the latter. In conclusion, in primary neonatal cardiomyocytes, insulin induces an important component of Ca2+ release via IP3 receptor. This component signals to glucose uptake via GLUT4, revealing a so-far unrealized contribution of IP3-sensitive Ca2+ stores to insulin action. This pathway may influence cardiac metabolism in conditions yet to be explored in adult myocardium.

Assuntos

RESUMO

We report a 43 years old female who developed an intense precordial pain and arterial hypotension. The patient was admitted to the emergency room in cardiogenic shock. An emergency angiography revealed a total occlusion of the left main coronary artery. An endoluminal coronary angioplasty with the placement of two stents was performed and coronary reperfusion TIMI III was achieved. The patient had a good evolution and one month later, a surgical revascularization was done, to avoid new occlusions. She was discharged in good conditions and in functional capacity I

Assuntos

RESUMO

The case of a 42 years old woman, who had laparoscopic hysterectomy and seven hours after presented with a convulsive crisis and later a coma status, secondary to hyponatremia. Hyponatremia causes, are discussed, as well as its relationship with syndrome of inadequate secretion of antidiuretic hormone, diagnosis, management, prognosis factors and risk.

Assuntos

RESUMO

A case of a 34 years old woman with primary sterility secondary to multiple myomatosis, is presented. Any other sterility factor was ruled out. First, she went on laparotomy for multiple myoma resection but two of these were left. The cornual myoma couldn't be removed because the high risk of salpinx damage. The other one was a 3 cm. intracavitary tumor. After four months on leuprolide acetate therapy an hysteroscopic myomectomy was performed. The next menstrual cycle pregnancy was achieved.

Assuntos

Assuntos

RESUMO

The results of the first twelve cases of Laparoscopic Assisted Vaginal Hysterectomy, are presented. The indications for hysterectomy were myomatosis, suspicion of adenomyosis and endometriosis. The surgical technique is described in detail in which a combination of bipolar Kleppinger forceps and reusable scissors were employed. There were two intraoperative accidents. One subcutaneous emphysema of the left half of the abdominal wall, thorax, neck, face and upper limb. The second case was a damage to a branch of the left epigastric artery. The average time was 4 hours 31 minutes which includes 9 patients to which another surgical procedure was practiced. There was no significant bleeding in any of the patients. The postoperative complications were 1 hyponatremia that needed the use of an Intensive Care Unit and the other was periumbilical hematoma of 3 cm. of diameter. The patient was discharged on the one to three postoperative day with an average of two days. The average hospital fee was 35% higher than an abdominal hysterectomy. All the surgery were videotaped and later viewed by the patients. It was concluded that the laparoscopic assistance that is offered to the vaginal hysterectomy is particularly advantageous for hysterectomy especially in the cases where absence of genital prolapse, when uni or bilateral Adnexectomy is required, previous past history of abdomino-pelvic surgery, endometriosis and adhesions. This procedure should be included in the armamentarium of the Gynecological Surgeons but only after and appropriate training.

Assuntos

Assuntos

Assuntos