RESUMO
BACKGROUND: Cysts are very common in the routine of dermatopathology but follicular germinative (trichoblastic) differentiation in cysts is seen rarely. The presence of follicular germinative differentiation in a cyst alerts to consider the possibility of a basal cell carcinoma (BCC) arising in a cyst. METHODS: Five cystic lesions with zones of follicular germinative differentiation were collected. Hematoxylin and eosin sections were reassessed for architecture, types of follicular differentiation and stromal characteristics; immunohistochemical studies with Ber-EP4 were analyzed. Articles about follicular germinative differentiation in cystic lesions were reviewed. RESULTS: Cystic lesions with follicular germinative differentiation have been described in the literature under various names including trichoblastic infundibular cyst, cystic trichoblastoma, cystic panfolliculoma (CPF), dermoid cyst with basaloid proliferations, folliculosebaceous cystic hamartoma and BCC occurring in infundibular cysts. The lesions presented by us could be classified as three cystic trichoblastomas, one CPF and one cystic hamartoma with follicular germinative differentiation. CONCLUSIONS: Histopathologically, cystic trichoblastomas can be separated from CPFs. Some lesions defy classification and may be regarded as cystic follicular hamartomas. The presence of follicular papillae and bulb-like structures, advanced follicular differentiation like that of inner and outer root sheath exclude the differential diagnosis of BCC arising in a cyst.
Assuntos
Diferenciação Celular , Cisto Dermoide , Cisto Epidérmico , Hamartoma , Neoplasias Cutâneas , Adulto , Cisto Dermoide/classificação , Cisto Dermoide/metabolismo , Cisto Dermoide/patologia , Cisto Epidérmico/classificação , Cisto Epidérmico/metabolismo , Cisto Epidérmico/patologia , Hamartoma/classificação , Hamartoma/metabolismo , Hamartoma/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/classificação , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologiaRESUMO
Connective tissue nevi may be multiple or solitary, sporadic or familial. Eruptive collagenoma is a variant of the acquired collagenomas characterized by multiple sclerotic papules with an acute onset. A 13-year-old girl reported that in the past year, small asymptomatic lesions began to appear in her skin, 30 lesions were seen in the trunk, 5 in the cervical region and 1 in the face. Light microscopy with hematoxylin and eosin staining showed sparse collagen fibers, with Weigert staining diminished elastic tissue was observed. Scanning electron microscopy of the dermis showed individualized collagen fibers forming waved compact masses and not bundles. Transmission electron microscopy also showed sparse and loose collagen fibers with different diameters in cross sections.
Assuntos
Colágeno , Hamartoma/ultraestrutura , Dermatopatias/patologia , Adolescente , Feminino , Humanos , Microscopia Eletrônica de Varredura , Microscopia Eletrônica de TransmissãoRESUMO
Cutis laxa is a rare condition characterized by diminished elastic tissue. We report the histological changes from a 22-year-old male patient, who presented since 4 years hanging and inelastic facial skin, giving him an older appearance. The palpebral, preauricular and submandibular skin obtained after a facelift were examined. Conventional light microscopy with hematoxylin-eosin staining showed perivascular lymphocytic infiltrates and crossed-over collagen fibers. With Weigert staining, a lessening of elastic fibers with fragmentation, shortening and clumping was seen. The oxytalanic fibers in the papillary dermis were also affected, ranging from absence or reduction to flattening with clumping of the fibers, giving an irregular contour to the basal membrane zone. These findings were more intense in the palpebral skin. Transmission electronic microscopy showed reduction of the elastic fibers, a granular degeneration of the elastic tissue was found and collagen fibers were normal. Similar to light microscopy, at the ultrastructural level, the basal membrane has an irregular contour.
Assuntos
Cútis Laxa/patologia , Tecido Elástico/ultraestrutura , Adulto , Cútis Laxa/cirurgia , Tecido Elástico/cirurgia , Cabeça , Humanos , Masculino , Microscopia Eletrônica de Transmissão , Coloração e Rotulagem , Cirurgia Plástica , Resultado do TratamentoAssuntos
Artralgia/complicações , Cútis Laxa/etiologia , Tecido Elástico/ultraestrutura , Face , Pele/patologia , Adulto , Articulação do Tornozelo , Cútis Laxa/patologia , Cútis Laxa/cirurgia , Diagnóstico Diferencial , Humanos , Masculino , Microscopia Eletrônica de Transmissão , Procedimentos de Cirurgia Plástica/métodosRESUMO
As tubercúlides são reações cutâneas imunológicas à presença de tuberculose, que com freqüência se encontra oculta no organismo. Antigamente um grande número de lesões cutâneas era interpretado como tubercúlide. Atualmente, porém, apenas três entidades são consideradas verdadeiras tubercúlides: tubercúlide papulonecrótica, eritema indurado e o líquen scrofulosorum. Pacientes com líquen scrofulosorum apresentam forte reação ao teste de Mantoux e excelente resposta aos tuberculostáticos.
Tuberculids are cutaneous immunologic reactions to the presence of tuberculosis, which is often occult elsewhere in the body. A wide range of skin disorders has been interpreted as tuberculids in the past. Currently, however, only three entities are regarded as true tuberculids: papulonecrotic tuberculid, erythema induratum and lichen scrofulosorum. Patients with lichen scrofulosorum have a strongly positive tuberculin reaction and an excellent response to treatment with antituberculous drugs.
RESUMO
Foram atendidos no Departamento de Neurocicurgia da Universidade de Berlim, nos anos de 1985 e de 1986, dois casos de cisto aracnóide do terceiro ventrículo, ambos submetidos com sucesso a tratamento cirúrgico. Säo eles registrados neste artigo. Os cistos aracnóides do sistema ventricular e das cisternas säo raros. Até o momento tinham sido registrados 46 casos na literatura. A tomografia axial computadorizada e a tomografia de ressonância magnética tornaram fácil o diagnóstico desta entidade, como se verifica nos casos registrados