RESUMO
We investigated the relationship between a VEGF genetic polymorphism and B cell chronic lymphocytic leukemia (B-CLL). A total of 102 patients with B-CLL and 124 healthy subjects were included in this study. All individuals were typed for the rs10434 in the vascular endothelial growth factor (VEGF) gene using the TaqMan technique. We found that the A allele and the AA genotype of rs10434 were more frequent in B-CLL patients than in control subjects (0.54 vs 0.34; 27 vs 13%; respectively). VEGF alleles and genotypes segregated similarly in patients at different disease stages according to Rai classification. These results suggest a possible association between the VEGF polymorphism and high-risk B-CLL.
Assuntos
Regiões 3' não Traduzidas/genética , Povo Asiático/genética , Leucemia Linfocítica Crônica de Células B/genética , Polimorfismo de Nucleotídeo Único , Fator A de Crescimento do Endotélio Vascular/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Alelos , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Grain shape and weight are the most important components of rice yield and are controlled by quantitative trait loci (QTLs). In this study, a double-haploid population, derived from the cross of japonica CJ06 and indica TN1, was used to analyze QTLs for grain shape and weight under two conditions: normal growth with unbroken husk and removing partial husk after flowering. Correlation analysis revealed that these traits, except grain weight, had a connection between the two conditions. Twenty-nine QTLs for grain shape and weight were detected on chromosomes 1 to 3; 6; 8 to 10; and 12, with the likelihood of odds value ranging from 2.38 to 5.36, including 10 different intervals. Some intervals were specifically detected after removing partial husk. The results contribute to the understanding of the genetic basis of grain filling and growth regulation, and provide us some assistance for improving grain plumpness in rice breeding.