Assuntos
Hicantone/uso terapêutico , Esquistossomose/tratamento farmacológico , Tioxantenos/uso terapêutico , Adolescente , Animais , Criança , Ensaios Clínicos como Assunto , Enzimas/sangue , Feminino , Humanos , Hicantone/efeitos adversos , Masculino , Contagem de Ovos de Parasitas , Schistosoma mansoni , Índias OcidentaisRESUMO
A mollusciciding campaign was begun in Cul-de-Sac Valley, St Lucia, at the end of 1970, following several years of epidemiological studies in which transmission of Schistosoma mansoni was found to be high in settlements on the valley floor but low in hillside settlements. Postcontrol (1971-73) findings in children, when compared with precontrol data and with data from an adjacent valley having a similar transmission pattern, show significant reductions in prevalence, incidence, and intensity of infection.
Assuntos
Moluscocidas , Controle de Pragas , Esquistossomose/prevenção & controle , Adolescente , Biomphalaria , Criança , Pré-Escolar , Humanos , Lactente , Schistosoma mansoni , Esquistossomose/transmissão , Índias OcidentaisRESUMO
As an experimental control measure to reduce the transmission of S. mansoni, an individual household water supply was provided in 400 houses in 5 rural settlements of the Riche Fond Valley, St Lucia. This population of about 2 000 had previously been dependent for water on infective streams and rivers. Six other settlements in the valley, all provided with limited piped water from public standpipes, served as the comparison area. After 2 years the incidence, prevalence, and intensity of infection with S. mansoni were significantly lower in the household water supply area, whereas all these indices of infection had increased in the comparison area. An adequate, reliable, and convenient supply of water can reduce the transmission of S. mansoni and should be considered as a control measure in other endemic areas.
Assuntos
Schistosoma mansoni , Esquistossomose/prevenção & controle , Abastecimento de Água , Adolescente , Animais , Criança , Pré-Escolar , Feminino , Habitação , Humanos , Lactente , Masculino , Esquistossomose/transmissão , Índias OcidentaisRESUMO
Of 433 schistosomiasis mansoni patients in St. Lucia who were treated with hycanthone (3 mg/kg of body weight), 190 were seen 2 years after treatment and 143 of these had attended all follow-up examinations at 6 weeks, 6 months, 1 year and 2 years. Viable eggs were not detected in 86% at 1 year nor in 76% at 2 years. The reinfection rate, as judged by a significant increase in egg excretion, was 15% and was related to the geographic area to which the patient returned. Extremely high total reduction in egg excretion (98%) was achieved through 1 year, and even with reinfections this fell only to 87% at 2 years. Liver and spleen enlargement was related to intensity of infection and responded to treatment in 92% and 83% of instances, respectively. Among patients with hepatosplenomegaly, those 15 years or older showed less clinical response than younger patients but were too few for statistical comparison.