RESUMO
The growing process of industrialization was a milestone for world economic evolution. Since the 1940s, social movements have revolutionized green chemistry and provided shifts in industrial positions and sustainable processes with advances in environmental impact and awareness of companies and population. Paul Anastas and John Warner, in the 1990s, postulated the 12 principles of Green Chemistry, which are based on the minimization or non-use of toxic solvents in chemical processes and analyzes, as well as, the non-generation of residues from these processes. One of the most active areas of Research and Development in Green Chemistry is the development of analytical methodologies, giving rise to the so-called Green Analytical Chemistry. The impacts of green chemistry on pharmaceutical analyzes, environmental, population, analyst and company are described in this review and they are multidimensional. Every choice and analytical attitude has consequences both in the final product and in everything that surrounds it. The future of green chemistry as well as our future and the environment is also contemplated in this work.
RESUMO
Bacterial resistance is a growing and worrying factor. The high reproducibility of these resistant microorganisms tends to influence the development of new drugs and research related to product quality control. Among the existing antimicrobials, flucloxacillin (FLU) was designed for oral and injectable administration with bactericidal activity. FLU sodium is the form used in pharmaceutical formulations. It is an antimicrobial resistant against penicillinase, an enzyme responsible for cleaving the beta-lactam ring of penicilins, which leads to inactivity of the drug. Qualitative and quantitative analyzes are essential to ensure quality of pharmaceuticals and health of the population. It is important that quality control is effective and appropriate, only then we can win the battle against microbial resistance. In this work, we want to highlight tthe characteristics of FLU as an important antibiotic and methods for the determination of FLU in pharmaceutical products and biological matrices. Among the analytical methods described in the literature for the determination of FLU, high performance liquid chromatography (HPLC) stands out. Anyway, this method uses toxic solvents (e.g. acetonitrile) long columns, which provide long runs, as well as produces large amounts of waste. Currently, the priority changed to develop ecologically correct, conscious and sustainable methods. This new view on analytical methods should be applied to FLU analyzes and used to develop and improve existing methods.
Assuntos
Técnicas de Química Analítica/métodos , Floxacilina/análise , Floxacilina/farmacologia , Floxacilina/química , Floxacilina/farmacocinéticaRESUMO
Bacterial infections are the second leading cause of global mortality. Considering this fact, it is extremely important studying the antimicrobial agents. Amoxicillin is an antimicrobial agent that belongs to the class of penicillins; it has bactericidal activity and is widely used in the Brazilian health system. In literature, some analytical methods are found for the identification and quantification of this penicillin, which are essential for its quality control, which ensures maintaining the product characteristics, therapeutic efficacy and patient's safety. Thus, this study presents a brief literature review on amoxicillin and the analytical methods developed for the analysis of this drug in official and scientific papers. The major analytical methods found were high-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (U-HPLC), capillary electrophoresis and iodometry and diffuse reflectance infrared Fourier transform. It is essential to note that most of the developed methods used toxic and hazardous solvents, which makes necessary industries and researchers choose to develop environmental-friendly techniques to provide enhanced benefits to environment and staff.
Assuntos
Amoxicilina/análise , Antibacterianos/análise , Infecções Bacterianas/tratamento farmacológico , Química Verde/métodos , Streptococcus/efeitos dos fármacos , Amoxicilina/farmacologia , Antibacterianos/farmacologia , Cromatografia Líquida de Alta Pressão , HumanosRESUMO
Infections are the second leading cause of mortality worldwide and there are many reasons justifying the need for further studies of antimicrobial agents. Cefadroxil is a drug that has bactericidal activity and broad spectrum of action. Quantitative analyzes about cefadroxil are essential for the understanding of bioavailability, bioequivalence, and therapeutic control, which will ensure the product's characteristics and patients' safety. Thus, this study highlights a brief literature review about the drug and the existing methods developed for the determination of cefadroxil found in official and scientific papers. According to the methods found in literature, liquid chromatography and spectrophotometry of absorption in the ultraviolet region prevailed over the others. Importantly, most of the solvents used for the development of the described analytical methods are toxic to the environment, making it necessary to educate researchers and pharmaceutical companies to use nontoxic solvents to provide environmental-friendly methods and better benefits to equipments and mainly to analysts.