RESUMO
OBJECTIVE: The association between Papillary Thyroid Carcinoma (PTC) and coexistent Hashimoto's Thyroiditis (HT) was controversial. The purpose of this study was to evaluate the presence of HT exerts any influence on the aggressiveness of PTC, and to establish a nomogram for predicting the possibility of aggressiveness in PTC. METHODS: 373 consecutive PTC patients with/without coexistent HT from January 2017 to December 2020 were retrospective reviewed. Patients' clinicopathologic and sonographic characteristics were collected for univariate and multivariate analyses. A nomogram was established based on the risk factors for aggressiveness in PTC. RESULTS: Male (pâ¯=â¯0.001), tumor size >1.0â¯cm (pâ¯=â¯0.046) and lymph node metastasis (pâ¯=â¯0.018) were negatively associated with PTC coexisted with HT, while it was significantly positively associated with the frequence of multifocality (pâ¯=â¯0.010). Univariate and multivariate analyses suggested that age ≥55 years (pâ¯=â¯0.000), male (pâ¯=â¯0.027), HT (pâ¯=â¯0.017), tumor size >1.0â¯cm (pâ¯=â¯0.015), multifocality (pâ¯=â¯0.041), distance to capsular ≤0â¯cm (pâ¯=â¯0.050) and blood flow (Grade I: pâ¯=â¯0.044) were independent risk factors for predicting the aggressiveness in PTC. A nomogram according to these predictors was further developed and validated. The receiver operating characteristic curve (AUCâ¯=â¯0.734 and 0.809 for training and validation cohorts, respectively) and decision curve analyses indicated that the nomogram model was clinically useful. The calibration curve revealed that the nomogram exhibited an excellent consistency. CONCLUSIONS: In this study, the coexistent HT might play a protective role in preventing the proliferation of PTC. Dispensable aggressive treatment may be reduced in PTC by pre-operative identification of sonographic and clinical characteristics and incorporating with the predicted nomogram model.
Assuntos
Doença de Hashimoto , Nomogramas , Câncer Papilífero da Tireoide , Neoplasias da Glândula Tireoide , Ultrassonografia , Humanos , Masculino , Doença de Hashimoto/complicações , Doença de Hashimoto/diagnóstico por imagem , Doença de Hashimoto/patologia , Pessoa de Meia-Idade , Feminino , Estudos Retrospectivos , Adulto , Câncer Papilífero da Tireoide/diagnóstico por imagem , Câncer Papilífero da Tireoide/patologia , Câncer Papilífero da Tireoide/complicações , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide/complicações , Fatores de Risco , Idoso , Adulto Jovem , Metástase Linfática/diagnóstico por imagemRESUMO
NADPH oxidase enzymes (NOX) are involved in all stages of carcinogenesis, but their expression levels and prognostic value in breast cancer (BC) remain unclear. Thus, we aimed to assess the expression and prognostic value of NOX enzymes in BC samples using online databases. For this, mRNA expression from 290 normal breast tissue samples and 1904 BC samples obtained from studies on cBioPortal, Kaplan-Meier Plotter, and The Human Protein Atlas were analyzed. We found higher levels of NOX2, NOX4, and Dual oxidase 1 (DUOX1) in normal breast tissue. NOX1, NOX2, and NOX4 exhibited higher expression in BC, except for the basal subtype, where NOX4 expression was lower. DUOX1 mRNA levels were lower in all BC subtypes. NOX2, NOX4, and NOX5 mRNA levels increased with tumor progression stages, while NOX1 and DUOX1 expression decreased in more advanced stages. Moreover, patients with low expression of NOX1, NOX4, and DUOX1 had lower survival rates than those with high expression of these enzymes. In conclusion, our data suggest an overexpression of NOX enzymes in breast cancer, with certain isoforms showing a positive correlation with tumor progression.
Assuntos
Neoplasias da Mama , NADPH Oxidases , Humanos , Feminino , NADPH Oxidases/genética , NADPH Oxidases/metabolismo , Oxidases Duais/genética , Neoplasias da Mama/genética , Prognóstico , Espécies Reativas de Oxigênio/metabolismo , RNA Mensageiro/genética , Expressão Gênica , NADPH Oxidase 4/genética , NADPH Oxidase 1/genéticaRESUMO
Abstract In Brazil, reflective practice groups and groups for the liability of men who commit violence against women represent a public policy with good results in reducing violence between intimate partners. This study aimed to assess the contributions of a reflective practice group on feelings such as empathy, aggressiveness and anger in men who commit violent crimes against women. Using the Empathy Scale - ACME, the Aggression Tendency Assessment Scale - EATA, the State-Trait Anger Expression Inventory 2 - STAXI 2 and a sociodemographic questionnaire, a quantitative study was carried out with 80 men divided into a reflective practice group and a control group. It was found that the members of the reflective group showed a decrease in mean aggressiveness and an increase in mean empathy compared with the control group. It is suggested that empathy, aggressiveness and anger be integrated into interventions using active methodologies.
Resumo No Brasil, os grupos reflexivos e de responsabilização para homens autores de violência contra a mulher representam uma política pública com bons resultados na redução da violência entre parceiros íntimos. Este estudo objetivou avaliar as contribuições de um grupo reflexivo na empatia, agressividade e raiva em homens autores de violência contra a mulher. Utilizando a Escala de empatia - ACME, a Escala para Avaliação de Tendência à Agressividade - EATA, O Inventário de Expressão de Raiva como Estado de Traço - STAXI 2 e um Questionário sociodemográfico foi realizado um estudo quantitativo com 80 homens, divididos em grupo reflexivo e grupo controle. Verificou-se que os integrantes do grupo reflexivo apresentaram diminuição nas médias de agressividade e aumento nas médias de empatia quando comparados com o grupo controle. Sugere-se integrar empatia, agressividade e raiva nas intervenções do grupo reflexivo por meio de metodologias ativas.
Resumen En Brasil, los grupos de reflexión y responsabilización para hombres perpetradores de violencia contra la mujer son una política pública con buenos resultados en la reducción de la violencia entre parejas. Este estudio tuvo como objetivo evaluar las contribuciones de un grupo de reflexión sobre la empatía, la agresividad y la ira a hombres perpetradores de violencia contra la mujer. Utilizando la Escala de Empatía - ACME -, la Escala de Evaluación de Tendencias Agresivas - EATA -, el Inventario de Expresión de Ira como Estado Rasgo - STAXI 2 - y un cuestionario sociodemográfico, se realizó un estudio cuantitativo con 80 hombres, divididos en grupo de reflexión y de control. Se encontró que los integrantes del grupo tuvieron reducción en los promedios de agresividad y aumento en los promedios de empatía en comparación con el grupo de control. Se sugiere integrar empatía, agresión e ira en las intervenciones mediante metodologías activas.
RESUMO
O objetivo do estudo foi realizar uma revisão sistemática da literatura acerca do comportamento antissocial online e, também, categorizar esses comportamentos e observar aspectos psicossociais relacionados. Para tanto, foi utilizada uma síntese qualitativa, incluindo estudos quantitativos publicados entre 2016-2020 nas bases de dados Scopus, PsycInfo, Pepsic e Scielo. Vinte e cinco estudos se adequaram às análises. Os resultados demonstraram a existência de quatro categorias de comportamento antissocial online: cyberbullying, trollagem, comportamento antissocial sexual, e cyberstalking. A tétrade sombria (narcisismo, psicopatia, Maquiavelismo e sadismo) mostrou-se o preditor mais consistente dessas categorias nos estudos. O estudo alcançou os objetivos propostos, preenchendo duas lacunas: a inexistência de categorização do comportamento antissocial online e a escassez de estudos brasileiros sobre o tema
The study aimed to conduct a systematic literature review on antisocial online behavior. The objective was also to categorize these behaviors and observe related psychosocial aspects. To this end, a qualitative synthesis was used, including quantitative studies published between 2016-2020 in the Scopus, PsycInfo, Pepsic, and Scielo databases. 25 studies fitted the analyzes. The results demonstrated the existence of four antisocial online behavior categories: cyberbullying, trolling, sexual antisocial behavior, and cyberstalking. The dark tetrad (narcissism, sychopathy, Machiavellianism, and sadism) was the most consistent predictor of these categories among studies. The research fulfilled the proposed purposes, filling two literature gaps: The lack of categorization of antisocial online behavior; and the scarcity of Brazilian studies on the topic
El objetivo del estudio fue realizar una revisión sistemática de la literatura sobre el comportamiento antisocial online. El objetivo también fue categorizar estos comportamientos y observar aspectos psicosociales relacionados. Para ello, se utilizó una síntesis cualitativa, incluyendo estudios cuantitativos publicados entre 2016-2020 en las bases de datos Scopus, PsycInfo, Pepsic y Scielo. 25 estudios se ajustan a los análisis. Los resultados demostraron la existencia de cuatro categorías de comportamiento antisocial en línea: cyberbullying, trolling, comportamiento sexual antisocial y cyberstalking. La tétrada oscura (narcisismo, psicopatía, maquiavelismo y sadismo) fue el predictor más consistente de estas categorías entre los estudios. El estudio cumplió con los objetivos propuestos, llenando dos vacíos: La falta de categorización de la conducta antisocial en línea; y la escasez de estudios brasileños sobre el tema
Assuntos
Humanos , AgressãoRESUMO
Este estudo tem como objetivo analisar o perfil dos homens autores de violência contra as mulheres na literatura científica brasileira, intencionando auxiliar no direcionamento de práticas socioeducativas das políticas públicas no enfren-tamento desse tipo de violência. O estudo proposto configura uma revisão sistemática realizada por meio dos descritores "violência contra a mulher", "autor de violência", "violência por parceiro íntimo" e "violência doméstica contra a mulher". As bases de dados pesquisadas foram: SciELO, Oasisbr e BVS, compondo a amostra final de 15 artigos. Diante dos estudos que compuseram o estudo, verifica-se características como idade, situação laboral, escolari-dade, uso de álcool e outras drogas, além de histórico de violência familiar. Evidencia-se que o perfil identificado neste artigo apresenta divergências entre pontos das pesquisas nacionais realizadas. Com isso, recomenda-se a formu-lação de um instrumento que uniformize as investigações acerca da temática, assim como a participação ativa de homens autores de violência nas pesquisas. (AU)
This study aims to analyze the profile of men who commit violence against women in Brazilian scientific literature, with the intention of aiding in the development of socio-educational practices within public policies to address this type of violence. The proposed study constitutes a systematic review conducted using the descriptors "violence against women," "perpetrators of violence," "intimate partner violence," and "domestic violence against women." The data-bases searched included SciELO, Oasisbr, and BVS, resulting in a final sample of 15 articles. Based on the studies included in the review, characteristics such as age, employment status, education, and substance use (including alcohol and other drugs), as well as a history of family violence were examined. It is evident that the profile identified in this article presents variations among different national research findings. Consequently, it is recommended to develop an instrument that standardizes investigations on this subject, as well as to actively involve male perpetrators of violence in research. (AU)
Este estudio tiene como objetivo analizar el perfil de los hombres autores de violencia contra las mujeres en la literatura científica brasileña, con la intención de ayudar a orientar las prácticas socioeducativas de las políticas públicas en el tratamiento de este tipo de violencia. El estudio propuesto es una revisión sistemática realizada utilizando los descriptores "violencia contra la mujer", "perpetradores de violencia", "violencia de pareja íntima" y "violencia doméstica contra la mujer". Las bases de datos pesquisadas fueron: SciELO, Oasisbr y BVS, componiendo la muestra final de 15 artículos. En vista de los artículos que integraron el estudio, se verificaron características como edad, situación laboral, escolaridad, uso de alcohol y otras drogas, además de ante-cedentes de violencia familiar. Se evidencia que el perfil identificado en este artículo presenta diferencias entre los puntos de las investigaciones nacionales realizadas. Con esto, se recomienda la formulación de un instrumento que estandarice las investigaciones sobre el tema, así como la participación de hombres perpetradores de violencia en las investigaciones. (AU)
Assuntos
Humanos , Masculino , Violência contra a Mulher , Violência por Parceiro Íntimo , Homens/psicologia , Cônjuges/psicologia , AgressãoRESUMO
(analítico) La investigación sobre agresividad en jóvenes delincuentes es insuficiente en Colombia y, en consecuencia, no hay suficiente información sobre las diferencias de género en esta población. No evaluar e intervenir este comportamiento desde un enfoque de diferencias sexuales impacta negativamente la efectividad de las políticas criminales. En esta investigación participaron 1050 jóvenes infractores, seleccionados por conveniencia. Se incluyeron 855 hombres y 195 mujeres de 14 a 19 años de edad residentes en Medellín (Antioquia). Los principales resultados fueron: 1) muy altos niveles de agresividad proactiva, reactiva y total en los adolescentes infractores; 2) la existencia de diferencias en la agresividad proactiva y agresividad total en las mujeres comparadas con los hombres; y 3) la variación de la agresividad de acuerdo con ciertas variables sociodemográficas y asociadas con el delito.
(analytical) Research on aggressiveness among young offenders is insufficient in Colombia and, consequently, there is not enough information on gender differences related to aggression for this population. Failure to evaluate and intervene with this behavior using a gender perspective negatively impacts the effectiveness of criminal policies. A total of 1050 young offenders, selected based on ease of access, participated in this research study. The population consisted of 855 males and 195 females between 14 and 19 years of age living in Medellín. The main results were: 1) there were very high levels of proactive, reactive and total aggressiveness in adolescent offenders; 2) there were differences in proactive aggressiveness and total aggressiveness in females compared to males; and 3) levels of aggressiveness varied depending on certain sociodemographic and crime-associated variables.
(analítico) A pesquisa sobre a agressividade em jovens infratores é insuficiente na Colômbia e, conseqüentemente, não há informações suficientes sobre as diferenças de gênero nesta população. Não avaliar e intervir neste comportamento a partir de uma perspectiva de gênero tem um impacto negativo na eficácia das políticas criminais. Esta pesquisa envolveu 1050 jovens infratores, selecionados por conveniência. Entre eles estavam 855 homens e 195 mulheres entre 14 e 19 anos de idade morando em Medellín. Os principais resultados foram: 1) níveis muito altos de agressividade proativa, reativa e total nos adolescentes infratores; 2) a existência de diferenças na agressividade proativa e total nas mulheres em comparação com os homens, e 3) a variação da agressividade de acordo com certas variáveis sociodemográficas e relacionadas ao crime.
Assuntos
Psicotrópicos , Adolescente , Violência DomésticaRESUMO
Adenoid cystic carcinoma (ACC) has been reported as the second most common carcinoma of the salivary glands. Few studies have associated miRNA expression with ACC aggressiveness. In this study, we evaluated the miRNA profile of formalin-fixed, paraffin-embedded (FFPE) samples of salivary gland ACC patients using the NanoString platform. We studied the miRNA expression levels associated with the solid growth pattern, the more aggressive histologic feature of ACCs, compared with the tubular and cribriform growth patterns. Moreover, the perineural invasion status, a common clinicopathological feature of the disease that is frequently associated with the clinical progression of ACC, was investigated. The miRNAs showing significant differences between the study groups were selected for target prediction and functional enrichment, which included associations with the disease according to dedicated databases. We observed decreased expression of miR-181d, miR-23b, miR-455, miR-154-5p, and miR-409 in the solid growth pattern compared with tubular and cribriform growth patterns. In contrast, miR-29c, miR-140, miR-195, miR-24, miR-143, and miR-21 were overexpressed in patients with perineural invasion. Several target genes of the miRNAs identified have been associated with molecular processes involved in cell proliferation, apoptosis, and tumor progression. Together, these findings allowed the characterization of miRNAs potentially associated with aggressiveness in salivary gland adenoid cystic carcinoma. Our results highlight important new miRNA expression profiles involved in ACC carcinogenesis that could be associated with the aggressive behavior of this tumor type.
Assuntos
Carcinoma Adenoide Cístico , MicroRNAs , Neoplasias das Glândulas Salivares , Humanos , Carcinoma Adenoide Cístico/genética , Carcinoma Adenoide Cístico/metabolismo , Carcinoma Adenoide Cístico/patologia , MicroRNAs/genética , Neoplasias das Glândulas Salivares/genética , Neoplasias das Glândulas Salivares/metabolismo , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares/metabolismo , Carcinogênese/genéticaRESUMO
Limbic surgery is one of the most attractive and retaken fields of functional neurosurgery in the last two decades. Psychiatric surgery emerged from the incipient work of Moniz and Lima lesioning the prefrontal cortex in agitated patients. Since the onset of stereotactic and functional neurosurgery with Spiegel and Wycis, the treatment of mental diseases gave attention to refractory illnesses mainly with the use of thalamotomies. Neurosis and some psychotic symptoms were treated by them. Several indications when lesioning the brain were included: obsessive-compulsive disorder, depression, and aggressiveness among others with a diversity of targets. The indiscriminately use of anatomical sites without enough scientific evidence, and uncertainly defined criteria for selecting patients merged with a deficiency in ethical aspects, brought a lack of procedures for a long time: only select clinics allowed this surgery around the world from 1950 to the 1990s. In 1999, Nuttin et al. began a new chapter in limbic surgery with the use of Deep Brain Stimulation, based on the experience of pain, Parkinson's disease, and epilepsy. The efforts were focused on different targets to treat depression and obsessive-compulsive disorders. Nevertheless, other diseases were added to use neuromodulation. The goal of this article is to show the new opportunities to treat neuropsychiatric diseases.
RESUMO
La agresividad se ha reconocido como prevalente en la población adolescente, debido a su carácter impulsivo y de inestabilidad emocional, que también caracteriza a la adolescencia. Ello lleva a la necesidad de conocer la frecuencia y la relación de los factores de riesgo de la agresividad en población adolescente, explorando sus diferencias según sexo. Así, esta investigación de enfoque cuantitativo, diseño no experimental, transversal de alcance correlacional, estudió la presencia y las relaciones entre la agresividad y sus factores de riesgo en 212 mujeres y 188 hombres adolescentes, entre 12 y 17 años de edad. Para lo cual, se aplicó una ficha de valoración de factores de riesgo y el cuestionario de agresividad premeditada e impulsiva (CAPI-A). Los hallazgos muestran mayor prevalencia de agresividad impulsiva, y la presencia de más relaciones con factores de riesgo en mujeres respecto a los hombres. Los factores de riesgos relevantes en las mujeres son las actitudes hacia la norma, la percepción sobre la agresividad y los sentimientos; en los hombres, las conductas de riesgo y los sentimientos. Esto resulta de utilidad para la comprensión de la agresividad como pauta comportamental, y el diseño de intervenciones preventivas de la agresividad y sus consecuencias.
The aggressiveness has been recognized as prevalent in teenage population due to their impulsive character, with that emotional instability which characterizes adolescence. This conducts to the need of knowing the frequency and the relationship of risk factors of aggressiveness in teenage population, exploring their differences according to sex. Thus, this research of quantitative approach, non-experimental design, cross-sectional of correlational scope, studied the presence and the relations between aggressiveness and its risk factors in 212 teenage women and 188 teenage men between 12 and 17 years of age. For this, a record card of risk factor evaluation was implemented along with the questionnaire of premediated / impulsive aggressiveness (CAPI-A in Spanish). The findings show a higher prevalence of impulsive aggressiveness and the presence of more relations to risk factors in women than in men. The relevant risk factors in women are the attitudes towards norms, the perception about aggressiveness and the feelings; in men, risk conducts and feelings are the ones to mention. These results useful for the comprehension of aggressiveness as a behavioral pattern, and the design of preventive interventions towards aggressiveness and their consequences.