Assuntos
Síndrome da Imunodeficiência Adquirida , Herpes Genital , Herpes Simples , Síndrome da Imunodeficiência Adquirida/complicações , Aciclovir/uso terapêutico , Antivirais/uso terapêutico , Foscarnet/uso terapêutico , Herpes Genital/tratamento farmacológico , Herpes Simples/tratamento farmacológico , Humanos , Imiquimode/uso terapêuticoRESUMO
Woolly hair nevus is a rare condition characterized by a structural anomaly of the hair, restricted to certain areas of the scalp. The hair becomes coiled and slightly hypopigmented. The term woolly hair refers to changes that affect all the scalp and has a hereditary character. We present a case of woolly hair nevus, that developed at the age of 2 years, associated with dental diastema and verrucous epidermal nevus.
Assuntos
Diastema/patologia , Doenças do Cabelo/patologia , Nevo Sebáceo de Jadassohn/patologia , Nevo/patologia , Neoplasias Cutâneas/patologia , Criança , Humanos , MasculinoRESUMO
The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. In this article, we present four different cases of CD30-positive T-cell lymphoma with cutaneous manifestations. We compare cases with definitive diagnosis of papulosis lymphomatoid type C, primary cutaneous anaplastic large T-cell lymphoma, systemic anaplastic large T-cell lymphoma with secondary skin involvement, and mycosis fungoides with large cell transformation, highlighting the importance of clinicopathological correlation to classify these cases.
Assuntos
Linfoma Anaplásico Cutâneo Primário de Células Grandes/patologia , Neoplasias Cutâneas/patologia , Adolescente , Idoso de 80 Anos ou mais , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-IdadeRESUMO
Abstract: The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. In this article, we present four different cases of CD30-positive T-cell lymphoma with cutaneous manifestations. We compare cases with definitive diagnosis of papulosis lymphomatoid type C, primary cutaneous anaplastic large T-cell lymphoma, systemic anaplastic large T-cell lymphoma with secondary skin involvement, and mycosis fungoides with large cell transformation, highlighting the importance of clinicopathological correlation to classify these cases.
Assuntos
Humanos , Masculino , Feminino , Adolescente , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Neoplasias Cutâneas/patologia , Linfoma Anaplásico Cutâneo Primário de Células Grandes/patologia , Imuno-HistoquímicaRESUMO
Abstract Woolly hair nevus is a rare condition characterized by a structural anomaly of the hair, restricted to certain areas of the scalp. The hair becomes coiled and slightly hypopigmented. The term woolly hair refers to changes that affect all the scalp and has a hereditary character. We present a case of woolly hair nevus, that developed at the age of 2 years, associated with dental diastema and verrucous epidermal nevus.
Assuntos
Humanos , Masculino , Criança , Neoplasias Cutâneas/patologia , Diastema/patologia , Nevo Sebáceo de Jadassohn/patologia , Doenças do Cabelo/patologia , Nevo/patologiaRESUMO
Abstract Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.
Assuntos
Humanos , Masculino , Criança , Pele/patologia , Dermatose Linear Bolhosa por IgA/patologia , Membrana Basal/patologia , Biópsia , Dermatopatias Vesiculobolhosas/patologia , Técnica Direta de Fluorescência para Anticorpo , Eritema/patologiaRESUMO
Abstract The use of tumor necrosis factor antagonists (anti-TNF) has become a usual practice to treat various inflammatory diseases. Although indicated for the treatment of psoriasis, anti-TNF may paradoxically trigger a psoriasiform condition. We present a case of a female patient who, during the use of infliximab for rheumatoid arthritis, developed psoriasis. In an attempt to switch anti-TNF class, we observed a cumulative worsening of the lesions requiring suspension of the immunobiological agent and the introduction of other drugs for clinical control. The therapeutic challenge of this paradoxical form of psoriasis is the focus of our discussion. The use of another anti-TNF in these patients is a matter of debate among experts.
Assuntos
Humanos , Feminino , Adulto , Artrite Reumatoide/tratamento farmacológico , Psoríase/induzido quimicamente , Psoríase/patologia , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Antirreumáticos/efeitos adversos , Infliximab/efeitos adversos , Pele/patologia , Adalimumab/efeitos adversosRESUMO
Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.
Assuntos
Dermatose Linear Bolhosa por IgA/patologia , Pele/patologia , Membrana Basal/patologia , Biópsia , Criança , Eritema/patologia , Técnica Direta de Fluorescência para Anticorpo , Humanos , Masculino , Dermatopatias Vesiculobolhosas/patologiaRESUMO
The use of tumor necrosis factor antagonists (anti-TNF) has become a usual practice to treat various inflammatory diseases. Although indicated for the treatment of psoriasis, anti-TNF may paradoxically trigger a psoriasiform condition. We present a case of a female patient who, during the use of infliximab for rheumatoid arthritis, developed psoriasis. In an attempt to switch anti-TNF class, we observed a cumulative worsening of the lesions requiring suspension of the immunobiological agent and the introduction of other drugs for clinical control. The therapeutic challenge of this paradoxical form of psoriasis is the focus of our discussion. The use of another anti-TNF in these patients is a matter of debate among experts.