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Acetabular protrusion (AP) is present in 33 to 55% of patients with osteogenesis imperfecta (OI). Even though the finding is relatively common, it is poorly described in pediatric patients. The objective of this study was to describe the incidence and associations of AP in pediatric OI patients. We retrospectively and cross-sectionally evaluated clinical histories and radiographic findings of OI patients aged 2 to 19.5 years, recording sex, age, severity, anthropometric measurements, ambulation status, femoral fractures history, and occurrence of orthopaedic surgeries and nephropathy. AP was considered present when the center-edge (CE) angle was more than 35 degrees and the acetabular line crossed the Kohler's line by more than 1 and 3 mm in boys and girls, respectively, and 3 and 6 mm in adult males and females, respectively. The association with risk factors and complications was analyzed through univariate and multivariate logistic regression. A total of 71 children were evaluated. The median age was 8.6 years, and 54.9% of them had moderate to severe forms of OI. In 71.8% of the children, an abnormal CE angle was found, being frequent in mild, moderate, and severe cases. AP was present in 22.5% of all patients and in 41% of children with moderate to severe OI, and was significantly associated with older ages ( p = 0.0062) and nonwalking status ( p = 0.0093). We found a high prevalence of AP in children with moderate to severe forms of OI, which was present even at younger ages. In addition, we found a significant increase in the number of children with abnormal CE angles even in those with mild forms of OI. The presence of AP was associated with the severity of the OI and age, and in a negative association with the ambulatory status.

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Abstract The safflower crop is considered a great alternative for crop rotation since drought tolerance and low production cost are attractive for its choice. However, safflower seeds show dormancy soon after dispersal from the mother plant, making it difficult to successfully establish plants using newly harvested seeds. The influence of temperature, gibberellin and light/dark on dormancy break of safflower seeds during storage were investigated. In a completely randomized design, freshly harvested seeds or stored for 100 and 200 days (paper bag, 20 °C/ 60% UR) were treated with GA3 (0 and 100 µM), at 4, 10 and 25 °C, in the presence and absence of light, during the germination test. Seeds were evaluated for germination percentage, germination speed and seedling survival after 21 days. The temperature of 10 °C, in combination with GA3 (0/100 µM), or light/dark, provided the highest seed germination results, for freshly-harvested seeds and stored seeds. Collectively, these observations indicate that dormancy was not affected by gibberellic acid (100 µM GA3) and the germination results at 21 days were significantly higher, in relation to the use of GA3, under light or dark. Recently harvested seeds could efficiently germinate at 10 °C in the dark, while seeds dry-stored at 20 °C had decreased germination percentages.

Resumo A cultura do cártamo é considerada uma ótima alternativa para a rotação de culturas na segunda safra, uma vez que a tolerância à seca e o baixo custo de produção são atrativos para sua escolha. Entretanto, as sementes de cártamo apresentam dormência logo após a dispersão da planta-mãe, dificultando o êxito do estabelecimento de plantas com a utilização de sementes recém-colhidas. A influência da temperatura, giberelina e luz/escuro na superação de dormência de sementes de cártamo durante o armazenamento foram investigados. Em um delineamento inteiramente casualizado, as sementes recém-colhidas ou armazenadas durante 100 e 200 dias (em saco de papel, 15 °C/ 60% UR) foram submetidas às doses de GA3 (0 e 100 µM), às temperaturas de 4, 10 e 25 °C, na presença e ausência de luz, durante o teste de germinação. As sementes foram avaliadas quanto à germinação, velocidade de germinação e sobrevivência das plântulas após 21 dias. A temperatura de 10 °C, em combinação com o uso de GA3 (0/100 µM), ou luz/escuro, proporcionou os maiores resultados de germinação de sementes em relação às demais temperaturas, para as sementes recém-colhidas e armazenadas. Coletivamente, essas observações indicam que a dormência não foi afetada pelo ácido giberélico (100 µM GA3) e os resultados de germinação aos 21 dias foram significativamente maiores, em relação ao uso de GA3, no claro ou no escuro. As sementes recém-colhidas germinam eficientemente na temperatura de 10 °C no escuro, enquanto as sementes armazenadas a 20 °C apresentaram redução da germinação.

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Abdominal hernias are defects due to loss of continuity of the fasciae and/or muscles with the protrusion of abdominal structures. They are the third most prevalent and incident abdominal pathology worldwide and the second pathology of consultation in general surgery in patients of age limits. There are various factors that contribute to their formation, but within the scientific community there are various types of classifications, which differ according to the professional training school and their decision-making. This bibliographic review aims to expose the most used abdominal hernia classification systems such as the European one that has a morphological vision, the Ventral Hernia Working Group that proposes its aspect on recurrence together with the modified one that exposes comorbidity and the staging system of ventral hernia that provides a comprehensive approach to classification and management. In addition to the most common complications of the same.

Las hernias abdominales son defectos por pérdida de continuidad de las fascias y/o músculos con la protrusión de estructuras abdominales. Son la tercera patología abdominal más prevalente e incidente a nivel mundial y la segunda patología de consulta en cirugía general en pacientes en límites de edades. Existen diversos factores que contribuyen a su formación, pero dentro de la comunidad científica existe diversos tipos de clasificaciones, las cuales difieren de acuerdo a la escuela de formación de los profesionales y su toma de decisiones. La presente revisión bibliográfica pretende exponer los sistemas de clasificación de hernias abdominales más utilizados como la Europea que tiene una visión morfológica, el Grupo de Trabajo de Hernia Ventral que propone su aspecto sobre la recurrencia junto con el modificado que expone comorbilidad y el sistema de estadificación de hernia ventral que brinda un enfoque integral para clasificación y manejo. Además de las complicaciones más habituales de las mismas.

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Hypertrophic feline muscular dystrophy (HFMD), rarely reported in the literature, is a disease caused by a hereditary recessive dystrophin deficiency linked to the X chromosome, mainly affecting young male cats. Here, we presented the clinical aspects, food management, and clinical evolution of a seven-year-old mixed-breed cat diagnosed with HFMD, having a primary history of progressive tongue protrusion.

A distrofia muscular hipertrófica felina é uma doença causada por uma deficiência da distrofina com caráter hereditário recessivo ligado ao cromossomo X, com poucos registros de ocorrência na literatura, que acomete principalmente gatos machos jovens. Neste trabalho, são relatados os aspectos clínicos, manejo alimentar e evolução clínica de um gato, sem raça definida, de sete anos com histórico principal de protrusão progressiva da língua e diagnosticado com distrofia muscular hipertrófica felina.

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SUMMARY: External occipital protuberance (EOP) is a midline bony protrusion in the occipital bone, the significance of which has gained recent attention in the medical community. Our present study aims to assess the average size of EOP in a Jordanian cohort and its relation to age and sex, while determining the frequency of enlarged EOP in this cohort. The present study was a cross-sectional study that was carried out in a referral hospital in Jordan. We reviewed thousands of CT scans taken with dedicated bone window imaging during the last two years, beginning January 2018. Measurements were taken by trained radiology residents and were then further reviewed by radiology specialists. An EOP was classified as enlarged (EEOP) if it exceeded 10 mm. A total of 4409 patients, 2265 (51.4 %) females and 2144 (48.6 %) males, met our inclusion criteria. Their mean age was 54.1 ? 22.2 years. The mean size of the EOP in these patients was 8.4 ? 4.2 mm (range: 0-56 mm). Out of the 4409-study population, 1210 (27.4 %) presented with EEOP. The prevalence of an EEOP was significantly higher in the male population (33.6 %) when compared with the female population (21.6 %) (P < 0.001). The size of the EOP was also significantly related to the age of the patient, with EEOP increasing with increasing age. The mean size of EOP in our Jordanian cohort was 8.4 ? 4.2 mm. The frequency of enlarged EOP was found to be 27.4 % in our cohort, and was significantly more common in males and in older patients.

RESUMEN: La protuberancia occipital externa (POE) es una protuberancia ósea localizada en el plano mediano del hueso occipital, cuya importancia recientemente ha ganado atención en la comunidad médica. Este estudio tuvo como objetivo evaluar el tamaño promedio de POE en una cohorte jordana y su relación con la edad y sexo, mientras se determina la frecuencia de POE aumentada en este grupo. Se llevó a cabo un estudio transversal en un hospital de referencia en Jordania. Revisamos miles de imagenes radiológicas en tomografía computarizada y visualización de ventanas durante los últimos dos años, a partir de enero de 2018. Las mediciones fueron tomadas por residentes de radiología, y luego revisadas por especialistas en radiología. Un POE se clasificó como aumentado (POEA) si superaba los 10 mm. Un total de 4409 pacientes, 2265 (51,4 %) mujeres y 2144 (48,6 %) hombres, cumplieron con nuestros criterios de inclusión. La edad media fue de 54,1 ? 22,2 años. El tamaño medio del POE en estos pacientes fue de 8,4 ? 4,2 mm (rango: 0-56 mm). De la población del estudio 4409, 1210 (27,4 %) presentaron POEA. La prevalencia de una POEA fue significativamente mayor en la población masculina (33,6 %) en comparación con la población femenina (21,6 %) (P <0,001). El tamaño del POE también se relacionó significativamente con la edad del paciente, aumentando el POEA con la edad. El tamaño medio de POE en nuestra cohorte jordana fue de 8,4 ? 4,2 mm. Se encontró que la frecuencia de aumento de POE en nuestra cohorte fue del 27,4 % y fue significativamente más común en hombres y en pacientes mayores.

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BACKGROUND: During embryonic development, complex changes in cell behavior generate the final form of the tissues. Extension of cell protrusions have been described as an important component in this process. Cellular protrusions have been associated with generation of traction, intercellular communication or establishment of signaling gradients. Here, we describe and compare in detail from live imaging data the dynamics of protrusions in the surface ectoderm of chick and mouse embryos. In particular, we explore the differences between cells surrounding the lens placode and other regions of the head. RESULTS: Our results showed that protrusions from the eye region in mouse embryos are longer than those in chick embryos. In addition, protrusions from regions where there are no significant changes in tissue shape are longer and more stable than protrusions that surround the invaginating lens placode. We did not find a clear directionality to the protrusions in any region. Finally, we observed intercellular trafficking of membrane puncta in the protrusions of both embryos in all the regions analyzed. CONCLUSIONS: In summary, the results presented here suggest that the dynamics of these protrusions adapt to their surroundings and possibly contribute to intercellular communication in embryonic cephalic epithelia.

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OBJECTIVE. The purpose of this study was to determine whether the relative length of protrusion of the second metatarsal, measured on MRI and weight-bearing foot radiography, predicts the diagnosis of second metatarsophalangeal (MTP) joint plantar plate (PP) tear on MRI. MATERIALS AND METHODS. We retrospectively evaluated 166 consecutive patients (211 feet). Patients had undergone weight-bearing foot radiography and forefoot MRI. Using the Coughlin method, two independent observers measured second meta-tarsal protrusion length on radiography and MRI. MRI findings were classified as normal PP, complete PP tear, or degenerative or partial PP tear. RESULTS. Patients had a mean age of 47 ± 14.6 (SD) years, and 131 (78.9%) were women. MRI measurements were highly correlated with radiographic measurements (r = 0.882; 95% CI, 0.866-0.898; p < 0.001). A significant correlation was found between length of protrusion and cases classified as either normal PP or PP tear. Patients with a normal PP had a mean protrusion length of 4.11 ± 1.35 mm on radiographs and 2.61 ± 1.31 mm on MR images, whereas those with a PP tear had a mean protrusion length of 4.75 ± 1.53 and 3.05 ± 1.34 mm, respectively. ROC curve analysis showed that protrusion length cutoff values of 5.47 mm measured on radiographs and 3.17 mm on MR images were correlated with MTP PP tear. CONCLUSION. We identified a linear correlation between second metatarsal protrusion measured on MRI and that measured on radiography, with values about 35% higher for the latter. Our study showed an association between length of protrusion of the second metatarsal and PP rupture and identified a cutoff value for the second meta-tarsal overlength that is associated with these tears.

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ABSTRACT Introduction: Moderate and severe bimaxillary protrusion impair the passive lip sealing and the facial and smile esthetics. The extraction of premolars can be avoided by the use of skeletal anchorage to retract both dental arches. This approach brings many advantages such as: prevents premolars extraction; simplifies orthodontic mechanics; there is no volume reduction of a premolar when smiling; control of overbite and gingival exposure. The utilization of this therapeutic approach, when associated with self-ligating brackets, can bring the possibility of spacing the appointments without damage to the treatment efficiency, and allows selection of the most appropriate torque prescriptions for each case. The intra-alveolar miniscrews are indicated for mild cases of bimaxillary protrusion, while extra-alveolar miniscrews may also be indicated for more severe cases. Objective: To report the treatment of three cases of mild, moderate and severe bimaxillary protrusion, in which intra- and extra-alveolar miniscrews were used, according to the retraction required. Conclusion: The retraction of both upper and lower dental arches using orthodontic intra- and extra-alveolar miniscrews, associated with self-ligating brackets, is an excellent tool to correct mild to severe bimaxillary protrusion, thus reducing the need of premolar extraction and simplifying the orthodontic management.

RESUMO Introdução: As biprotrusões moderadas e severas dificultam o selamento labial passivo, comprometem a estética facial e do sorriso. As extrações de pré-molares podem ser evitadas quando se utiliza a ancoragem esquelética como recurso para retrair ambas as arcadas. Essa abordagem traz as seguintes vantagens: evita que o paciente seja submetido ao processo da extração dos pré-molares; simplifica a mecânica ortodôntica; não reduz o volume de um pré-molar de cada lado no sorriso; e auxilia no controle da sobremordida e da exposição gengival. A utilização dessa terapêutica, quando associada aos aparelhos autoligáveis, possibilita maiores intervalos entre as consultas, sem comprometer a eficiência do tratamento, e permite a seleção dos torques mais adequados para essa mecânica. Os miniparafusos intra-alveolares podem ser utilizados na correção de biprotrusões mais suaves, enquanto os extra-alveolares podem ser indicados, também, nos casos mais severos. Objetivo: Relatar os tratamentos de três casos clínicos de biprotrusão leve, moderada e severa, respectivamente, efetuando a retração das arcadas em uma única fase, utilizando miniparafusos intra- e extra-alveolares, conforme a magnitude da retração necessária. Conclusão: A retração das arcadas superior e inferior com miniparafusos ortodônticos intra- e extra-alveolares associados aos aparelhos autoligáveis é um excelente recurso para a correção das biprotrusões de suave a severa, diminuindo a necessidade de extrações de pré-molares e simplificando a mecânica ortodôntica.

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RESUMEN Introducción: la evisceración vaginal después de una cirugía pélvica es una emergencia quirúrgica extremadamente rara. La dehiscencia laparotómica consiste en la desunión y separación precoz de los bordes de una herida quirúrgica suturada, con exteriorización o sin ella del contenido de la cavidad abdominal. Presentación de caso: el caso que aquí se reporta es el de unamujer de 36 años con antecedentes de hipertensión arterial. Intervenida hacia 3 meses de histerectomía abdominal por fibromiomas, sin prolapso uterino. Acude al cuerpo de guardia del hospital por dolor abdominal, sensación de ocupación vaginal y estreñimiento. Niega distensión abdominal y síntomas respiratorios. Ya en el cuerpo de guardia refiere deseos de defecar y al pujar ocurre una protrusión de intestino delgado de más o menos 3 cm, irreductible a través de orificio vaginal. Se realizó laparatomía, revisión por vía vaginal, reducción de las asas intestino delgado y ampliación del orificio por donde se produjo la evisceración. Discusión: se localizaron los bordes del peritoneo parietal, se sutura la cúpula vaginal con puntos continuos y se colocó una malla en el fondo de la pelvis recubierta por peritoneo. Se utilizaron los datos provenientes de la historia clínica hospitalaria. Exámenes complementarios, la entrevista y el examen físico de la paciente, a pesar las probables complicaciones no hubo pérdida de tiempo y la operación fue un éxito. Conclusiones: la evolución fue satisfactoria, gracias a la labor del personal médico que estuvo a cargo del caso.

ABSTRACT Introduction: vaginal evisceration after pelvic surgery is an extremely rare surgical emergency. Laparotomic dehiscence consists of disunity and early separation of the edges of a sutured surgical wound, with or without externalization of the contents of the abdominal cavity. Case presentation: the case reported here is that of a 36-year-old woman with a history of high blood pressure. She underwent 3 months of abdominal hysterectomy for fibromyomas, without uterine prolapse. She comes to the hospital guard corps for abdominal pain, a feeling of vaginal occupation and constipation. He denies abdominal bloating and respiratory symptoms. Already in the body of guard it refers desires to defecate and when pushing a protrusion of small intestine of more or less 3 cm occurs, irreducible through the vaginal opening. Laparatomy, vaginal revision, reduction of the small intestine loops and enlargement of the hole through which evisceration occurred were performed. Discussion: the edges of the parietal peritoneum were located, the vaginal dome was sutured with continuous stitches, and a mesh was placed at the bottom of the pelvis covered by peritoneum. The data from the hospital medical history were used. Complementary examinations, the interview and the physical examination of the patient, despite the probable complications, there was no loss of time and the operation was successful. Conclusions: the evolution was satisfactory, thanks to the work of the medical personnel who were in charge of the case.

RESUMO Introdução: a evisceração vaginal após cirurgia pélvica é uma emergência cirúrgica extremamente rara. A deiscência laparotômica consiste em desunião e separação precoce das bordas de uma ferida cirúrgica suturada, com ou sem externalização do conteúdo da cavidade abdominal. Apresentação do caso: o caso relatado aqui é o de uma mulher de 36 anos com histórico de pressão alta. Ela foi submetida a 3 meses de histerectomia abdominal por fibromiomas, sem prolapso uterino. Ele veio à guarita do hospital devido a dor abdominal, sensação de ocupação vaginal e constipação. Ele nega inchaço abdominal e sintomas respiratórios. Já no corpo de guarda refere desejos de defecar e ao empurrar uma protrusão do intestino delgado de mais ou menos 3 cm, ocorre irredutível através da abertura vaginal. Foram realizadas laparometria, revisão vaginal, redução das alças do intestino delgado e aumento do orifício através do qual a evisceração ocorreu. Discussão: as margens do peritônio parietal foram localizadas, a cúpula vaginal foi suturada com pontos contínuos e uma malha foi colocada na parte inferior da pelve coberta por peritônio. Foram utilizados os dados do histórico médico do hospital. Exames complementares, entrevista e exame físico do paciente, apesar das prováveis ​​complicações, não houve perda de tempo e a operação foi bem-sucedida. Conclusões: a evolução foi satisfatória, graças ao trabalho da equipe médica responsável pelo caso.

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BACKGROUND: To compare dentoskeletal changes produced by the maxillary splint headgear and cervical headgear appliance during the early phase of Class II treatment, specially the initial overjet and upper incisors position. SUBJECTS AND METHODS: In this retrospective study, 28 Class II patients treated with the maxillary splint headgear (MSG, mean age 10.1 ± 1.9 years) and 28 Class II patients treated with cervical headgear (CHG, mean age 9.5 ± 1.9 years) were evaluated before and after treatment. Statistical comparisons between the two groups for cephalometric measurements at T1 and for T2-T1 changes were performed by means of independent sample t tests. RESULTS: The MSG showed a significantly greater reduction of the overjet in comparison to the CHG (- 2.4 mm and - 0.7 mm, respectively) and a significantly greater maxillary incisor uprighting (- 1.8 mm and 0.4 mm, respectively). In the MSG, overjet correction was due mainly to mandibular advancement (3.5 mm), while the correction of molar relationship (3.9 mm) was 64% skeletal and 36% dentoalveolar. In the CHG, the overjet correction was also more skeletal, due to mandibular growth (1.8 mm), while correction of molar relationship (3.5 mm) was 63% dentoalveolar and 37% skeletal. CONCLUSIONS: Both groups showed favorable skeletal mandibular changes, which was more significant in the MSG. Regarding tooth movement, the maxillary splint headgear was more effective in uprighting upper incisors and reducing the overjet than cervical headgear appliance.

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