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Women with deep infiltrating endometriosis (DIE) can benefit from the use of progestins. Our aim is to explore if levonorgestrel-releasing intrauterine system (LNG-IUS) non inferior to dienogest (DNG) in improving deep endometriosis women's quality of life (QoL). This randomized open-label clinical trial included forty women with DIE assessed using clinical history and physical examination, transvaginal ultrasonography and magnetic resonance of the pelvis without any previous surgical treatment, with two treatments arms. The two groups underwent a 3-month washout of hormonal treatments, and then received either DNG or LNG-IUS for 6 months. QoL was assessed prior to and 6 months after the intervention, using the SF36 and the EHP30. DNG and LNG-IUS showed an increase on all domains of the SF36 (p < .001). There was no difference between treatments on the improvement observed (p > .05 for all domains). DNG and LNG-IUS, also, showed improvement on all domains of EHP30 (p < .001), except "relationship with children" and "feelings about pregnancy." However, there was no statistical difference between treatments for all sections scores (p > .05). The treatment of deep endometriosis symptoms using either DNG or LNG-IUS in women with no prior surgical treatment is associated with improvement in QoL.Trial Registration Number: This trial is registered on "The Brazilian Registry of Clinical Trials (ReBECID: RBR-8fjx2jp)," that is part of Primary Registries in the WHO Registry Network, under the title: "Dienogest versus Levonorgestrel IUS on deep endometriosis patient´s QoL without surgery" on June 14, 2021; https://ensaiosclinicos.gov.br/rg/RBR-8fjx2jp.

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OBJECTIVES: to verify the contribution of mothers' oral health impact profile to their children's oral health profile and the contribution of mothers' well-being and the caries index (dmft) to children's well-being. METHODS: This is a cross-sectional observational study. Mothers and pre-school children enrolled in public schools in the municipality of Araraquara-SP took part. The Oral Health Impact Profile Questionnaire (OHIP-14), Satisfaction with Life Scale (SWLS), Early Childhood Oral Health Impact Scale (ECOHIS) and the Autoquestionnaire Qualité de Vie Enfant Imagé (AUQEI) were used. To diagnose caries, a clinical examination was carried out to calculate the dmft index. Path analysis was carried out and the path coefficients were estimated (ß) and evaluated using the z-test (α = 5%). RESULTS: 443 children took part (5.19 ± 0.64 years; 52.4% boys) with an mean dmft of 1.31 ± 2.19. The mean age of the mothers was 33.4 ± 7.01 years. There was a significant impact of dmft and maternal well-being on the child's subjective well-being (s2explained = 43%). The mothers' oral health impact profile and the child's caries experience had a significant influence on both the child (OHIP: ß = 0.22; p < 0.001; dmft: ß = 0.48; p < 0.001) and the family (OHIP: ß = 0.29; p < 0.001; dmft: ß = 0.32; p < 0.001). The child's dmft (ß=-0.10; p = 0.005) and the mothers' subjective well-being (ß=-0.61; p < 0.001) had a significant impact on the child's subjective well-being. CONCLUSION: The mothers' oral health impact profile and the child's caries experience had an impact on both the child and the family. Mothers' subjective well-being and caries experience should be considered when assessing the subjective well-being of Brazilian preschool children.

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RESUMO Objetivo caracterizar o grau de intensidade e desconforto do zumbido de indivíduos, pós-COVID-19. Métodos pesquisa observacional, exploratória e de corte transversal com 242 participantes, divididos em dois grupos iguais, pareados de acordo com gênero e faixa etária: grupo-controle (GC), composto por indivíduos com zumbido em período pré-pandêmico, e grupo de estudo (GE), composto por participantes que referiram zumbido pós-COVID-19, de diferentes regiões do país. Foram comparados os escores gerais e de domínios específicos do Tinnitus Handicap Inventory (THI) e da Escala Visual Analógica (EVA), por meio de análise estatística descritiva, testes de normalidade, comparação de grupos e de correlação entre as variáveis. Resultados em cada grupo, 93 participantes eram do gênero feminino e 28, do masculino, sendo a média das idades de 35 anos. Os graus desprezível e leve do THI e leve e moderado da EVA foram maiores para o GE, enquanto o domínio catastrófico do THI e a EVA apontaram piores escores para o GC. Houve diferença significativa entre todos os domínios das escalas inter e intragrupos. Conclusão manifestações mais brandas de incômodo, intensidade e desconforto do zumbido pós-COVID-19 foram encontradas, em comparação ao sintoma decorrente de outras causas. Assim, o impacto do zumbido para a população estudada foi menos autorreferido, apontando para melhores possibilidades terapêuticas e prognósticas.

ABSTRACT Purpose to characterize the degree of intensity and discomfort of tinnitus in post-COVID-19 individuals. Methods observational, exploratory and cross-sectional research with 242 participants, divided into two equal groups matched according to sex and age group. The control group, composed of individuals with tinnitus in the pre-pandemic period, and the study group, composed of participants who reported post-COVID-19 tinnitus in different regions of the country. General and domain-specific scores from the Tinnitus Handicap Inventory (THI) and Visual Analogue Scale (VAS) were compared through descriptive statistical analysis, normality tests, comparison of groups and correlation between variables. Results in each group, 93 participants were female and 28 male, with a mean age of 35 years. The "negligible" and "mild" degrees of the THI and the "mild" and "moderate" of the VAS were higher for the SG, while the catastrophic domain of the THI and the VAS indicate worse scores for the CG. There was a significant difference between all domains of the inter- and intra-group scales. Conclusion milder manifestations of post-COVID-19 tinnitus disturbance, intensity and discomfort were found, compared to symptoms arising from other causes. Thus, the self-reported impact of the studied population was lower, pointing to better therapeutic and prognostic possibilities.

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INTRODUÇÃO: As alterações impostas pela doença renal e por seu tratamento interferem negativamente na qualidade de vida dos indivíduos com doença renal crônica. A atividade física é relatada como uma alternativa terapêutica nesta população, porém a maioria dos pacientes submetidos à hemodiálise apresentam baixos níveis de atividade física. OBJETIVO: verificar a correlação entre a atividade física e qualidade de vida em indivíduos com doença renal crônica em hemodiálise. MÉTODOS: Este estudo é observacional, analítico, descritivo e quantitativo, desenvolvido em uma das Unidades de Hemodiálise da região Noroeste do Rio Grande do Sul, Brasil, na atenção clínica terciária, durante o período de novembro de 2018 a fevereiro de 2019. Foram incluídos indivíduos maiores de 18 anos e em tratamento hemodialítico por doença renal crônica há mais de três meses, pertencentes ao serviço de hemodiálise. Os critérios de exclusão foram os indivíduos com diagnóstico de doença renal aguda; aqueles que apresentaram aparentemente dificuldades em compreender, responder ou que não realizaram completamente os instrumentos de avaliação propostos (qualidade de vida e pedômetros), indivíduos que no momento da avaliação não apresentaram condições clínicas estáveis. A coleta de dados foi realizada pela análise dos prontuários clínicos e eletrônicos e entrevista semiestruturada. Utilizou-se avaliação pelos pedômetros e pelo questionário Kidney Disease and Quality of Life Short-Form-KDQOL-SFTM. Análises de modelagem por regressão foram realizadas para testar a associação entre o número de passos/dia e os desfechos avaliados RESULTADOS: Foram incluídos na amostra 40 pacientes, destes, 70% são homens, com média de idade de 59,9 ± 13,0 anos. Na correlação entre atividade física e qualidade de vida, o número de passos/dia teve correlação significativa com as dimensões sintomas e problemas (r=0,523;p=0,003), efeitos da doença (r=0,458; p=0,010), função sexual (r=0,361;p=0,050), sono (r=0,357;p=0,049), função física (r=0,617;p=<0,001), papel físico (r=0,504;p=0,004), dor (r=0,496; p=0,005), bem estar emocional (r=0,407; p=0,023), papel emocional (r=0,435;p=0,014), função social (r=0,522;p=0,003), energia/fadiga (r=0,436;p=0,014) e composição física (r=0,598;p=<0,001). As variáveis idade, índice de massa corporal, tempo de hemodiálise e sexo não apresentaram correlação com o número de passos/dia. CONCLUSÃO: Houve correlação positiva entre atividade física e qualidade de vida, ou seja, quanto maior a média de número de passos/dia melhor a qualidade de vida de indivíduos em hemodiálise.

INTRODUCTION: The changes imposed by kidney disease and its treatment negatively affect the quality of life of individuals with kidney disease. Physical activity is reported as a therapeutic alternative in this population; however, most patients undergoing hemodialysis have low levels of physical activity. OBJECTIVE: To verify the correlation between physical activity and quality of life in individuals with chronic kidney disease undergoing hemodialysis. METHODS: This study is observational, analytical, descriptive, and quantitative developed in one of the Hemodialysis Units in the Northwest region of Rio Grande do Sul, Brazil, in tertiary clinical care, during the period from November 2018 to February 2019. Individuals over 18 years old and undergoing hemodialysis for chronic kidney disease for more than three months; belonging to the hemodialysis service. Data collection was performed by analyzing clinical and electronic medical records and semi-structured interviews. Evaluation using pedometers and the Kidney Disease and Quality of Life Short FormKDQOL-SFTM questionnaire was used. Regression modeling analyzes were performed to test the association between the number of steps/ day and the evaluated outcomes. RESULTS: 40 (Forty) patients were included in the sample, of which 70% are men, with a mean age of 59.9 ± 13.0 years. In the correlation between physical activity and quality of life, the number of steps / day had a significant correlation with the dimensions symptoms and problems (r=0,523;p=0,003), effects of the disease (r=0,458; p=0,010), sexual function (r=0,361;p=0,050), sleep (r=0,357;p=0,049), physical function (r=0,617;p=<0,001), physical role (r=0,504;p=0,004), pain (r=0,496; p=0,005), emotional well-being (r=0,407; p=0,023), emotional role (r=0,435;p=0,014), social function (r=0,522;p=0,003), energy / fatigue (r=0,436;p=0,014) and physical composition (r=0,598;p=<0,001). The sample profile variables did not correlate with the number of steps/day. CONCLUSION: There was a positive correlation between physical activity and quality of life; that is, the higher the average number of steps/day, the better the quality of life of individuals undergoing hemodialysis.

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O tratamento do câncer de cabeça e pescoço (CCP) é multimodal e pode gerar diferentes comprometimentos físicos e psicológicos. O objetivo do estudo foi avaliar o perfil da qualidade de vida dos pacientes com CCP, em busca de possíveis alvos terapêuticos que possam ser reabilitados. Trata-se de um estudo descritivo do tipo observacional transversal, desenvolvido em um Centro de Assistência de Alta Complexidade em Oncologia. Os dados foram coletados através da anamnese e do questionário de qualidade de vida da University of Washington (UW-QOL). A amostra foi composta por 68 pacientes com câncer de cabeça pescoço que realizaram radioterapia adjuvante há no mínimo 90 dias. Houve predomínio do sexo masculino (89%) e acometimento da orofaringe (69%). Além da radioterapia, 53% dos indivíduos também realizaram cirurgia e 65% quimioterapia. As funções estomatognáticas foram as mais afetadas, seguido por implicações negativas relacionadas às atividades de vida diária e de aspectos de ordem psicológica. De acordo com a natureza dos domínios apurados no questionário de vida UW-QOL, a baixa pontuação observada nas questões referentes à atividade de vida diária e nos componentes de avaliação do estado psicológico, é pertinente supor que as complicações tardias impostas tanto pela fisiopatologia do CCP quanto pelo tratamento antineoplásico devam ser abordadas por uma equipe multidisciplinar alinhados no objetivo sinérgico de reabilitar as funções estomatognáticas, a alimentação e a capacidade física. Embora nossos dados não sugiram comprometimentos emocionais, o apoio adicional do psicólogo, poderia ser cogitado com o objetivo de fortalecer e motivar o engajamento na reabilitação do complexo quadro clínico intrínseco ao CCP.

The treatment of head and neck cancer (HNC) is multimodal and can generate different physical and psychological impairments. The aim of this study was to assess the quality of life profile of patients with HNC, in search of possible therapeutic targets that can be improved. This is a descriptive, cross-sectional, observational study, developed at a High Complexity Care Center in Oncology. Data were collected through anamnesis and the University of Washington quality of life questionnaire (UW-QOL). The sample consisted of 68 patients with head and neck cancer who underwent adjuvant radiotherapy for at least 90 days. There was a predominance of males (89%) and an involvement of the oropharynx (69%). In addition to radiation therapy, 53% of individuals also underwent surgery and 65% chemotherapy. Stomatognathic functions were the most affected, followed by negative implications related to activities of daily living and psychological aspects. According to the nature of the domains found in the UW-QOL Questionnaire, the low scores observed in the questions related to the activities of daily living and in the components of the psychological status assessment, it is pertinent to assume that the late complications imposed by both the pathophysiology of the HNC as well as the antineoplastic treatment should be approached by a multidisciplinary team aligned with the synergistic objective of rehabilitating stomatognathic functions, nutrition, and physical capacity. Although our data do not suggest emotional impairments, additional support from a psychologist could be considered in order to strengthen and motivate engagement in the rehabilitation of the complex clinical condition intrinsic to HNC.

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RESUMO Objetivo: avaliar qualidade de vida, experiências espirituais em pacientes com câncer e sua correlação. Método: estudo transversal, realizado na Emergência, de fevereiro a setembro de 2017. Utilizado o Medical Outcome Study 36 - Item Short-Form Health Survey para verificação da qualidade de vida, com oito dimensões, escore de 0 (pior estado) a 100 (melhor estado) e a Escala Diária de Experiência Espiritual, com 16 itens, pontuação entre 16 e 94 (menores pontuações refletem maior frequência de experiências). Utilizou-se o Coeficiente de Spearman para correlacionar qualidade de vida e espiritualidade. Resultados: 83 pacientes, média de idade 58 anos, predomínio masculino. A dimensão da qualidade de vida mais comprometida foi "aspecto físico". A Escala de Experiência Espiritual apresentou média 51, com correlação negativa entre qualidade de vida e espiritualidade. Conclusão: a espiritualidade relaciona-se com qualidade de vida e deve ser considerada no atendimento a pacientes com câncer na emergência.

RESUMEN: Objetivo: evaluar la correlación entre la calidad de vida y las experiencias espirituales en pacientes con cáncer. Método: estudio transversal, realizado en el Departamento de Emergencias, de febrero a septiembre de 2017. Par verificar la calidad de vida se utilizó el Medical Outcome Study 36 - Item Short-Form Health Survey, con ocho dimensiones, puntaje de 0 (peor estado) a 100 (mejor estado) y la Escala Diaria de Experiencia Espiritual, con 16 ítems, puntajes entre 16 y 94 (los puntajes más bajos reflejan una mayor frecuencia de experiencias). El coeficiente de Spearman se utilizó para correlacionar la calidad de vida y la espiritualidad. Resultados: el estudio se realizó con 83 pacientes, edad promedio 58 años, predominantemente hombres. La dimensión de calidad de vida más comprometida fue el "aspecto físico". La escala de experiencia espiritual mostró un promedio de 51, con una correlación negativa entre calidad de vida y espiritualidad. Conclusión: la espiritualidad está relacionada con la calidad de vida y debe considerarse en la atención de pacientes con cáncer en la sala de emergencias.

ABSTRACT Objective: Evaluate the quality of life, spiritual experiences in cancer patients and their correlation. Method: Cross-sectional study, carried out in the Emergency, from February to September 2017. Using the Medical Outcome Study 36 - Item Short-Form Health Survey for quality of life verification, with eight dimensions, the scores from 0 (worst condition) to 100 (best condition) and the Daily Scale of Spiritual Experience, with 16 items, scoring between 16 and 94 (lower scores reflect higher frequency of experience). The Spearman coefficient was used to correlate quality of life and spirituality. Results: 83 patients, mean age 58 years, male predominance. The most compromised quality of life's dimension of was "physical aspect". The Spiritual Experience Scale presented a mean of 51, with a negative correlation between the quality of life and spirituality. Conclusion: Spirituality is related to quality of life and should be considered in the care of cancer patients in the emergency.

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ABSTRACT Objective To evaluate the impact of oral health on quality of life and to examine the association with sociodemographic, clinical staging and dental variables in women diagnosed with breast cancer. Methods This is an observational cross-sectional study with sample composed of 89 women treated at a Reference Hospital in Vitória, Espírito Santo, Brazil, between January and December 2012. Two scripts in the form of interviews were used, one to record participants' information; and the Oral Health Impact Profile (OHIP-14), to evaluate the impacts produced by the oral condition on quality of life. Descriptive analysis of data was performed. The comparison of the percentage of the impact dimensions with independent variables was tested by the chi-square test or the Fisher exact test, when appropriate. To assess the strength of association between exposure and event, odds ratio was calculated. Significance level of 5% was adopted. Results The impact was 28.1%, there was a statistically significant association with variables income (p = 0.039) and reason for the visit to the oral health professional (p = 0.012). Conclusion Studies on quality of life of cancer patients are of fundamental importance for understanding the impact of oral health problems on quality of life.

RESUMO Objetivo Avaliar o impacto produzido por problemas bucais na qualidade de vida; e examinar a associação com as variáveis sociodemográficas, odontológicas e de estadiamento clínico em mulheres com diagnóstico de câncer de mama. Métodos Estudo observacional transversal. Amostra composta por 89 mulheres atendidas em um hospital de referência em Vitória, Espírito Santo, Brasil, entre janeiro e dezembro de 2012. Utilizaram-se dois roteiros na forma de entrevista, um para registro das informações das participantes; e o Oral Health Impact Profile (OHIP-14), para avaliar os impactos produzidos pela condição bucal sobre a qualidade de vida. Realizou-se análise descritiva dos dados. A comparação dos percentuais das dimensões do impacto com as variáveis independentes foi verificada pelo teste qui-quadrado ou pelo teste exato de Fisher, quando apropriado. Para avaliar a força da associação entre evento e exposição, calculou-se o odds ratio. Adotou-se o nível de significância de 5%. Resultados O impacto foi de 28,1%, houve associação estatisticamente significante com as variáveis renda (p=0,039) e motivo da visita ao profissional de saúde bucal (p=0,012). Conclusão Estudos sobre qualidade de vida em pacientes oncológicos são de fundamental importância na compreensão do impacto dos problemas bucais em sua vida.

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Abstract Aim: To assess the prevalence, quality of life (QoL), and the damages caused by PH, in the professional and personal scope of Physical Education academics with Primary Hyperhidrosis (PH). Methods: A descriptive, exploratory, qualitative and quantitative cross-sectional study was carried out. Twenty-five students from the physical education course at Tiradentes University, Aracaju-SE, were interviewed from August to November 2017. Validated questionnaires were used on PH's influence in academic activities and QoL. absolute and relative frequencies in the case of categorical variables and measures of trend and central variability in the case of numerical variables. Results: The prevalence of PH in students of Physical Education was 11.11%, mainly in combined sites, such as palmoplantar, and with no difference between the sexes. The symptoms started mostly during childhood and adolescence. Most of the interviewees (92%) reported difficulties with activities such as sports, use of personal protective equipment, handling of work equipment and instruments, and exacerbation in stress situations. They reported significant harm to QoL in situations of greeting people with handshakes, writing, wearing socks and dancing socially. Conclusion: Although PH is a disease that negatively impacts the QoL, it is still little known in the academic world with little demand for medical help. Therefore, it is necessary greater dissemination of the disease for its early diagnosis, related to the intensity of the sweating for a better therapeutic approach.

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Objective: To evaluate the impact on quality of life caused by oral health problems among administrative sector employees of a mixed-economy company, residents in Vitória, Brazil. Material and Methods: This cross-sectional study used a random sample of 167 individuals. Quality of life measured by the subjective indicator OHIP-14, was the outcome considered; independent variables were sociodemographic, oral health dental services use and perceived prosthesis need. OHIP evaluates impairments in the three dimensions of social, psychological and physical functional conditions. To evaluate differences between groups, Chi-Square and Fisher's Exact Tests were used (p<0.05). To assess the strength of association, Odds-Ratio was calculated. Results: The health professional most sought by individuals in the last 12 months was the dentist (88.5%), agreed by the company (62.6%) due to prevention reasons (62.6%). The prevalence of impact caused by oral health problems was 7.8% and most recorded dimensions were physical pain (6%) and psychological discomfort (5.4%). Impact perception was greater among individuals who declared need for partial removable denture at functional limitation and psychological incapacity dimensions. Subjects that used urgency oral health services presented more impact at psychological discomfort dimension. Conclusion: The impact frequency was low. Objective and subjective measures can provide accurate analysis to support health policies directed to the real population needs.

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Objective: To evaluate the impact of oral problems on the quality of life of women before and during chemotherapy for breast cancer. Material and Methods: A longitudinal study was conducted on women with breast cancer at a Hospital reference, Espírito Santo, Brazil from January 2012 to January 2013. Assessment was performed at three time-points, the first before the onset of therapeutic intervention, the second after the first chemotherapy session, and the third after the second chemotherapy session. The volunteers were assessed using interviews that included the application of the subjective indicator Oral Health Impact Profile (OHIP-14). The data were subjected to descriptive analysis based on tables of absolute and percentage frequencies relative to the OHIP-14 dimensions. McNemar's test assessed the direction of discordance, and the Kappa test measured the levels of concordance among the three assessments. The significance level was established at 5%. Results: The percent frequency of the impact of oral problems on the quality of life increased from the first (27%) to the second (49%) time-point, and functional limitation (p=0.001), physical pain (p=0.039), and physical disability (p=0.039) were statistically significant. Conclusion: Oral problems exerted a substantial impact on the volunteers' quality of life before the onset of chemotherapy, and quality of life became poorer after the onset of treatment. Patients with breast cancer require specific oral care and should be monitored before, during, and after anticancer treatment to minimize the deleterious effects of chemotherapy and improve their quality of life.

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