RESUMO

Molecular genetic confirmatory testing with polymerase chain reaction amplification is integral to neonatal hemoglobinopathy screening programs. In this study, we demonstrate applicability of polymerase chain reaction-based testing for the common deletions in blacks responsible for hereditary persistence of fetal hemoglobin. This approach will provide rapid diagnostic clarification in newborn screening follow-up.

Assuntos

Anemia Falciforme/diagnóstico , Hemoglobina Fetal/genética , Deleção de Genes , Globinas/genética , Triagem Neonatal , Alelos , Anemia Falciforme/genética , Feminino , Genótipo , Hemoglobina Falciforme/genética , Heterozigoto , Humanos , Lactente , Recém-Nascido , Reação em Cadeia da Polimerase , Gravidez