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INTRODUCTION: Despite promising results, the effects of transcranial direct current stimulation (tDCS) in the early stages of stroke and its impact on brain activity have been poorly studied. Therefore, this study aimed to investigate the effect of tDCS applied over the ipsilesional motor cortex on resting-state brain activity in the early subacute phase of stroke. METHODS: This is a pilot, randomized, double-blind, proof-of-concept study. The patients with stroke were randomly assigned into two groups: anodal tDCS (A-tDCS) or sham tDCS (S-tDCS). For A-tDCS, the anode was placed over the ipsilesional motor cortex, while the cathode was placed over the left or right supraorbital area (Fp2 for left stroke or Fp1 for right stroke). For the real stimulation, a constant current of 1.0 mA was delivered for 20 min and then ramped down linearly for 30 s, maintaining a resistance below 10 kΩ. For the sham stimulation, the stimulator was turned on, and the current intensity was gradually increased for 30 s, tapered off over 30 s, and maintained for 30 min without stimulation. Each stimulation was performed for three consecutive sessions with an interval of 1 h between them. The primary outcome was spectral electroencephalography (EEG) analysis based on the Power Spectral Density (PSD) determined by EEG records of areas F3, F4, C3, C4, P3, and P4. Brain Vision Analyzer software processed the signals, EEG power spectral density (PSD) was calculated before and after stimulation, and alpha, beta, delta, and theta power were analyzed. The secondary outcomes included hemodynamic variables based on the difference between baseline (D0) and post-intervention session (D1) values of systolic (SBP) and diastolic (DBP) blood pressure, heart rate (HR), respiratory rate (RR) and peripheral oxygen saturation (SPO2). Mann-Whitney test was used to compare position measurements of two independent samples; Fisher's exact test was used to compare two proportions; paired Wilcoxon signed-rank test was used to compare the median differences in the within-group comparison, and Spearman correlations matrix among spectral power analysis between EEG bands was performed to verify consistency of occurrence of oscillations. Statistical significance was set at P < 0.05. RESULTS: An increase in PSD in the alpha frequency in the P4 region was observed after the intervention in the A-tDCS group, as compared to the placebo group (before = 6.13; after = 10.45; p < 0.05). In the beta frequency, an increase in PSD was observed in P4 (before = 4.40; after = 6.79; p < 0.05) and C4 (before = 4.43; after = 6.94; p < 0.05) after intervention in the A-tDCS group. There was a reduction in PSD at delta frequency in C3 (before = 293.8; after = 58.6; p < 0.05) after intervention in the A-tDCS group. In addition, it was observed a strong relationship between alpha and theta power in the A-tDCS group before and after intervention. However, the sham group showed correlations between more power bands (alpha and theta, alpha and delta, and delta and theta) after intervention. There was no difference in hemodynamic variables between the intra- (before and after stimulation) and inter-groups (mean difference). CONCLUSION: Anodal tDCS over the ipsilesional motor cortex had significant effects on the brain electrical activity in the early subacute stroke phase, increasing alpha and beta wave activities in sensorimotor regions while reducing slow delta wave activity in motor regions. These findings highlight the potential of anodal tDCS as a therapeutic intervention in the early stroke phase.

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INTRODUCTION: Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disease that significantly limits an individual's activities of daily living (ADLs) and negatively affects their social participation as it progresses. The impact of activities and participation must be continuously assessed, and the Glittre-ADL is a validated test for MS to assess functional capacity in tasks similar to ADLs. OBJECTIVE: To evaluate whether the Glittre-ADL test is a valid method for assessing functional mobility in individuals with MS and moderate disability or those who use assistive devices. METHODS: This cross-sectional study enrolled 30 individuals in two groups: 1) MS group (n = 15); and 2) healthy control group (n = 15). The MS group underwent three functional mobility tests: 1) Glittre-ADL; 2) Timed 25-Foot Walk (T25FWT); and 3) Timed Up and Go (TUG) while the healthy group underwent only the Glittre-ADL test. RESULTS: An association was found between the Glittre-ADL time and T25FWT (r = 0.78, p < .001) and TUG (r = 0.56, p = .030) times. In the MS group, statistically significant differences were found in time (F = 2.88, p = .038) and speed (F = 5.17, p = .024) between laps. A statistically significant difference was observed between the total time in the MS and control groups (Area Under Curve - AUC: 0.982, p < .0001). A total time > 46.0s represents the reduction of functional performance during ADLs in individuals with MS (sensitivity: 93.3%; specificity: 92.2%). CONCLUSION: The Glittre-ADL test is a valid tool for assessing functional mobility in individuals with MS and mild to moderate disability (EDSS score ≤ 6.5).

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Background: SARS-CoV-2 infection affects multiple systems, including musculoskeletal, neurological, and respiratory systems. Changes associated with physical inactivity due to prolonged hospitalization can affect the functional capacity of individuals with long coronavirus disease 2019 (COVID-19) or post-COVID-19 condition and may cause changes in some postural control functions, such as verticality. Objectives: This study aimed to evaluate the perception of verticality in individuals with long COVID. Design: Cross-sectional study. Methods: This study included 60 participants with post-COVID-19 condition divided into 2 groups: hospitalized group (n = 24), those hospitalized owing to SARS-CoV-2 infection; and non-hospitalized group (n = 36), those infected with SARS-CoV-2 but not hospitalized. All participants were examined using a post-COVID-19 functional status (PCFS), sit-to-stand test, grip strength assessment, painful and tactile sensory assessments, visual acuity assessment, and vestibular assessment. Verticality perception was evaluated using the subjective visual vertical (SVV) and subjective haptic vertical (SHV) tests. In both tests, the absolute values (positive values only) and true values (positive and negative values) were considered. To verify potential confounders that could influence the verticality of the results, logistic regression models were used for categorical variables and multiple linear regressions were used for continuous variables. For analysis between groups, the independent samples test (Mann-Whitney U test) was used. Results: There were no confounders between clinical variables and verticality in either group. There was a significant increase in absolute SVV (mean deviation [MD]: 2.83; P < .0001) and true SVV (MD: -4.18; P = .005) in the hospitalized group compared to the non-hospitalized group. Furthermore, there was a significant increase in the true SHV (MD: -3.6; P = .026) in the hospitalized group compared to that in the non-hospitalized group. Conclusion: Less accurate visual and haptic verticality perception task performance was observed in hospitalized patients with post-COVID-19 condition.

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BACKGROUND: Older adults are benefited from the continuous tactile information to enhance postural control. Therefore, the aim was to evaluate the effect of the haptic anchors during balancing and walking tasks in older adults. METHODS: The search strategy (up to January 2023) was based on the PICOT (older adults; anchor system during balance and walking tasks; any control group; postural control measurements; short and/or long-term effect). Two pairs of reviewers independently examined all titles and abstracts for eligibility. The reviewers independently extracted data from the included studies, assessed the risk of bias, and certainty of the evidence. RESULTS: Six studies were included in the qualitative synthesis. All studies used a 125-g haptic anchor system. Four studies used anchors when standing in a semi-tandem position, two in tandem walking on different surfaces, and one in an upright position after plantar flexor muscle fatigue. Two studies showed that the anchor system reduced body sway. One study showed that the ellipse area was significantly lower for the 50% group (reduced frequency) in the post-practice phase. One study showed that the reduction in the ellipse area was independent of the fatigue condition. Two studies observed reduced trunk acceleration in the frontal plane during tandem waking tasks. The studies had low to moderate certainty of evidence. CONCLUSION: Haptic anchors can reduce postural sway during balance and walking tasks in older adults. Also, positive effects were seen during the delayed post-practice phase after the removal of anchors only in individuals who used a reduced anchor frequency.

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The coronavirus disease 2019 (COVID-19) can disrupt various brain functions. Over a one-year period, we aimed to assess brain activity and cognitive function in 53 COVID-19 patients and 30 individuals without COVID-19 (or asymptomatic). The Montreal Cognitive Assessment, Trail Making Test Parts A and B (TMT-A and B), and Digit Span Test were used to assess cognitive function. Cognitive variables and electroencephalography (EEG) data (activity, mobility, and complexity) were compared between the groups at rest and during cognitive demand (F3-F7, Fz-F3, Fz-F4, and F4-F8). There was a reduction in F3-F7 activity during the TMT-B in the COVID-19 group at 6-12 months compared to the controls (p = 0.01) at baseline (p = 0.03), a reduction in signal complexity at F3-F7 at rest in the COVID-19 group at baseline and 6-12 months compared to the controls (p < 0.001), and a reduction in Fz-F4 activity at rest from 6-12 months in the post-COVID group compared to baseline (p = 0.02) and 3-6 months (p = 0.04). At 6-12 months, there was a time increase in TMT-A in the COVID-19 group compared to that in the controls (p = 0.04). Some correlations were found between EEG data and cognitive test in both groups. In conclusion, there was a reduction in brain activity at rest in the Fz-F4 areas and during high cognitive demands in the F3-F7 areas. A reduction in signal complexity in F3-F7 at rest was found in the COVID-19 group at 6-12 months after acute infection. Furthermore, individuals with COVID-19 experience long-term changes in cognitive function.

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Assessment of cognitive processing speed through choice reaction time (CRT) can be an objective tool to assess cognitive functions after COVID-19 infection. Objective: This study aimed to assess CRT in individuals after acute COVID-19 infection over 1 year. Methods: We prospectively analyzed 30 individuals (male: 9, female: 21) with mild-moderate functional status after COVID-19 and 30 individuals (male: 8, female: 22) without COVID-19. Cognitive and neuropsychiatric symptoms were evaluated using the Montreal Cognitive Assessment (MoCA) and Hospital Anxiety and Depression Scale (HADS), respectively. CRT (milliseconds) was evaluated by finding the difference between the photodiode signal and the electromyographic (EMG) onset latency of anterior deltoid, brachial biceps, and triceps during the task of reaching a luminous target. CRT was evaluated three times over 1 year after COVID-19: baseline assessment (>4 weeks of COVID-19 diagnosis), between 3 and 6 months, and between 6 and 12 months. Results: The multiple comparison analysis shows CRT reduction of the anterior deltoid in the COVID-19 group at 3-6 (p=0.001) and 6-12 months (p<0.001) compared to the control group. We also observed CRT reduction of the triceps at 6-12 months (p=0.002) and brachial biceps at 0-3 (p<0.001), 3-6 (p<0.001), and 6-12 months (p<0.001) in the COVID-19 compared to the control group. Moderate correlations were observed between MoCA and CRT of the anterior deltoid (r=-0.63; p=0.002) and brachial biceps (r=-0.67; p=0.001) at 6-12 months in the COVID-19 group. Conclusions: There was a reduction in CRT after acute COVID-19 over 1 year. A negative correlation was also observed between MoCA and CRT only from 6 to 12 months after COVID-19 infection.

A avaliação da velocidade de processamento cognitivo por meio do tempo de reação de escolha (TRE) pode ser uma ferramenta objetiva para acompanhar as alterações cognitivas após a COVID-19. Objetivo: Avaliar o TRE em pacientes após infecção aguda por COVID-19 ao longo de um ano. Métodos: Foram avaliados 30 indivíduos (sexo masculino: nove; feminino: 21) com estado funcional leve-moderado após infecção por COVID-19 e 30 (sexo masculino: oito; feminino: 22) sem COVID-19. A avaliação foi feita pelo Montreal Cognitive Assessment (MoCA) e pela Escala Hospitalar de Ansiedade e Depressão. O TRE (milissegundos) foi avaliado pela diferença entre o sinal luminoso e a latência de início da atividade muscular (EMG) do deltoide anterior (DA), do bíceps braquial (BB) e do tríceps durante uma tarefa de alcance. O TRE foi avaliado ao longo de um ano: avaliação inicial (>4 semanas após diagnóstico de COVID-19), em 3­6 meses e em 6­12 meses. Resultados: Houve redução do TRE do DA no grupo COVID-19 em 3­6 meses (p=0,001) e 6­12 meses (p<0,001) em comparação com o grupo de controle. Também foi observada redução na TRE do tríceps em 6­12 meses (p=0,002) e do BB em 0­3 meses (p<0,001), 3­6 meses (p<0,001) e 6­12 meses (p<0,001) no grupo COVID-19 em comparação com o grupo de controle. Correlações moderadas foram observadas entre MoCA e TRE do DA (r=-0,63; p=0,002) e BB (r=-0,67; p=0,001) aos 6­12 meses no grupo COVID-19. Conclusões: Houve redução do TRE após COVID-19 ao longo de um ano, além de correlação negativa entre MoCA e TRE no período de seis a 12 meses após COVID-19.

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INTRODUCTION: To understand the current practices in stroke evaluation, the main clinical decision support system and artificial intelligence (AI) technologies need to be understood to assist the therapist in obtaining better insights about impairments and level of activity and participation in persons with stroke during rehabilitation. METHODS: This scoping review maps the use of AI for the functional evaluation of persons with stroke; the context involves any setting of rehabilitation. Data were extracted from CENTRAL, MEDLINE, EMBASE, LILACS, CINAHL, PEDRO Web of Science, IEEE Xplore, AAAI Publications, ACM Digital Library, MathSciNet, and arXiv up to January 2021. The data obtained from the literature review were summarized in a single dataset in which each reference paper was considered as an instance, and the study characteristics were considered as attributes. The attributes used for the multiple correspondence analysis were publication year, study type, sample size, age, stroke phase, stroke type, functional status, AI type, and AI function. RESULTS: Forty-four studies were included. The analysis showed that spasticity analysis based on ML techniques was used for the cases of stroke with moderate functional status. The techniques of deep learning and pressure sensors were used for gait analysis. Machine learning techniques and algorithms were used for upper limb and reaching analyses. The inertial measurement unit technique was applied in studies where the functional status was between mild and severe. The fuzzy logic technique was used for activity classifiers. CONCLUSION: The prevailing research themes demonstrated the growing utility of AI algorithms for stroke evaluation.

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OBJECTIVES: This study aimed to evaluate the effect of anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) in addition to visuomotor training (VMT) on choice reaction time (CRT) and cognitive function in amateur soccer players. DESIGN: Single-center, randomized, placebo-controlled, double-blind, parallel-group study. SETTING: Neuroscience and Motor Control Laboratory. PARTICIPANTS: Thirty Brazilian male amateur soccer players, aged 18-30 years. MAIN OUTCOME MEASURES: Participants were allocated to the intervention or control groups. Both groups performed VMT, but the intervention group additionally underwent anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC; F3). The cathodal electrode was positioned in the right supraorbital region (Fp2). The tDCS was applied at 2 mA for 20 min for five consecutive sessions (24 h intervals). The VMT protocol was delivered during the application of tDCS and was composed of kicking a ball for 10 min (between the fifth and fifteenth minutes of the 20 min of tDCS application). The primary outcome was assessed based on changes in CRT during reaching (non-trained limb) and kicking (trained limb) tasks. Secondary outcomes were overall cognitive function measured by the Trail Making Test part A (TMT-A) and part B (TMT-B), and Digit Span Test forward (DSF) and backward (DSB) scores. All outcomes were evaluated before and after the intervention. RESULTS: In the primary outcomes, compared with the control group, the anodal tDCS combined with VMT group had greater reduction in CRT for the rectus femoris (p = 0.007) adjusted for age and baseline performance (F (1,26) = 22,23; p < 0,001) and for the triceps (p = 0.039) adjusted for training frequency (days/week) and baseline performance (F (1,26) = 5,70; p = 0,016). No differences were observed in the CRT of other muscles (anterior deltoid [p = 0.181], brachial biceps [p = 0.130], and vastus medialis [p = 0.074]). And, there were no differences between the groups in terms of cognitive function (TMT-A [p = 0.062]; TMT-B [p = 0.320]; DSF [p = 0.102]; DSB [p = 0.345]). CONCLUSION: Anodal tDCS over the left DLPFC in addition to visuomotor training of a functional task can be an efficient tool for athletes to decrease the CRT of the rectus femoris (trained limb) and triceps (non-trained limb); however, there were no differences between the groups in the others muscles (anterior deltoid, brachial biceps, and vastus medialis), and in terms of cognitive function.

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INTRODUCTION: Post-stroke individuals usually present a delay in choice reaction time (CRT), and it would be important to verify the efficacy in the reduction of CRT after intervention protocols. OBJECTIVE: The main question of this review is 'What are the characteristics of the CRT test and the interventions that decrease the CRT?' STUDY DESIGN: Systematic review. METHODS: The search was performed in March 2019 using the electronic databases, PubMed, Science Direct, Scopus, Web of Science, Lilacs, Cinahal, Cochrane, Ovid, Scielo, PEDro, and Embase. There was no restriction regarding publication dates, and studies written in English that were conducted on poststroke patients and presented CRT results were included. RESULTS: Six studies were included in this systematic review, and the majority showed varied objectives, methodologies, and groups, regarding the number and characteristics of the sample, varying from complex to simple tasks for the CRT evaluation. CONCLUSION: This review suggests the investigation of the CRT in stroke patients with functional tasks using auditory and/or visual stimulus. About the CRT training in stroke patients, this review also suggests bilateral training, including functional tasks, and the use of structural practice blocks, but more studies are needed to better demonstrate the effects of interventions on the CRT. REGISTRATION NUMBER: PROSPERO (protocol no. CRD42017073995).

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BACKGROUND: Among the tools used for motor rehabilitation after stroke, transcranial direct current electrical stimulation (tDCS) aims to modify cortical excitability and improve motor function. Despite promising results, the effects of tDCS on balance after stroke have not yet been assessed using specific protocols. Therefore, this study will aim to evaluate the effects of tDCS and rehabilitation on balance after stroke. METHODS: Eighty-two ischemic stroke patients across two inpatient rehabilitation sites in Brazil will be randomized into one of two treatment programs (anodic tDCS and sham tDCS), both associated with balance training, each 2 days/week, for six weeks and monitored for exertion, repetition and quality of movements. The primary outcome measure is the balance. Secondary outcomes will include clinical and functional measures. Outcome data will be assessed at two time points. DISCUSSION: This trial will contribute to clarify if anodal tDCS is effective when associated with balance training to stroke recovery.

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