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BACKGROUND: Much has been said by actors from different fields and perspectives about the manifold changes in world affairs triggered by the COVID-19 pandemic. In this context, it is to be expected that there will be impacts on long-standing partnerships such as the one between the European Union and the Community of Latin American and Caribbean Countries. However, few studies have demonstrated these impacts, either empirically, by uncovering their specificities or from a historical perspective, to allow for a reasonable methodological comparison of the patterns used to define the partnership and that have changed or have been affected in some way by the pandemic. RESULTS: Through an in-depth qualitative assessment of primary and secondary sources, this article contributes to this research gap. It analyzes the patterns and changes or impacts in light of two strands of behavior that can make sense of EU-CELAC health cooperation-revisionist or reformist. The findings show an economy-driven health agenda as a new pattern of cooperation, which derives from EU reformist behavior after the pandemic. CONCLUSIONS: The EU power to enforce its priorities in the context of health cooperation with CELAC is the main factor that will define how (and not just which) competing interests and capacities will be accommodated. The relevance of the study to the fields of global governance for health, interregional health cooperation and EU foreign policy is threefold. It shows us i.how two more international regimes are easily intertwined with health-trade and intellectual property-with the potential to deepen asymmetries and divergences even between long-standing strategic partners; ii.contrary to the idea that reformist behaviors are only adopted by actors who are dissatisfied with the status quo, the study shows us that the reformist actor can also be the one who has more material power and influence and who nevertheless challenges the success of cooperation in the name of new priorities and the means to achieve them; and iii.how the EU will find it difficult to operationalize its new priorities internally, among states and private actors, and with those of CELAC, given the history of intense disputes over health-related economic aspects.

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Due to their tissue structure similar to mammalian skin and their close evolutionary relationship with chordates, holothurians (Echinodermata: Holothuroidea) are particularly interesting for studies on wound healing. However, previous studies dealing with holothuroid wound healing have had limited approaches, being restricted to tissue repair or perivisceral immune response. In this study, we combined tissue, cellular and humoral parameters to study the wound healing process of Holothuria grisea. The immune responses of the perivisceral coelom were assessed by analyzing the number, proportion and viability of coelomocytes and the volume and protein concentration of the coelomic fluid. Additionally, the morphology of the healing tissue and number of coelomocytes in the connective tissue of different body wall layers were examined over 30 days. Our results showed that perivisceral reactions started 3 h after injury and decreased to baseline levels within 24 h. In contrast, tissue responses were delayed, beginning after 12 h and returning to baseline levels only after day 10. The number of coelomocytes in the connective tissue suggests a potential cooperation between these cells during wound healing: phagocytes and acidophilic spherulocytes act together in tissue clearance/homeostasis, whereas fibroblast-like and morula cells cooperate in tissue remodeling. Finally, our results indicate that the major phases observed in mammalian wound healing are also observed in H. grisea, despite occurring at a different timing, which might provide insights for future studies. Based on these data, we propose a model that explains the entire healing process in H. grisea.

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Objetivo: compreender a participação da IA nos diagnósticos da saúde moderna e definir limites para sua aplicação. Metodologia: Revisão integrativa da literatura. A busca dos estudos se deu nas bases de dados LILACS, MEDLINE e SCIELO e foram selecionados artigos científicos, sem recorte temporal e de idioma. Resultados: A inteligência artificial impacta a medicina em três níveis: otimiza a interpretação de imagens para os médicos, aprimora o fluxo de trabalho reduzindo potenciais erros para os sistemas de saúde e capacita os pacientes a processarem seus próprios dados para promover a saúde. Contudo, é necessária atenção aos dados gerados, pois podem desencadear erros em cascata e expor informações sensíveis dos usuários do sistema de saúde. Conclusão: Atribuir à IA a responsabilidade de escolhas e funções desempenhadas por humanos é intrinsecamente perigoso, apesar de sua contribuição inegável nos processos diagnósticos. Sugere-se a realização de pesquisas robustas para compreender plenamente o impacto dessa nova era tecnológica proporcionada pela IA na área da saúde.

Objective: To understand the role of AI in modern healthcare diagnostics and define boundaries for its application. Methodology:Integrative literature review. Studies were searched in the LILACS, MEDLINE, and SCIELO databases, selecting scientific articles without temporal or language restrictions. Results: Artificial intelligence impacts medicine at three levels: it optimizes image interpretation for physicians, enhances workflow by reducing potential errors for healthcare systems, and empowers patients to process their own data to promote health. However, attention is required regarding the generated data, as it may trigger cascading errors and expose sensitive information of healthcare system users. Conclusion: Assigning AI, the responsibility of choices and functions performed by humans is inherently dangerous, despite its undeniable contribution to diagnostic processes. Robust research is suggested to fully understand the impact of this new technological era provided by AI in healthcare.

Objetivo: Comprender la participación de la IA en los diagnósticos de la salud moderna y definir límites para su aplicación. Metodología:Revisión integrativa de la literatura. Los estudios se buscaron en las bases de datos LILACS, MEDLINE y SCIELO, seleccionando artículos científicos sin restricciones temporales ni lingüísticas. Resultados: La inteligencia artificial impacta la medicina en tres niveles: optimiza la interpretación de imágenes para los médicos, mejora el flujo de trabajo al reducir errores potenciales para los sistemas de salud y capacita a los pacientes para procesar sus propios datos y promover la salud. Sin embargo, se requiere atención respecto a los datos generados, ya que pueden desencadenar errores en cascada y exponer información sensible de los usuarios del sistema de salud. Conclusión: Asignar a la IA la responsabilidad de decisiones y funciones realizadas por humanos es intrínsecamente peligroso, apesar de su contribución innegable a los procesos de diagnóstico. Se sugiere realizar investigaciones sólidas para comprender completamente el impacto de esta nueva era tecnológica proporcionada por la IA en la salud.

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Objetivos: analisar se a Recomendação Geral n.º24, sobre saúde da mulher, amplia ou constrói interpretações para os Estados Partes da Convenção para a Eliminação de todas as Formas de Discriminação contra a Mulher. Metodologia: foi realizada uma pesquisa documental e bibliográfica para coletar dados e revisar criticamente documentos internacionais e literatura especializada. Os resultados foram analisados por meio da revisão crítico-narrativa. Resultados: a Convenção abrange direitos da mulher, incluindo saúde, e o Comitê da Convenção sobre a eliminação de todas as formas de discriminação contra as mulheres emite recomendações gerais para orientar sua implementação pelos Estados Partes. A Recomendação Geraln.º24 amplia as recomendações originais, abordando questões como saúde sexual, violência de gênero e participação na tomada de decisões. Conclusões: a interpretação política da Convenção, conforme preconizado por Kelsen, permite observar as necessidades e o contexto político dos Estados-parte. A Recomendação Geraln.º24 amplia as recomendações, refletindo a necessidade de adaptação das políticas públicas às mudanças globais e às necessidades das mulheres.

Objectives: This study examines whether General Recommendation (GR) No. 24, on women's health, broadens or constructs interpretations for the State parties of the Convention on the Elimination of All Forms of Discrimination against Women. Methodology: A documentary and bibliographical research was conducted to collect data and critically review international documents and specialized literature. The results were analyzed through critical-narrative review. Results: The Convention covers women's rights, including health, and the Committee on the Elimination of Discrimination against Women issues general recommendations to guide its implementation by State parties. GR No. 24 expands the original recommendations, addressing issues such as sexual health, gender-based violence, and participation in decision-making. Conclusions: The political interpretation of the Convention, as advocated by Kelsen, enables the observation of the needs and political context of the State parties. GR No. 24 expands the recommendations, reflecting the need to adapt public policies to global changes and women's needs.

Objetivos: Este estudio analiza si la Recomendación General (RG) n. 24, sobre la salud de la mujer, amplía o construye interpretaciones para los Estados Partes de la Convención para la Eliminación de todas las Formas de Discriminación contra la Mujer. Metodología: Se realizó una investigación documental y bibliográfica para recopilar datos y revisar críticamente documentos internacionales y literatura especializada. Los resultados fueron analizados mediante la revisión crítico-narrativa. Resultados: La Convención abarca los derechos de las mujeres, incluida la salud, y el Comité de la Convención sobre la eliminación de todas las formas de discriminación contra la mujer emite recomendaciones generales para guiar su implementación por parte de los Estados-partes. La RG n. 24 amplía las recomendaciones originales, abordando cuestiones como la salud sexual, la violencia de género y la participación en la toma de decisiones. Conclusiones: La interpretación política de la Convención, como preconiza Kelsen, permite la observación de las necesidades y el contexto político de los Estados Partes. La RG n. 24 amplía las recomendaciones, reflejando la necesidad de adaptar las políticas públicas a los cambios globales y a las necesidades de las mujeres.

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Introduction: Surgical campaigns for thyroid surgery in low-income environments are very efficient, but there is little literature reporting results. These campaigns are complex due to multiple particularities: highly evolved cases, the need for professionals to travel or an obvious socio-cultural barrier influence towards the surgical act. We describe a surgical campaign in Cameroon to treat patients with goiter and issue some medical and sociocultural recommendations in view of our experience for its implementation with guarantees. Material and methods: An experienced group carried out an 11-day campaign at the Saint Martin de Porres Dominican Hospital, Yaounde, Cameroon. Demographic data, TSH values, surgery and complications after a 12-month follow-up were analyzed. Results: Thirty-eight patients with goiter were selected for the campaign and 32 patients (mean age, 40-years-old; 30 females) were operated. Bilateral goiter, as assessed with echography, was diagnosed in 13 patients (41%). Ten patients (31%) had a WHO grade II goiter (visible with the neck in a normal position). The surgical procedures were 18 unilateral thyroidectomy with isthmectomie, 13 total thyroidectomy, and 1 totalizing thyroidectomy, due to previous unilateral thyroidectomy (cancer recurrence). A pathological study in 13 patients (40%, extra cost 60 €) showed benign multinodular goiter/thyroid nodule (12 patients) and an extensive papillary carcinoma (one patient). Six months postoperatively, 3 patients had a slight dysphonia and one patient had persistent hypocalcemia. Follow-up was completed in all patients, either face to face (75%, 24 patients) or by phone (25%, 8 patients who failed to have a TSH test because of its cost, 23 €). Conclusions: Surgical campaigns to treat thyroid pathology can be carried out with guarantees if a series of important steps are followed: active participation of the patient's environment, thyroid ultrasound by the surgical team to decide which technique, intense awareness about monitoring and hormone replacement therapy, and the participation of local personnel for long-term follow-up.

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Introduction: The Male Warrior Hypothesis (MWH) proposes that sex-specific selective pressures have promoted male cooperation with the ingroup members to outcompete rival groups. However, intergroup conflicts do not occur in isolation and the outcomes of previous competitions may influence group cooperativeness. Since this phenomenon is not well understood, we aimed to shed light on the effect of previous competition outcome on later cooperative behavior under intergroup conflicts. Based on the MWH, we hypothesized that repeated contests between groups could enhance ingroup cooperation, regardless of the outcome of the previous contest because status is at risk, but when competition is not present, participants would move to the symmetric equilibria. Methods: To test this hypothesis, we recruited 246 individuals organized in groups of 6 and measured cooperation using a threshold public good game over two rounds, manipulating the outcome in the first round to create groups of winners and losers. Results: Our results show that intergroup conflict scenarios promoted cooperation in both victory and defeat conditions, whereas, in the control scenario only losers increased their cooperation. Discussion: We argue that winners under the presence of an external threat may enhance in-group cooperation in order to assure their status; whereas, losers may be attempting to regain it.

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Infanticide and adoption have been attributed to sexual selection, where an individual later reproduces with the parent whose offspring it killed or adopted. While sexually selected infanticide is well known, evidence for sexually selected adoption is anecdotal. We report on both behaviors at 346 nests over 27 y in green-rumped parrotlets (Forpus passerinus) in Venezuela. Parrotlets are monogamous with long-term pair bonds, exhibit a strongly male-biased adult sex ratio, and nest in cavities that are in short supply, creating intense competition for nest sites and mates. Infanticide attacks occurred at 256 nests in two distinct contexts: 1) Attacks were primarily committed by nonbreeding pairs (69%) attempting to evict parents from the cavity. Infanticide attacks per nest were positively correlated with population size and evicting pairs never adopted abandoned offspring. Competition for limited nest sites was a primary cause of eviction-driven infanticide, and 2) attacks occurred less frequently at nests where one mate died (31%), was perpetrated primarily by stepparents of both sexes, and was independent of population size. Thus, within a single species and mating system, infanticide occurred in multiple contexts due to multiple drivers. Nevertheless, 48% of stepparents of both sexes adopted offspring, and another 23% of stepfathers exhibited both infanticide and long-term care. Stepfathers were often young males who subsequently nested with widows, reaching earlier ages of first breeding than competitors and demonstrating sexually selected adoption. Adoption and infanticide conferred similar fitness benefits to stepfathers and appeared to be equivalent strategies driven by limited breeding opportunities, male-biased sex ratios, and long-term monogamy.

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Major depressive disorder (MDD) seriously threatens human health. BRICS, known as an acronym for "Brazil, Russia, India, China, and South Africa," were also actively carrying out researches on MDD. This study aimed to conduct a bibliometric study of research on MDD conducted by the BRICS. By searching in the Web of Science and using the software Vosviewer and Citespace as analysis tools, this study analyzed the cooperation network at the country, institution, author-specific levels, the research hotspots and trends from BRICS between 2003-2022. A total of 10,911 articles were finally included. Our findings showed that researches on MDD from BRICS rapidly increased during the past two decades. China and India have shown explosive growth, while South Africa has the largest average "Usage Count" and "Time Cited". The current cooperation partners of the BRICS were mainly high-income countries and other developing countries with similar cultures, languages, and geographical locations. Institutions in high-income countries served as the main bridges for BRICS cooperation, while at the author level, some core authors in the BRICS countries serve as centers. China showed a flexible model in domestic partnership, but institutions and authors in the other four countries have gathered to cooperate within the group. BRICS research on MDD mainly focused on cognitive science, brain science, epidemiology, and disease mechanisms. The keywords"gut microbiota", "network analysis," "machine learning" and "sleep quality" showed explosive growth and might become research hotspots in the near future. This bibliometric analysis provided a science knowledge graph and references for other researchers.

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Understanding the evolution of cooperation is a major question in Evolutionary Biology. Here, we extend a previously proposed mathematical model in Evolutionary Game Theory that investigated how resource use by a single species composed of cooperators and defectors may lead to its maintenance or extinction. We include another species in the model, so as to investigate how different intra and interspecific interactions of cooperative or competitive nature among individuals that share the same essential resource may drive the survival and evolution of the species. Several outcomes emerge from the model, depending on the configuration of the payoff matrix, the individual contribution to the resource pool, the competition intensity between species, and the initial conditions of the system dynamics. Observed results include scenarios in which species thrive due to the action of cooperators, but also scenarios in which both species collapse due to lack of cooperation and, consequently, of resources. In particular, a high initial availability of resources may be the determinant factor to the survival of both species. Interestingly, cooperation may be more favored when individuals have less incentive to cooperate with others, and the survival of their populations may depend crucially on their competitive capacities.

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Resumo Este trabalho analisa as ações e parcerias estabelecidas entre os integrantes das Secretarias Estaduais de Saúde e da Assistência Social do Rio de Janeiro e outras organizações da área da saúde e assistência para atender à emergência sanitária desencadeada pela síndrome congênita do vírus Zika entre os anos de 2015 e 2018. O contexto caracterizava-se por acentuada crise econômica, erosão da capacidade de governança das autoridades políticas no estado, e reduzido conhecimento técnico-científico sobre a epidemia. Além de análise de documentos relativos ao tema, foram feitas 17 entrevistas com gestores e profissionais das duas secretarias. Roteiros semiestruturados focalizaram ações intersetoriais e processos de cooperação e coordenação inter e intraorganizacional. A grade analítica contemplou aspectos dos papéis interpessoais, informacionais e de tomada de decisão dos gestores e técnicos. Os resultados mostram que, apesar da crise política e econômica, os atores das secretarias conseguiram criar um fluxo de atenção aos pacientes. Observou-se que mecanismos informais de cooperação e coordenação foram fundamentais para a criação de estratégias intersetoriais de longo prazo.

Abstract This paper focuses on the actions and partnerships established between members of the State Secretariats of Health and Social Assistance in Rio de Janeiro and other organizations in the health and assistance areas to respond to the health emergency triggered by the congenital Zika virus syndrome between 2015 and 2018. Some characteristics of the context were: a severe economic crisis, the erosion of the governance capacities of the state political authorities as well and scarce technical-scientific knowledge about the epidemic. The study was grounded on an analysis of documents related to the topic, 17 semi-structured interviews with managers and professionals from the two secretariats. Interview scripts focused on intersectoral actions and processes of cooperation and coordination within and between organizations. The analytical grid included aspects of the interpersonal, informational, and decision-making roles of managers and technicians. The results show that, despite the political and economic crisis, the Secretariat actors managed to create a flow of care for patients. Informal cooperation and coordination mechanisms were crucial for the creation of long-term intersectoral strategies.