RESUMO

We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection.

Assuntos

Anticorpos Antivirais/sangue , Infecções por Citomegalovirus/epidemiologia , Infecções por Citomegalovirus/imunologia , Citomegalovirus/imunologia , Complicações Infecciosas na Gravidez/virologia , Adulto , Pré-Escolar , Colômbia/epidemiologia , Citomegalovirus/genética , Infecções por Citomegalovirus/congênito , Infecções por Citomegalovirus/urina , DNA Viral/urina , Feminino , Idade Gestacional , Humanos , Imunoglobulina G/sangue , Lactente , Mães , Gravidez , Complicações Infecciosas na Gravidez/epidemiologia , Complicações Infecciosas na Gravidez/imunologia , Saliva/virologia , Estudos Soroepidemiológicos