RESUMO

OBJECTIVE: To test the hypothesis that 5,10-methylenetetrahydroreductase (MTHFR) polymorphisms can partially explain the individual variation in developing attention-deficit/hyperactivity disorder (ADHD) after acute lymphoblastic leukemia (ALL) therapy. STUDY DESIGN: Parents of 48 survivors of childhood ALL completed a clinical diagnostic process to identify subtypes of ADHD. Genotyping was performed with peripheral blood DNA for MTHFR (C677T and A1298C) polymorphisms. RESULTS: Eleven of the 48 patients (22.9%) had scores consistent with the inattentive symptoms of ADHD. Patients with genotypes related to lower folate levels (11 out of 39; 39.2%) were more likely to have ADHD. The A1298C genotype appeared to be the predominant linkage to the inattentive symptoms, leading to a 7.4-fold increase in diagnosis, compared with a 1.3-fold increase for the C677T genotype. Age at diagnosis and sex were not associated with inattentiveness. CONCLUSIONS: Preliminary data imply a strong relationship between MTHFR polymorphisms and the inattentive symptoms of ADHD in survivors of childhood ALL.

Assuntos

Transtorno do Deficit de Atenção com Hiperatividade/genética , Metilenotetra-Hidrofolato Desidrogenase (NAD+)/genética , Polimorfismo Genético , Leucemia-Linfoma Linfoblástico de Células Precursoras , Adulto , Antimetabólitos Antineoplásicos/administração & dosagem , Antimetabólitos Antineoplásicos/efeitos adversos , Transtorno do Deficit de Atenção com Hiperatividade/enzimologia , Criança , Feminino , Antagonistas do Ácido Fólico/administração & dosagem , Antagonistas do Ácido Fólico/efeitos adversos , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Metotrexato/administração & dosagem , Metotrexato/efeitos adversos , Metilenotetra-Hidrofolato Desidrogenase (NAD+)/efeitos dos fármacos , Pais , Polimorfismo Genético/efeitos dos fármacos , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Inquéritos e Questionários , Sobreviventes