RESUMO
A new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy. The prepared compounds were tested for anti-inflammatory and antimicrobial activities. The anti-inflammatory activities were determined in the rat paw oedema induced by carrageenin. Compounds 6a, c, f and g (i.v.) significantly inhibited the rat paw oedema induced by carrageenin depending upon the dose employed. The compounds were also evaluated for their in vitro antimicrobial activity. Some compounds were found to have significant activity against Gram positive and Gram negative microorganisms.
Assuntos
Anti-Infecciosos/síntese química , Anti-Inflamatórios não Esteroides/síntese química , Oxidiazóis/química , Animais , Antibacterianos , Bactérias/efeitos dos fármacos , Carragenina , Edema/induzido quimicamente , Edema/prevenção & controle , Fungos/efeitos dos fármacos , Masculino , Testes de Sensibilidade Microbiana , Oxidiazóis/farmacologia , Ratos , Ratos WistarRESUMO
The synthesis of six 2-methyl-3-arylidenoaminocyclohexeno [b] thieno [2,3-d]-3,4-dihydropyrimidin-4-ones is described. The biological activity of these new compounds was screened against several Gram-positive and Gram-negative bacteria. The activity of our compounds is 5 to 320 fold less active than ciprofloxacin.