RESUMO

Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (-)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.

Assuntos

Consumo de Bebidas Alcoólicas/efeitos adversos , Benzopirenos/metabolismo , Dano ao DNA , Poluentes Ambientais/metabolismo , Boca/metabolismo , Consumo de Bebidas Alcoólicas/imunologia , Alcoolismo , Animais , Carcinogênese , Camundongos , Boca/imunologia , Neoplasias Bucais