RESUMO
A 30-year-old woman developed a slowly progressive reddish-violet multinodular rubbery lesion, measuring 20 x 10 cm in diameter, on the upper outer quadrant of her right breast four years after the surgical excision of a dermatofibrosarcoma protuberans (DFSP) in the same area. The diagnosis of DFSP was confirmed histologically and by positive immunomarkers at immunohistochemistry. A complete excision was performed and after a 2-year follow-up no recurrence was observed. It should be emphasized that DFSP of the breast is a rare occurrence.
Assuntos
Dermatofibrossarcoma/patologia , Neoplasias Cutâneas/patologia , Adulto , Feminino , HumanosRESUMO
The family Polyomaviridae is composed of small, non-enveloped, double-stranded DNA viruses widely used to study cell transformation in vitro and tumor induction in vivo. The development of pilomatricomas in mice experimentally infected with polyomavirus led us to detect the viral major capsid protein VP-1 in human pilomatricomas. This tumor, even uncommon, is one of the most frequent benign hair follicle tumors in humans and is composed of proliferating matrix cells that undergo keratinization, and form cystic neoplasms. The detection of VP-1 was performed using the peroxidase-antiperoxidase technique in paraffin-embedded slides with a specific primary serum. Adjacent slides treated with normal rabbit serum as a primary were employed as internal control. Positive and negative controls were also employed as well as slides of lesions caused by human papillomavirus to rule out any unspecific cross-reactivity. In 4 out of 10 cases polyomavirus VP-1 was clearly detected in nuclei of human pilomatricomas proliferating cells, in a patchy pattern of distribution. The controls confirmed the specificity of the immunocytochemical procedure. These results could indicate either an eventual infection of the virus in already developed tumors or alternatively, a direct involvement of polyomavirus in the pathogenesis of some pilomatricomas. The recent discovery of a new human polyomavirus associated with Merkel cell carcinomas has been a strong contribution to better understand the pathogenesis of some human uncommon skin cancers. Hopefully the results reported in this work will encourage further research on the role of polyomavirus in other human skin neoplasms.
Assuntos
Proteínas do Capsídeo/análise , Doenças do Cabelo/virologia , Pilomatrixoma/virologia , Infecções por Polyomavirus/patologia , Neoplasias Cutâneas/virologia , Infecções Tumorais por Vírus/virologia , Animais , Antígenos Virais/análise , Doenças do Cabelo/patologia , Humanos , Técnicas Imunoenzimáticas , Camundongos , Inclusão em Parafina , Pilomatrixoma/patologia , Neoplasias Cutâneas/patologia , Infecções Tumorais por Vírus/patologiaRESUMO
Presentamos a una paciente de 30 años de edad, que desarrolla en forma lenta y progresiva una tumoración rojo violácea multinodular de consistencia duroelástica de 20cm por 10cm en el cuadrante superoexterno de su mama derecha, a los cuatro años de habérsele extirpado un dermatofiborsarcoma protuberans (DFSP) en dicha localización. El estudio histopatológico y la imnunomarcación confirmaron la recidiva. A los dos años de la nueva intervención quirúrgica no existen evidencias de lesión neoplásica. Debe considerarse infrecuente la localización mamaria de esta patología.
A 30-year-old woman developed a slowly progressive reddish-violet multinodular rubbery lesion, measuring 20 x 10 cm in diameter, on the upper outer quadrant of her right breast four years after the surgical excision of a dermatofibrosarcoma protuberans (DFSP) in the same area. The diagnosis of DFSP was confirmed histologically and by positive immunomarkers at immunohistochemistry. A complete excision was performed and after a 2-year follow-up no recurrence was observed. It should be emphasized that DFSP of the breast is a rare occurrence.
Assuntos
Adulto , Feminino , Humanos , Dermatofibrossarcoma/patologia , Neoplasias Cutâneas/patologiaRESUMO
True histiocytic malignancies (THM) are controversial disorders that are being re-evaluated with modern cellular and molecular biology techniques. True histiocytic lymphoma (THL) is a low-incidence, poor-prognosis THM. It mainly affects the skin, gastrointestinal tract, and bone tissues. Occasionally, skin lesions are the presenting clinical features. A patient with initially cutaneous THL is described. This and other reported cases confirm that THM are a nosologic entity by themselves.
Assuntos
Transtornos Histiocíticos Malignos/diagnóstico , Linfoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Diagnóstico Diferencial , Evolução Fatal , Transtornos Histiocíticos Malignos/tratamento farmacológico , Transtornos Histiocíticos Malignos/patologia , Humanos , Linfoma/tratamento farmacológico , Linfoma/patologia , Masculino , Necrose , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/patologiaAssuntos
Síndrome de Behçet/complicações , Síndrome de Behçet/tratamento farmacológico , Criptococose/complicações , Glucocorticoides/uso terapêutico , Úlcera da Perna/etiologia , Prednisona/uso terapêutico , Adulto , Anfotericina B/uso terapêutico , Antifúngicos/uso terapêutico , Criptococose/diagnóstico , Criptococose/tratamento farmacológico , Cryptococcus neoformans , Humanos , MasculinoRESUMO
A pitiríase rósea purpúrica constitui doença rara e 10 casos foram publicados na Europa e EUA. O quadro clínico cutâneo é a forma hemorrágica ou purpúrica com variável descamação marginal. Relata-se o caso de um homem de 25 anos de idade com lesões na região escapular. A revisão da literatura enfatiza o diagnóstico diferencial das lesões purpúricas. Segundo Lilacs e Medline, não foram relatados casos na literatura latino-americana