RESUMO
OBJECTIVE: To implement an HIV prevention intervention among female commercial sex workers (CSW), and to monitor key outcomes using routinely collected clinical and laboratory data. DESIGN: Cross-sectional and longitudinal analysis of data from an open-enrollment cohort. SETTING: One public sexually transmitted disease (STD) clinic and about 25 brothels in La Paz, Bolivia. PARTICIPANTS: A total of 508 female CSW who work at brothels and attend a public STD clinic. INTERVENTION: Improved STD clinical care, supported by periodic laboratory testing, and behavioral interventions performed by a local non-governmental organization. MAIN OUTCOME MEASURES: Prevalence of gonorrhea, syphilis (reactive plasma reagin titer > or = 1 : 16), genital ulcer disease, chlamydial infection, and trichomoniasis; self-reported condom use in the previous month; and HIV seroprevalence. RESULTS: From 1992 through 1995, prevalence of gonorrhea among CSW declined from 25.8 to 9.9% (P < 0.001), syphilis from 14.9 to 8.7% (P = 0.02), and genital ulcer disease from 5.7 to 1.3% (P = 0.006); trends in prevalence of chlamydial infection and trichomoniasis were not significant. Self-reported condom use during vaginal sex in the past month increased from 36.3 to 72.5% (P < 0.001). In a multivariate analysis, condom use was inversely associated with gonorrhea [odds ratio (OR), 0.63; 95% confidence interval (Cl), 0.41-0.97], syphilis (OR, 0.39; 95% Cl, 0.23-0.64), and trichomoniasis (OR, 0.44; 95% Cl, 0.32-0.71). In 1995, HIV seroprevalence among CSW was 0.1%. CONCLUSION: Effective prevention interventions for female CSW can be implemented through public services and non-governmental organizations while HIV rates are still low, and key outcomes can be monitored using data obtained from periodic screening examinations.
Assuntos
Infecções por HIV/epidemiologia , Infecções por HIV/prevenção & controle , Trabalho Sexual , Infecções Sexualmente Transmissíveis/epidemiologia , Infecções Sexualmente Transmissíveis/prevenção & controle , Adulto , Bolívia/epidemiologia , Preservativos , Feminino , Humanos , Análise Multivariada , Prevalência , Desenvolvimento de Programas , Fatores de Risco , Comportamento Sexual , Saúde da MulherRESUMO
OBJECTIVE: Anaerobic bacteremia rarely occurs in children. Therefore we assessed the usefulness of routinely obtaining anaerobic blood cultures in our pediatric patients. STUDY DESIGN: Records of 9360 paired aerobic anaerobic blood culture bottles (Bactec NR660 System) containing blood specimens from pediatric inpatients and outpatients at Duke University Medical Center, Durham, N.C., were reviewed retrospectively. Yield and speed of detection were calculated for each bottle and compared for statistical significance by the McNemar test. RESULTS: A total of 723 clinically important microorganisms were isolated; only 15 (2.1%) were strict anaerobes. Significantly more microorganisms (p < 0.001), especially staphylococci, nonfermenting gram-negative rods, enteric gram-negative rods, and yeasts, were detected by use of the aerobic bottle. The anaerobic bottle was important in identifying an anaerobic microorganism as the cause of sepsis in only five patients, all of whom were at increased risk of having anaerobic infection. CONCLUSIONS: Anaerobic blood cultures are rarely helpful in the majority of pediatric patients and usually show positive results only in clinical settings associated with anaerobic infection. Microorganisms that prefer an aerobic environment, such as Pseudomonas aeruginosa and yeasts, are now far more common than anaerobes in children; aerobic culturing of the entire volume of blood collected might increase the yield from pediatric blood cultures.
Assuntos
Bacteriemia/microbiologia , Bactérias Anaeróbias/isolamento & purificação , Adolescente , Bacteriemia/diagnóstico , Bacteriemia/epidemiologia , Bactérias Aeróbias/isolamento & purificação , Técnicas Bacteriológicas , Criança , Pré-Escolar , Meios de Cultura , Testes Diagnósticos de Rotina/estatística & dados numéricos , Humanos , Lactente , Prevalência , Estudos RetrospectivosRESUMO
To explore sexually transmitted diseases and sexual behavior as risk factors for cervical cancer, we analyzed data from a population-based case-control study of breast and cervical cancer in Costa Rica. Data from 415 cases of cervical carcinoma in situ, 149 cases of invasive cervical cancer, and 764 controls were included in the analysis. Multivariate analysis showed that lifetime number of sex partners, first intercourse before age 15 years, number of livebirths, herpes simplex virus type 2 seropositivity, and serologic evidence of previous chlamydial infection were predictors of carcinoma in situ. Serologic evidence of previous syphilis was not associated with carcinoma in situ. Predictors for invasive cervical cancer included lifetime number of sex partners, first intercourse before age 15 years, number of livebirths, serologic evidence of previous syphilis, herpes simplex type 2 infection, and chlamydial infection. Cigarette smoking, socioeconomic status, self-reported history of sexually transmitted diseases, and douching were not associated with either carcinoma in situ or invasive cervical cancer.