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Exp Clin Endocrinol Diabetes ; 125(5): 335-341, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28561194

RESUMO

The aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged≥18 and ≤30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile105Val gene polymorphism of the study participants. Also, biochemical analysis and hormone assays were carried out. A positive association between GSTP1 polymorphism and obesity was observed on subjects carrying at least one G allele (AG and GG). GG genotype was found only in the obese group. The G allele carriers presented 2.4 times higher chance of obesity when compared to those with the AA genotype. These results were independent of sex and age. We suggest that despite a study in population regional (south of Brazil), the GSTP1 gene polymorphism may play a significant role in the increase of susceptibility of obesity and contribute to identify the cardiovascular risk in young adults.


Assuntos
Alelos , Predisposição Genética para Doença , Glutationa S-Transferase pi/genética , Mutação de Sentido Incorreto , Obesidade/genética , Polimorfismo de Fragmento de Restrição , Adulto , Substituição de Aminoácidos , Feminino , Humanos , Masculino , Obesidade/enzimologia , Adulto Jovem
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