RESUMO

This article reviews the contemporary and inclusive definition of cancer survivorship, including patients with and without disease who have completed or continue to undergo treatment. The Spanish Society of Medical Oncology (SEOM) describes in this article the needs of these patients and outlines a care model based on an estimation of cancer incidence and identification of patient needs, to enable the provision of practical actions to achieve effective care. The objectives of this review are to identify the main effects of cancer on survivors and to establish appropriate ways of measuring these effects, as well as discussing the management of physical, psychological and social, occupational, financial, and other health-related needs. We suggest a multidisciplinary care model and training programs for the different professionals involved in care, and highlight challenges and the future role of the SEOM and health-care policy in ensuring optimum care of cancer survivors.

RESUMO

This revised consensus statement of the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathological Anatomy (SEAP) updates the recommendations for biomarkers use in the diagnosis and treatment of breast cancer that we first published in 2018. The expert group recommends determining in early breast cancer the estrogen receptor (ER), progesterone receptor (PR), Ki-67, and Human Epidermal growth factor Receptor 2 (HER2), as well as BReast CAncer (BRCA) genes in high-risk HER2-negative breast cancer, to assist prognosis and help in indicating the therapeutic options, including hormone therapy, chemotherapy, anti-HER2 therapy, and other targeted therapies. One of the four available genetic prognostic platforms (Oncotype DX®, MammaPrint®, Prosigna®, or EndoPredict®) may be used in ER-positive patients with early breast cancer to establish a prognostic category and help decide with the patient whether adjuvant treatment may be limited to hormonal therapy. In second-line advanced breast cancer, in addition, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and estrogen receptor 1 (ESR1) should be tested in hormone-sensitive cases, BRCA gene mutations in HER2-negative cancers, and in triple-negative breast cancer (TNBC), programmed cell death-1 ligand (PD-L1). Newer biomarkers and technologies, including tumor-infiltrating lymphocytes (TILs), homologous recombination deficiency (HRD) testing, serine/threonine kinase (AKT) pathway activation, and next-generation sequencing (NGS), are at this point investigational.

RESUMO

El presente trabajo de investigación de tipo cuantitativo, descriptivo correlacional, de corte transversal, tuvo como objetivo determinar la relación entre el estilo de vida y los factores biosocioculturales del adulto mayor del asentamiento humano "San Juan"-Chimbote, 2012. La muestra estuvo conformada por 84 personas adultas mayores de ambos sexos. La recolección de datos se efectuó a través de las visitas domiciliarias teniendo como instrumento la escala del estilo de vida y el cuestionario semi-estructurado sobre factores biosocioculturales. (El análisis de datos se efectuó mediante la prueba de independencia del Chi cuadrado (χ²) con el 95% confiabilidad y significancia de p<0,05. La mayoría de los adultos mayores tiene un estilo de vida no saludable; sin embargo, existe un porcentaje significativo con estilo de vida saludable. Respecto a los factores biosocioculturales, un poco más de la mitad fueron masculinos; la mayoría tiene grado de instrucción primaría completa e incompleta; cuentan con un ingreso económico de 100 a 599 Nuevos Soles; son viudos y con unión libre; más de la mitad son evangélicos. No existe relación significativa entre el estilo de vida y los factores biosocioculturales: sexo, grado de instrucción, religión estado civil e ingreso económico; pero sí existe relación significativa con el factor social de ocupación de los adultos mayores.

This non-experimental research of descriptive corelational desing aimed to establish the relationship between life style and sociocultural factors of the elderly people in the human settlemen San Juan - Chimbote. The sample consisted of 84 elderly people, males an females who were visited at home. The instruments used were the life style scale and sociocultural factors questionnaire. The data was statistically analyzed y means of the Chi Square test for independence with a 5% significance level and 95% of reliability. The study came to the followig conclusions: Most of elderly people present unhealthy lifestyle, however, a significant number of the present healthy one. Respect to the biosociocultural factors, most are male. Most have completed and non-completed primary education. Their salary range from 100and 599 Nuevos Soles monthly. Most of them are widowed and widowers. More than half are evangelists. There is no significant relationship between lifestyle and the sociocultural factors: sex, education level, religion, marital status, and income; but there is significant relation between elderly people's occupation.

Assuntos

RESUMO

We report the case of a 42 year-old woman with myasthenia gravis associated with a malignant thymoma. Despite surgery, chemotherapy and radiotherapy, the thymoma showed soft tissues, pleural and mediastinic progression. Unexpectedly, a complete remission of the thymoma was confirmed by FDG-PET after four cycles of immunoglobulins, administered as treatment for a myasthenic crisis. To our knowledge this is the first case report of complete remission of a malignant thymoma with immunoglobulin therapy.

Assuntos