RESUMO
The aim of this study was to evaluate the efficacy of the Portuguese version of the Medication Adherence Training Instrument (MATI) for improving adherence to antiretroviral therapy (ART) in southern Brazil. Two different follow-up modalities were compared in this 225 days randomized controlled study: one based on the MATI protocol and a conventional (non-MATI) clinical follow-up. There were no differences between the groups with the exception of socioeconomic class (P < 0.005). The mean length of continuance in treatment was 111.4 (SD = 13.9) and 137.6 (SD = 17.3) days in the MATI and non-MATI groups, respectively. A Mantel-Cox log-rank test revealed no significant difference between the two interventions (P = 0.34). Despite the sample size limitation, the results from this study indicate that the Portuguese version of the MATI was not more efficacious than the regular follow-up intervention for improving adherence of outpatients to ART.
Assuntos
Antirretrovirais/uso terapêutico , Infecções por HIV/tratamento farmacológico , Promoção da Saúde/métodos , Entrevistas como Assunto/métodos , Adesão à Medicação , Educação de Pacientes como Assunto/métodos , Adulto , Brasil , Protocolos Clínicos , Humanos , Estimativa de Kaplan-Meier , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores SocioeconômicosRESUMO
Alcohol abuse is one of the most serious problems in public health and the Wernicke-Korsakoff syndrome is one of the gravest consequences of alcoholism. The pathology is often undiagnosed in its less evident presentations, therefore an accurate diagnostic approach is a critical step in treatment planning. Treatment is based on restoration of thiamine, although this is insufficient to prevent the psychological decline of a great number of patients. The cognitive impact of the pathology is derived from the interaction of alcoholic neurotoxicity, thiamine deficiency and personal susceptibility. In this article, the literature concerning Wernicke-Korsakoff syndrome is reviewed.
Assuntos
Transtorno Amnésico Alcoólico/fisiopatologia , Doenças Metabólicas/fisiopatologia , Encefalopatia de Wernicke/fisiopatologia , Transtorno Amnésico Alcoólico/etiologia , Transtorno Amnésico Alcoólico/história , Transtorno Amnésico Alcoólico/patologia , Transtorno Amnésico Alcoólico/terapia , Alcoolismo/complicações , História do Século XIX , Humanos , Doenças Metabólicas/etiologia , Doenças Metabólicas/história , Doenças Metabólicas/patologia , Doenças Metabólicas/terapia , Prognóstico , Síndrome , Tiamina/uso terapêutico , Deficiência de Tiamina/complicações , Encefalopatia de Wernicke/etiologia , Encefalopatia de Wernicke/história , Encefalopatia de Wernicke/patologia , Encefalopatia de Wernicke/terapiaRESUMO
Alcohol abuse is one of most serious problems in public health and the Wernicke-Korsakoff syndrome one of the gravest consequences of alcoholism. The pathology is often undiagnosed in its less evident presentations, therefore an accurate diagnostic approach is a critical step in planning treatment. Besides new pharmacological proposals, treatment is based on the restoration of thiamine, although this is insufficient to prevent the psychological decline of a great number of patients. The cognitive impact of the pathology is derived from the interaction of alcoholic neurotoxicity, thiamine deficiency and personal susceptibility. In this article the history, epidemiology, clinical and neuropathological features of the Wernicke-Korsakoff syndrome, as well as some aspects of its treatment and prognosis, are described.