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BACKGROUND: To describe demographic and clinicopathological aspects of a South-American cohort of incipient oral squamous cell carcinoma patients. MATERIAL AND METHODS: A cross-sectional, observational study was performed to assess demographic and clinicopathological characteristics of incipient oral squamous cell carcinoma patients from 6 South-American institutions. RESULTS: One hundred and seven patients within the histopathological spectrum of incipient oral squamous cell carcinoma (in-situ and microinvasive) were included. Fifty-eight (54.2%) patients were men with a mean age of 60.69 years. Forty-nine (45.8%) and thirty-nine (36.5%) patients had history of tobacco and alcohol use, respectively. Clinically, most of the lesions were plaques (82.2%), ≥ 2 cm in extension (72%), affecting the lateral border of the tongue (55.1%), and soft palate (12.1%) with a mixed (white and red) appearance. Eighty-two (76.7%) lesions were predominantly white and 25 (23.3%) predominantly red. CONCLUSIONS: To the best of our knowledge, this is the largest cohort of incipient oral squamous cell carcinoma patients, which raises awareness of clinicians' inspection acuteness by demonstrating the most frequent clinical aspects of this disease, potentially improving oral cancer secondary prevention strategies.

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Com o objetivo de avaliar a qualidade dos ovos de codornas alimentadas com diferentes aditivos em duas fases de produção, 360 codornas foram distribuídas em um delineamento inteiramente ao acaso, em esquema de parcela subdividida no tempo (de nove até 23 e de 24 até 39 semanas de idade), com cinco tratamentos e oito repetições de nove aves cada, organizados da seguinte forma: controle, antibiótico, prebiótico, probiótico e simbiótico. As variáveis analisadas foram: unidade Haugh, índice de gema, porcentagem dos componentes do ovo, espessura de casca medida pelo micrômetro e pelo MEV. O fornecimento dos aditivos no segundo período aumentou a unidade Haugh e nos dois períodos avaliados proporcionou aumento da porcentagem de gema e de casca e da espessura da casca e de suas membranas. A inclusão dos aditivos foi mais eficiente em aumentar o peso dos ovos e a porcentagem de gema e de casca no segundo período. A espessura da casca (MEV) melhorou após inclusão de antibiótico e simbiótico na ração no segundo período. A inclusão de aditivos na ração melhora a qualidade dos ovos de codornas durante toda a fase produtiva. Antibiótico e simbiótico são mais eficazes em melhorar a espessura da casca dos ovos produzidos durante o segundo período produtivo.(AU)

To evaluate the quality of eggs of quails fed with different additives in two stages of the productive period, 360 quails were distributed in a completely randomized design in a split plot scheme in time (9 to 23 and 24 to 39 weeks of age) with five treatments and eight repetitions of nine birds each, organized as follows: control, antibiotic, prebiotic, probiotic, and symbiotic. The analyzed variables were: Haugh unit, yolk index, percentage of egg components, shell thickness measured by the micrometer and the SEM. The supply of additives in the second period increased Haugh units, and in both periods provided an increase in the percentage of yolk and shell and improved the thickness of the shell and its membranes. The inclusion of additives was more effective in promoting weight gain in eggs and the percentage of egg yolk and egg shell from 24 to 39 weeks of age. The shell thickness (SEM) improved after inclusion of antibiotic and symbiotic in feed in the second period. The addition of additives in food improved the quality of Japanese quail egg throughout the productive period. Antibiotics and symbiotics proved to be more effective in improving shell thickness of the eggs produced in the second productive period.(AU)

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Com o objetivo de avaliar a qualidade dos ovos de codornas alimentadas com diferentes aditivos em duas fases de produção, 360 codornas foram distribuídas em um delineamento inteiramente ao acaso, em esquema de parcela subdividida no tempo (de nove até 23 e de 24 até 39 semanas de idade), com cinco tratamentos e oito repetições de nove aves cada, organizados da seguinte forma: controle, antibiótico, prebiótico, probiótico e simbiótico. As variáveis analisadas foram: unidade Haugh, índice de gema, porcentagem dos componentes do ovo, espessura de casca medida pelo micrômetro e pelo MEV. O fornecimento dos aditivos no segundo período aumentou a unidade Haugh e nos dois períodos avaliados proporcionou aumento da porcentagem de gema e de casca e da espessura da casca e de suas membranas. A inclusão dos aditivos foi mais eficiente em aumentar o peso dos ovos e a porcentagem de gema e de casca no segundo período. A espessura da casca (MEV) melhorou após inclusão de antibiótico e simbiótico na ração no segundo período. A inclusão de aditivos na ração melhora a qualidade dos ovos de codornas durante toda a fase produtiva. Antibiótico e simbiótico são mais eficazes em melhorar a espessura da casca dos ovos produzidos durante o segundo período produtivo.(AU)

To evaluate the quality of eggs of quails fed with different additives in two stages of the productive period, 360 quails were distributed in a completely randomized design in a split plot scheme in time (9 to 23 and 24 to 39 weeks of age) with five treatments and eight repetitions of nine birds each, organized as follows: control, antibiotic, prebiotic, probiotic, and symbiotic. The analyzed variables were: Haugh unit, yolk index, percentage of egg components, shell thickness measured by the micrometer and the SEM. The supply of additives in the second period increased Haugh units, and in both periods provided an increase in the percentage of yolk and shell and improved the thickness of the shell and its membranes. The inclusion of additives was more effective in promoting weight gain in eggs and the percentage of egg yolk and egg shell from 24 to 39 weeks of age. The shell thickness (SEM) improved after inclusion of antibiotic and symbiotic in feed in the second period. The addition of additives in food improved the quality of Japanese quail egg throughout the productive period. Antibiotics and symbiotics proved to be more effective in improving shell thickness of the eggs produced in the second productive period.(AU)

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We present direct detection constraints on the absorption of hidden-photon dark matter with particle masses in the range 1.2-30 eV c^{-2} with the DAMIC experiment at SNOLAB. Under the assumption that the local dark matter is entirely constituted of hidden photons, the sensitivity to the kinetic mixing parameter κ is competitive with constraints from solar emission, reaching a minimum value of 2.2×10^{-14} at 17 eV c^{-2}. These results are the most stringent direct detection constraints on hidden-photon dark matter in the galactic halo with masses 3-12 eV c^{-2} and the first demonstration of direct experimental sensitivity to ionization signals <12 eV from dark matter interactions.

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BACKGROUND: Brazil requires the performance of both a test for hepatitis B surface antigen (HBsAg) and a test for antibodies to the core of hepatitis B for blood donor screening. Blood centres in regions of high HBV endemicity struggle to maintain adequate stocks in face of the high discard rates due to anti-HBc reactivity. We evaluated the potential infectivity of donations positive for anti-HBc in search of a rational approach for the handling of these collections. STUDY DESIGN AND METHODS: We tested anti-HBc reactive blood donations from the state of Amazonas for the presence of HBV DNA and for titres of anti-HBs. The study population consists of village-based donors from the interior of Amazonas state. RESULTS: Among 3600 donations, 799 were anti-HBc reactive (22·2%). We were able to perform real-time PCR for the HBV S gene on specimens from 291 of these donors. Eight of these samples were negative for HBsAg and positive for HBV DNA and were defined as occult B virus infections (2·7%). Six of those eight specimens had anti-HBs titres above 100 mIU/ml, indicating the concomitant presence of the virus with high antibody titres. CONCLUSION: A small proportion of anti-HBc reactive donors carry HBV DNA and anti-HBs testing is not useful for predicting viremia on them. This finding indicates the possibility of HBV transmission from asymptomatic donors, especially in areas of high HBV prevalence. Sensitive HBV DNA nucleic acid testing may provide another level of safety, allowing eventual use of anti-HBc reactive units in critical situations.

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