RESUMO
The stability of pilocarpine and pilocarpine-timolol eyedrop preparations available on the Argentine market was studied. A high-performance liquid chromatographic method that allows the estimation of pilocarpine in the presence of degradation products was used for the study according to the preestablished design. It was found that pilocarpine solutions are stable, while pilocarpine in association with timolol shows significant degradation.
Assuntos
Soluções Oftálmicas/química , Parassimpatomiméticos/química , Pilocarpina/química , Timolol/química , Argentina , Cromatografia Líquida de Alta Pressão , Interações Medicamentosas , Estabilidade de Medicamentos , Soluções/química , Simpatolíticos/químicaRESUMO
This study's main object was the determination of substances, by means of high-performance liquid chromatography (HPLC), that are related to enalapril maleate in medicinal tablets. The research was on products containing a 20 mg active principle with a 12-month delta t and on those batches near their expiration date with an enalapril maleate concentration of 10, 5, and 2.5 mg.