RESUMO

Two hundred fifteen compounds isolated from plants of Northeastern Brazil flora have been assayed against epimastigote forms of Trypanosoma cruzi, using the tetrazolium salt MTT as an alternative method. Eight compounds belonging to four different species: Harpalyce brasiliana (Fabaceae), Acnistus arborescens and Physalis angulata (Solanaceae), and Cordia globosa (Boraginaceae) showed significant activity. Among them, a novel and a known pterocarpan, a chalcone, four withasteroids, and a meroterpene benzoquinone were the represented chemical classes.

Assuntos

Plantas Medicinais/química , Pterocarpanos/isolamento & purificação , Pterocarpanos/farmacologia , Tripanossomicidas/isolamento & purificação , Trypanosoma cruzi/efeitos dos fármacos , Animais , Células Sanguíneas/parasitologia , Brasil , Células Cultivadas , Chalcona , Humanos , Concentração Inibidora 50 , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Pterocarpanos/química , Relação Estrutura-Atividade , Tripanossomicidas/química , Tripanossomicidas/farmacologia