RESUMO
[This corrects the article DOI: 10.3762/bjoc.13.167.].
RESUMO
The use of mechanochemistry to carry out enantioselective reactions has been explored in the last ten years with excellent results. Several chiral organocatalysts and even enzymes have proved to be resistant to milling conditions, which allows for rather efficient enantioselective transformations under ball-milling conditions. The present article reports the first example of a liquid-assisted grinding (LAG) mechanochemical enzymatic resolution of racemic ß3-amino esters employing Candida antarctica lipase B (CALB) to afford highly valuable enantioenriched N-benzylated-ß3-amino acids in good yields. Furthermore the present protocol is readily scalable.
RESUMO
Los resultados observados en esta serie de 18 casos evaluados en 3 años demuestran: que la atención del traumatismo abdominal en un Servicio de Urgencia, que cuenta con la adecuada infraestructura de recursos humanos y tecnológicos, redunda en un diagnóstico y terapéutica precoces. Una menor incidencia de complicaciones. Rehabilitación precoz. Alto índice de sobrevida