RESUMO
BACKGROUND: Breast Cancer (BCa) is the most common malignant tumour in Mexican women. In BCa, several studies have linked ß2-adrenergic receptor activation with increased tumour growth and progression as related with Epinephrine-NorEpinephrine (E-NE) stimulation. The aim of this study was to describe Beta-Blocker (BB) treatment related with reduction of the risk of metastasis in Mexican patients with BCa. MATERIALS AND METHODS: We collected data of 120 patients seen at the High-Specialty Naval General Hospital in Mexico City (HOSGENAES), all of these with a histopathological diagnosis of BCa. Four groups of patients were divided as follows: without Systemic Arterial Hypertension (SAH); with SAH treatment with non-selective BB; with SAH treatment with selective BB, and with SAH treatment with other antihypertensive drugs. Chi-square, Mantel- Haenszel, Student t, and ANOVA tests were performed for data analysis. RESULTS: On average, patients were 54.8±11.8 years of age. Risk factors such as smoking and consuming alcohol exhibited a frequency of 33 and 36.5% respectively. Clinical stages III- IV were found in 50% of patients, while, 30% of patients had arterial hypertension (n=29 and N=96, respectively) and 17.5% used BB. One hundred percent of patients with arterial hypertension treated with BB for ß1 - and ß2 -adrenergic-receptors did not present metastasis globally, but patients treated with ß1 BB presented 30% of metastasis while patients treated with no BB or without SAH had around 70% of metastasis. CONCLUSIONS: In Mexican patients with BCa and SAH treated with non-selective (ß1- and ß2-adrenergic receptors) BB, a decrease in the risk for metastasis was observed at the time of diagnosis.
Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Carcinoma Ductal de Mama/tratamento farmacológico , Carcinoma Lobular/tratamento farmacológico , Hipertensão/tratamento farmacológico , Comportamento de Redução do Risco , Adulto , Idoso , Idoso de 80 Anos ou mais , Anti-Hipertensivos/uso terapêutico , Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/secundário , Carcinoma Lobular/secundário , Feminino , Seguimentos , Humanos , Hipertensão/epidemiologia , Hipertensão/patologia , Metástase Linfática , México , Pessoa de Meia-Idade , Invasividade Neoplásica , Estadiamento de Neoplasias , PrognósticoRESUMO
We studied the effects of high doses of pentobarbital (PB) and carbamazepine (CBZ) on electrolyte levels and pH in an epileptic animal model. Pentobarbital decreased Ca2+ and Na+ levels without pentylenetetrazole (PTZ). After this, Ca2+ and Na+ levels continued to decrease except when CBZ was used, which preserved the Ca2+ levels PTZ may have opposed effects on PB. Our results suggest that PB causes changes in electrolyte levels and pH, but these changes are diminished by CBZ.
Assuntos
Eletrólitos/metabolismo , Concentração de Íons de Hidrogênio/efeitos dos fármacos , Hipnóticos e Sedativos/farmacologia , Pentobarbital/farmacologia , Convulsões/metabolismo , Animais , Anticonvulsivantes/farmacologia , Anticonvulsivantes/uso terapêutico , Cálcio/metabolismo , Carbamazepina/farmacologia , Carbamazepina/uso terapêutico , Modelos Animais de Doenças , Interações Medicamentosas , Hipnóticos e Sedativos/uso terapêutico , Masculino , Pentobarbital/uso terapêutico , Pentilenotetrazol , Ratos , Ratos Wistar , Convulsões/induzido quimicamente , Convulsões/tratamento farmacológico , Sódio/metabolismo , Estatísticas não ParamétricasRESUMO
AIMS: In children with articulatory defects it is important to evaluate the central auditory level. We compared the results of the interwave intervals of brainstem auditory evoked potentials (BAEP) at 80 dB SPL (sound pressure level) and the latencies of the waves of long latency auditory evoked potentials (LLAEP) (vertex) in 5-year-old children with articulatory defects for /l/, /r/, /rr/ and /s/, and in controls. SUBJECTS AND METHODS: Fifty cases of 5-year-old children of both sexes were evaluated; 25 had articulatory defects and 25 with no articulatory defects were used as controls. Melgar's articulation test was applied to both groups. The following aspects were considered in the two groups: normal bilateral audition by means of tone audiometry, tympanometry and the revised Wechsler Intelligence Scale for preschool and primary school children, which were normal; there was no history of neurological damage. Interwave intervals for waves I-III, I-V and III-V of the BAEP and the latencies of the LLAEP (vertex) were evaluated. RESULTS: Data were analysed using SPSS 12, and descriptive statistics and Student's t test were carried out to appraise the differences between the two groups. No differences were found between the control group and the study group. CONCLUSIONS: It is important to determine whether children with articulatory defects have alterations in the auditory receptor or in their central auditory function. It can be concluded that the variables analysed in the two groups behave in the same way; no significant differences were found, which suggests that neither the auditory receptor nor the central auditory function are affected in the study group. Further studies are to be conducted to investigate the meaning of the difference in central nervous conduction between the two afferences in the study group.
Assuntos
Transtornos da Articulação/fisiopatologia , Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia , Transtornos da Audição/fisiopatologia , Fonética , Percepção Auditiva/fisiologia , Pré-Escolar , Feminino , Humanos , Idioma , MasculinoRESUMO
INTRODUCTION: In this study, a new dichotic digit test in Spanish (NDDTS) was applied in order to identify auditory laterality. We also evaluated body laterality and spatial location using the Subirana test. SUBJECTS AND METHODS: Both the dichotic test and the Subirana test for body laterality and spatial location were applied in a group of 40 children with dyslexia and in a control group made up of 40 children who were paired according to age and gender. The results of the three evaluations were analysed using the SPSS 10 software application, with Pearson's chi-squared test. RESULTS: It was seen that 42.5% of the children in the group of dyslexics had mixed auditory laterality, compared to 7.5% in the control group (p < or = 0.05). Body laterality was mixed in 25% of dyslexic children and in 2.5% in the control group (p < or = 0.05) and there was 72.5% spatial disorientation in the group of dyslexics, whereas only 15% (p < or = 0.05) was found in the control group. CONCLUSIONS: The NDDTS proved to be a useful tool for demonstrating that mixed auditory laterality and auditory predominance of the left ear are linked to dyslexia. The results of this test exceed those obtained for body laterality. Spatial orientation is indeed altered in children with dyslexia. The importance of this finding makes it necessary to study the central auditory processes in all cases in order to define better rehabilitation strategies in Spanish-speaking children.