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Purpose: This study aimed to associate nutritional and sarcopenia risk with clinical outcomes in elderly patients with COVID-19. Methods: This is a longitudinal retrospective cohort study. Hospitalized elderly individuals diagnosed with COVID-19 were included in the study. Nutritional risk was assessed using the Malnutrition Universal Screening Tool (MUST), and Sarcopenia risk was assessed using the SARC-F. Associations were assessed through multivariable logistic models. Results: In total, 127 patients (mean age: 71.25 ±8.06 years) were followed up until the clinical outcome. Sarcopenia risk was diagnosed in 63.8% of the sample, whereas nutritional risk was observed in 72%. Hospitalization in the intensive care unit (ICU) was required in 48.8% of the sample, 38.6% required mechanical ventilation, and 32.3% died. Elderly individuals with sarcopenia risk were more likely to be hospitalized in ICUs (OR: 5.62; 95%CI: 2.2-14.3), require mechanical ventilation (OR: 4.0; 95% CI: 1.5-10.2), and die (OR: 5.06; 95% CI: 1.7-14.2). The risk of malnutrition assessed through MUST was an important risk factor for death (OR = 30.15; 95% CI: 3.6-245.8; p<0.01). Conclusion: Sarcopenia risk was a risk factor for death, hospitalization in ICU, and mechanical ventilation, while nutritional risk was a risk factor for death (AU).

Objetivo: Este estudo teve como objetivo associar o risco nutricional e de sarcopenia com desfechos clínicos em pacientes idosos com COVID-19. Métodos: Trata-se de um estudo de coorte retrospectivo longitudinal. Idosos hospitalizados com diagnóstico de COVID-19 foram incluídos no estudo. O risco nutricional foi avaliado usando o Malnutrition Universal Screening Tool (MUST) e o risco de sarcopenia foi avaliado usando o SARC-F. As associações foram avaliadas por modelos logísticos multivariados. Resultados: No total, 127 pacientes (média de idade: 71,25 ±8,06 anos) foram acompanhados até o desfecho clínico. Risco de sarcopenia foi diagnosticado em 63,8% da amostra, enquanto risco nutricional foi observado em 72% deles. Além disso, 48,8% da amostra necessitou de internação em unidade de terapia intensiva (UTI), 38,6% necessitaram ventilação mecânica e 32,3% foram a óbito. Idosos com risco de sarcopenia tiveram maior chance de internação em UTI (OR: 5,62; IC 95%: 2,2-14,3), necessidade de ventilação mecânica (OR: 4,0; IC 95%: 1,5-10,2) e óbito (OR: 5,06; IC 95%: 1,7-14,2). O risco de desnutrição avaliado pelo MUST foi um importante fator de risco para óbito (OR = 30,15; IC 95%: 3,6-245,8; p<0,01). Conclusão: O risco de sarcopenia foi fator de risco para óbito, internação em UTI e ventilação mecânica, enquanto o risco nutricional foi fator de risco para óbito (AU).

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This study aimed to analyze the overweight (OW) prevalence trends from 2008 to 2018 among under-five-year-old children assisted by the conditional cash transfer program entitled Programa Bolsa Família (PBF). The panel was based on the Food and Nutritional Surveillance System (SISVAN) (n=30,574,118) nutritional status reports. Age- (infants and preschoolers) and region-specific joinpoint regression models were used to analyze OW's prevalence temporal changes. Besides, the coverage of SISVAN for PBF and national representativity were calculated according to census projection. In the decade analyzed, OW in infants decreased from 11.9% (11.8; 12.0 95%CI) to 8.5% (8.4; 8.6 95%CI) (-3.6%/year [-5.1; -2.0 95%CI]); for preschool children, the prevalence of OW increased by 3.1%/year (2.0; 4.2 95%CI) until 2015, followed by a decrease until 2018 (-6.4%/year [-10.1; -2.6 95%CI]). In both age groups, the North region had the lowest prevalence in all time-series, and the Northeast had the worst performance in managing childhood obesity. The SISVAN's coverage in the PBF was high, and the data representativity varied between 13.9% (South) and 42.2% (Northeast). Although the prevalence was higher than expected, after 2014, it was detected a linear reduction in OW in infants and a deceleration in the growth rate in preschoolers.

O objetivo deste estudo foi analisar a tendência temporal da prevalência de excesso de peso (EP) em crianças menores de cinco anos assistidas pelo Programa Bolsa Família (PBF) entre 2008 e 2018. O painel de dados foi baseado nos relatórios de estado nutricional do Sistema de Vigilância Alimentar e Nutricional (SISVAN) (n=30.574.118) e analisado por meio de modelos de regressão joinpoint específicos para idade (lactentes e pré-escolares) e macrorregião. Ainda, calculou-se a cobertura do SISVAN para o PBF e a representatividade nacional, segundo projeção censitária. Na década analisada, o EP em lactentes reduziu de 11,9% (11,8; 12,0 IC95%) para 8,5% (8,4; 8,6 IC95%) (-3,6%/ano [-5,1; -2,0 IC95%]); quanto aos pré-escolares, a prevalência EP aumentou em 3,1%/ano (2,0; 4,2 IC95%) até 2015, seguida por uma retração até 2018 (-6,4%/ano [-10,1; -2,6 IC95%]). Em ambos os grupos etários, a região Norte apresentou a menor prevalência em toda série histórica e a Nordeste o pior desempenho no controle do EP infantil. A cobertura do SISVAN no PBF foi elevada e a representatividade dos dados variou entre 13,9% (Sul) e 42,2% (Nordeste). Apesar da prevalência estar acima do esperado, após 2014, identificou-se redução linear no EP em lactentes e desaceleração na taxa de crescimento nos pré-escolares.

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Resumo O objetivo deste estudo foi analisar a tendência temporal da prevalência de excesso de peso (EP) em crianças menores de cinco anos assistidas pelo Programa Bolsa Família (PBF) entre 2008 e 2018. O painel de dados foi baseado nos relatórios de estado nutricional do Sistema de Vigilância Alimentar e Nutricional (SISVAN) (n=30.574.118) e analisado por meio de modelos de regressão joinpoint específicos para idade (lactentes e pré-escolares) e macrorregião. Ainda, calculou-se a cobertura do SISVAN para o PBF e a representatividade nacional, segundo projeção censitária. Na década analisada, o EP em lactentes reduziu de 11,9% (11,8; 12,0 IC95%) para 8,5% (8,4; 8,6 IC95%) (-3,6%/ano [-5,1; -2,0 IC95%]); quanto aos pré-escolares, a prevalência EP aumentou em 3,1%/ano (2,0; 4,2 IC95%) até 2015, seguida por uma retração até 2018 (-6,4%/ano [-10,1; -2,6 IC95%]). Em ambos os grupos etários, a região Norte apresentou a menor prevalência em toda série histórica e a Nordeste o pior desempenho no controle do EP infantil. A cobertura do SISVAN no PBF foi elevada e a representatividade dos dados variou entre 13,9% (Sul) e 42,2% (Nordeste). Apesar da prevalência estar acima do esperado, após 2014, identificou-se redução linear no EP em lactentes e desaceleração na taxa de crescimento nos pré-escolares.

Abstract This study aimed to analyze the overweight (OW) prevalence trends from 2008 to 2018 among under-five-year-old children assisted by the conditional cash transfer program entitled Programa Bolsa Família (PBF). The panel was based on the Food and Nutritional Surveillance System (SISVAN) (n=30,574,118) nutritional status reports. Age- (infants and preschoolers) and region-specific joinpoint regression models were used to analyze OW's prevalence temporal changes. Besides, the coverage of SISVAN for PBF and national representativity were calculated according to census projection. In the decade analyzed, OW in infants decreased from 11.9% (11.8; 12.0 95%CI) to 8.5% (8.4; 8.6 95%CI) (-3.6%/year [-5.1; -2.0 95%CI]); for preschool children, the prevalence of OW increased by 3.1%/year (2.0; 4.2 95%CI) until 2015, followed by a decrease until 2018 (-6.4%/year [-10.1; -2.6 95%CI]). In both age groups, the North region had the lowest prevalence in all time-series, and the Northeast had the worst performance in managing childhood obesity. The SISVAN's coverage in the PBF was high, and the data representativity varied between 13.9% (South) and 42.2% (Northeast). Although the prevalence was higher than expected, after 2014, it was detected a linear reduction in OW in infants and a deceleration in the growth rate in preschoolers.

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Reducing sedentary behaviour (SB) and increasing physical activity (PA) by sitting less and standing/walking more is advised to prevent chronic diseases. However, the mechanisms underlying this recommendation are not well established, especially in individuals with obesity living in low-income regions. The present study evaluated whether there are associations between PA indicators (PAI - standing time, walking time and the number of steps/d) and SB indicators (SBI - sitting/lying down time) with the hormonal profile and resting energy expenditure (REE) of adult women living in a low-income region. This is a cross-sectional study. We collected data on hormones (insulin resistance, leptin and thyroid axis), body composition (tetrapolar bioimpedance), REE (indirect calorimetry), and PAI and SBI (triaxial accelerometers, ActivPAL). Multivariable linear models adjusting for age and fat-free mass were performed. Fifty-eight women (mean age of 31 years and BMI of 33 kg/m2) were included. The mean sitting/lying down time and standing time were 16·08 and 5·52 h/d, respectively. Sitting/lying down time showed a direct association with free thyroxine (FT4) (ß = 0·56 ng/dl; 95 % CI = -1·10, -0·02). Standing time showed a direct association with FT4 (ß = 0·75 ng/dl; 95 % CI = 0·01; 1·48) and inverse association with free triiodothyronine (ß = -2·83 pg/ml 95 % CI = -5·56, -0·10). There were no associations between PAI and SBI with the REE, insulin resistance, leptin and thyroid-stimulating hormone. Thus, decreased SB is associated with thyroid hormones levels but not with REE, insulin resistance or leptin in women with obesity living in low-income regions.

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This ecological study aimed to analyze the trend of the nutritional status of pregnant adolescent beneficiaries of the Brazilian Bolsa Família conditional cash transfer program in the 2008-2018 period. We evaluated secondary data of pregnant adolescent beneficiaries of the Bolsa Família Program from January 2008 to December 2018, extracted from the public reports of the WEB Food and Nutrition Surveillance System. We accessed the monitoring reports on the consolidated public-access health conditionalities of the Bolsa Família Program, always considering the second validity. An annual variation of -1.2% (95%CI: [-1.6; -0.8] p<0.01) was observed in the prevalence of underweight in Brazil in the studied sample. The prevalence of overweight and obesity in the country had annual variations of 2.9% (95%CI: [2.0; 3.7] p<0.01) and 7.5% (95%CI: [5.7; 9.3] p<0.01), respectively. We conclude by saying, that, in the evaluated period, the prevalence of underweight among pregnant adolescent beneficiaries of the Bolsa Família Program showed a decreasing trend, while the prevalence of overweight and obesity increased throughout Brazil.

Trata-se de um estudo ecológico que objetivou analisar a tendência do estado nutricional de gestantes adolescentes beneficiárias do programa brasileiro de transferência condicionada de renda, Bolsa Família, no período 2008-2018. Foram avaliados dados secundários de gestantes adolescentes beneficiárias do Programa Bolsa Família no período de janeiro de 2008 a dezembro de 2018, extraídos dos relatórios públicos do Sistema de Vigilância Alimentar e Nutricional WEB. Foram consultados os relatórios de acompanhamento das condicionalidades de saúde consolidados de acesso público do Programa Bolsa Família, sempre considerando a 2ª vigência. Observou-se uma variação anual de -1,2% (IC95%: [-1,6; -0,8] p<0,01) na prevalência de baixo peso na amostra estudada. Com relação as prevalências de sobrepeso e obesidade no país, observou-se variações anuais de 2,9% (IC95%: [2,0; 3,7] p<0,01) e 7,5% (IC95%: [5,7; 9,3] p<0,01), respectivamente. Conclui-se que, no período avaliado, a prevalência de baixo peso entre as gestantes adolescentes beneficiárias do Programa Bolsa Família apresentou uma tendência decrescente, ao passo que as prevalências de sobrepeso e obesidade apresentam uma tendência crescente em todo o Brasil.

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Resumo Trata-se de um estudo ecológico que objetivou analisar a tendência do estado nutricional de gestantes adolescentes beneficiárias do programa brasileiro de transferência condicionada de renda, Bolsa Família, no período 2008-2018. Foram avaliados dados secundários de gestantes adolescentes beneficiárias do Programa Bolsa Família no período de janeiro de 2008 a dezembro de 2018, extraídos dos relatórios públicos do Sistema de Vigilância Alimentar e Nutricional WEB. Foram consultados os relatórios de acompanhamento das condicionalidades de saúde consolidados de acesso público do Programa Bolsa Família, sempre considerando a 2ª vigência. Observou-se uma variação anual de -1,2% (IC95%: [-1,6; -0,8] p<0,01) na prevalência de baixo peso na amostra estudada. Com relação as prevalências de sobrepeso e obesidade no país, observou-se variações anuais de 2,9% (IC95%: [2,0; 3,7] p<0,01) e 7,5% (IC95%: [5,7; 9,3] p<0,01), respectivamente. Conclui-se que, no período avaliado, a prevalência de baixo peso entre as gestantes adolescentes beneficiárias do Programa Bolsa Família apresentou uma tendência decrescente, ao passo que as prevalências de sobrepeso e obesidade apresentam uma tendência crescente em todo o Brasil.

Abstract This ecological study aimed to analyze the trend of the nutritional status of pregnant adolescent beneficiaries of the Brazilian Bolsa Família conditional cash transfer program in the 2008-2018 period. We evaluated secondary data of pregnant adolescent beneficiaries of the Bolsa Família Program from January 2008 to December 2018, extracted from the public reports of the WEB Food and Nutrition Surveillance System. We accessed the monitoring reports on the consolidated public-access health conditionalities of the Bolsa Família Program, always considering the second validity. An annual variation of -1.2% (95%CI: [-1.6; -0.8] p<0.01) was observed in the prevalence of underweight in Brazil in the studied sample. The prevalence of overweight and obesity in the country had annual variations of 2.9% (95%CI: [2.0; 3.7] p<0.01) and 7.5% (95%CI: [5.7; 9.3] p<0.01), respectively. We conclude by saying, that, in the evaluated period, the prevalence of underweight among pregnant adolescent beneficiaries of the Bolsa Família Program showed a decreasing trend, while the prevalence of overweight and obesity increased throughout Brazil.

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BACKGROUND & AIMS: Time-restricted feeding (TRF) studies have been summarized in previous systematic reviews, but these were not specific for individuals with excess weight and studies involving early time-restricted feeding (eTRF). This meta-analysis aimed to evaluate the effect of eTRF on the metabolic profile of adults with excess weight. METHODS: Data were extracted from MEDLINE, CENTRAL, LILACS, Web of Science, ClinicalTrials.gov, OpenGrey.eu, Greylit, and by manual search. Randomized controlled trials in which the participants were older than 18 years, with a body mass index greater than 25 kg/m2 and that were allocated in an intervention with eTRF were included. The studies should have assessed any of the following outcomes from the metabolic profile: resting metabolic rate, triacylglycerol, total cholesterol, HDL-cholesterol, and LDL-cholesterol, fasting blood glucose, insulin, HOMA-IR, C-reactive protein, Interleukin-6, cortisol, leptin, Ghrelin, Peptide YY and glucagon-like peptide, hemodynamic parameters, and appetite. The risk of bias was assessed using the Cochrane collaboration tool. Publication bias was examined with a funnel plot and Egger's test. GRADE was used to assess the overall quality of evidence. RESULTS: Ten articles from nine randomized clinical trials, with 264 individuals, were included in qualitative analysis and eight articles with 184 individuals were included in the meta-analysis. There were significant effects on the fasting blood glucose (WMD: -2.75; 95% CI [-4.59; -0.90] mg/dL; p < 0.01; I2 = 88.7%; 7 studies) and HOMA-IR. (WMD: -0.50; 95% CI [-0.82; -0.19]; p < 0.01; I2 = 50.8%; 4 studies). The other outcomes were not significant. Three studies showed a high risk of bias. Seven outcomes were classified as very low quality and one as low quality. There was evidence of publication bias for fasting blood glucose. CONCLUSIONS: Although the eTRF regimen seems to have a beneficial effect on the fasting blood glucose and HOMA-IR of individuals with excess weight, the results of this meta-analysis should be analyzed with caution due to the low-quality evidence.

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ABSTRACT Objectives Indirect calorimetry is established as a gold standard to determine the resting metabolic rate (RMR), however, its clinical use is limited, especially in low-income settings. Thus, the use of predictive equations appear as an alternative to estimate the RMR, but its precision is debatable, especially in obese individuals and in populations without specifically developed equations. To evaluate the agreement between the RMR estimated by equations and by indirect calorimetry in low-income obese women. Subjects and methods A cross-sectional study with adult and obese women, which estimated the RMR by indirect calorimetry and compared with 13 predictive equations using the concordance correlation coefficient, root mean square error (RMSE) and Bland-Altman methods. The maximum allowed differences were predefined as 10%. Results No equation presented its confidence intervals for the Bland-Altman limits of agreement inside the predefined acceptable range. The Harris-Benedict equation achieved better agreement (bias of 2.9% and RMSE of 274.3kcal) whereas the Henry-Rees equation achieved better precision (42.3% of the sample within the 10% maximum allowed difference). Conclusion None of the studied equations satisfactorily estimated the RMR estimated by indirect calorimetry. In the absence of specific equations for this population, the use of the Harris-Benedict and Henry-Rees equations could be considered.

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Objectives Indirect calorimetry is established as a gold standard to determine the resting metabolic rate (RMR), however, its clinical use is limited, especially in low-income settings. Thus, the use of predictive equations appear as an alternative to estimate the RMR, but its precision is debatable, especially in obese individuals and in populations without specifically developed equations. To evaluate the agreement between the RMR estimated by equations and by indirect calorimetry in low-income obese women. Subjects and methods A cross-sectional study with adult and obese women, which estimated the RMR by indirect calorimetry and compared with 13 predictive equations using the concordance correlation coefficient, root mean square error (RMSE) and Bland-Altman methods. The maximum allowed differences were predefined as 10%. Results No equation presented its confidence intervals for the Bland-Altman limits of agreement inside the predefined acceptable range. The Harris-Benedict equation achieved better agreement (bias of 2.9% and RMSE of 274.3kcal) whereas the Henry-Rees equation achieved better precision (42.3% of the sample within the 10% maximum allowed difference). Conclusion None of the studied equations satisfactorily estimated the RMR estimated by indirect calorimetry. In the absence of specific equations for this population, the use of the Harris-Benedict and Henry-Rees equations could be considered.

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