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Background: Primary bone tumours are uncommon and poorly reported in cats but osteosarcoma (OSA) is the most frequent, mostly inelderly animals. Giant cell-rich OSA is considered rare in the literature representing 3% of all OSA in humans. The mitotic index seemsto have a significant effect on the survival time of cats affected by OSA as well as the tumour histopathological grade. The objective ofthis study was to report the cytological and histopathological findings of a giant cell rich OSA in a 4-year-old cat with persistent felineleukaemia virus (FeLV) antigenaemia.Case: A 4-year-old male neutered cat was referred with a history of persistent FeLV viraemia and pelvic limb lameness with a firmswelling. Previous radiographs of the affected limb revealed bone lysis in the third and fourth metatarsals and increased soft tissueradiopacity in the tarsal region. The referral veterinary assumed it to be osteomyelitis and initiated clinical treatment with antibiotic andanti-inflammatory. The cat was referred after there was no response to medical treatment. The cat was presented with a 5cm diameterulcerated mass, with putrid odor in the pelvic limb. Complementary exams were performed, and abnormalities were found, includingincreased urea, creatinine, calcium and potassium, and decreased sodium and phosphorus. A new radiograph showed exuberant boneproliferation, with increased radiopacity involving tarsal, metatarsal, distal third of tarsal I and II, and distal diaphysis of metatarsal V,without compromising the metaphyseal region of distal diaphysis of metatarsal IV. Chest radiographs and abdominal ultrasound wereunremarkable. Fine-needle aspiration was performed for cytological analysis and revealed a moderate amount of pleomorphic mesenchymal cells with moderate adhesion, cytoplasm with a format ranging from fusiform to stellate, pronounced...(AU)

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Background: Primary bone tumours are uncommon and poorly reported in cats but osteosarcoma (OSA) is the most frequent, mostly inelderly animals. Giant cell-rich OSA is considered rare in the literature representing 3% of all OSA in humans. The mitotic index seemsto have a significant effect on the survival time of cats affected by OSA as well as the tumour histopathological grade. The objective ofthis study was to report the cytological and histopathological findings of a giant cell rich OSA in a 4-year-old cat with persistent felineleukaemia virus (FeLV) antigenaemia.Case: A 4-year-old male neutered cat was referred with a history of persistent FeLV viraemia and pelvic limb lameness with a firmswelling. Previous radiographs of the affected limb revealed bone lysis in the third and fourth metatarsals and increased soft tissueradiopacity in the tarsal region. The referral veterinary assumed it to be osteomyelitis and initiated clinical treatment with antibiotic andanti-inflammatory. The cat was referred after there was no response to medical treatment. The cat was presented with a 5cm diameterulcerated mass, with putrid odor in the pelvic limb. Complementary exams were performed, and abnormalities were found, includingincreased urea, creatinine, calcium and potassium, and decreased sodium and phosphorus. A new radiograph showed exuberant boneproliferation, with increased radiopacity involving tarsal, metatarsal, distal third of tarsal I and II, and distal diaphysis of metatarsal V,without compromising the metaphyseal region of distal diaphysis of metatarsal IV. Chest radiographs and abdominal ultrasound wereunremarkable. Fine-needle aspiration was performed for cytological analysis and revealed a moderate amount of pleomorphic mesenchymal cells with moderate adhesion, cytoplasm with a format ranging from fusiform to stellate, pronounced...

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Background: Multilobular tumor of bone (MTB) is a primary bone neoplasm, uncommon in dogs. This tumor was called ofmany names for a long time, as: chondroma rodens, multilobular osteochondrosarcoma, multilobular osteoma, multilobularchondroma, calcificating aponeurotic fibroma, although MTB was preferred chosen, because these other name could becorrelated with humans tumors. This tumor is observed specially in skull bone, although it was reported in zygomaticarc, hard palate, axilla, spine and penis. Mostly happen in big breeds dogs, and middle to old age patients. Clinical signsdepending of region and how aggressive the tumor is, usually are related to compression of any structure. The growth ofMTB is frequently slow and progressive, locally invasive, occurring relapse after surgical revomal, although the tumorhas low to moderate metastatic potential. The aim of this study is to report a case of MTB in a female dog and describeanatomopathological changes.Case: A female dog, mixed breed, 13 year-old, of middleweight was admitted in Pathology Department of College of Agricultural Sciences and Veterinary Medicine (FCAV-Unesp), Campus of Jaboticabal - SP, to be undergone to necropsy. Thepatient have never shown any epileptic crisis or neurologic signs. In macroscopic examination was found a mass in skull,which invaded the orbit and frontal sinus, but it was not invading brain cavity. The neoplasm had and irregular surface, firmconsistent, color was white mixed to red areas, after cut it was granular and rough, and had some point mineralized areas.The lobs of lung had much firm masses, colored gray to white. In cytology it was observed fusiform to polyhedric isolatedmesenchymal cells, moderated pleomorphic, basophilic cytoplasm, thin granulated nuclear chromatin, and visible nucleolithat was involved by eosinophilic extracellular matrix...(AU)

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Background: Multilobular tumor of bone (MTB) is a primary bone neoplasm, uncommon in dogs. This tumor was called ofmany names for a long time, as: chondroma rodens, multilobular osteochondrosarcoma, multilobular osteoma, multilobularchondroma, calcificating aponeurotic fibroma, although MTB was preferred chosen, because these other name could becorrelated with humans’ tumors. This tumor is observed specially in skull bone, although it was reported in zygomaticarc, hard palate, axilla, spine and penis. Mostly happen in big breeds dogs, and middle to old age patients. Clinical signsdepending of region and how aggressive the tumor is, usually are related to compression of any structure. The growth ofMTB is frequently slow and progressive, locally invasive, occurring relapse after surgical revomal, although the tumorhas low to moderate metastatic potential. The aim of this study is to report a case of MTB in a female dog and describeanatomopathological changes.Case: A female dog, mixed breed, 13 year-old, of middleweight was admitted in Pathology Department of College of Agricultural Sciences and Veterinary Medicine (FCAV-Unesp), Campus of Jaboticabal - SP, to be undergone to necropsy. Thepatient have never shown any epileptic crisis or neurologic signs. In macroscopic examination was found a mass in skull,which invaded the orbit and frontal sinus, but it was not invading brain cavity. The neoplasm had and irregular surface, firmconsistent, color was white mixed to red areas, after cut it was granular and rough, and had some point mineralized areas.The lobs of lung had much firm masses, colored gray to white. In cytology it was observed fusiform to polyhedric isolatedmesenchymal cells, moderated pleomorphic, basophilic cytoplasm, thin granulated nuclear chromatin, and visible nucleolithat was involved by eosinophilic extracellular matrix...

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Background: The multilobular tumor of bone, also known as chondroma rodens, is a primary tumor of bones with low frequency in dogs. It is considered a slow-growth malignant tumor, locally invasive, able to compress and invade the cerebral tissue. Its occurrence is greater in the flat bones of skull and hard palate. The clinical signs depend on the tumor location and usually are related to the compression of adjacent structures. The aim of this study is present a multilobular tumor of bone clinical case in a dog with has progressive growth on the skulls frontal part and facial deformation. Clinical, laboratory and therapeutic findings will be discussed in the report. Case: An 8-year-old male crossbred castrated dog, weighing 31 kg, presenting progressive growth in the skull was examined at the University of Caxias do Sul veterinary clinic. According to the owner, the tumor was firstly observed about 3 months ago, and the dog became prostrated since then. In the clinical examination, was noticed an enlarged, symmetric and diffuse volume in the skulls frontal part, facial deformation, especially around the ocular region, causing visual deficit. It wasnt detected any other systemic alterations. The radiography of the skull revealed a soft tissue increased volume, suggesting a mass or an encapsulated abscess. Serum biochemistry demonstrated an increase of alcaline phosphatase activity. The other hematological and biochemical parameters were within normal limits. Fine needle aspiration was performed, showing compatible result with bone neoplasm. It was chosen to make a surgical resection, starting with a cross-shaped incision on medial portion of the skull, followed by a skin disclosure to expose the tumor. With the assistance of an orthopedical chisel and metzembaum scissors, the mass was removed. The tumor presented steady and sanded aspect, reddish colored with whitish areas...(AU)

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Background: The multilobular tumor of bone, also known as chondroma rodens, is a primary tumor of bones with low frequency in dogs. It is considered a slow-growth malignant tumor, locally invasive, able to compress and invade the cerebral tissue. Its occurrence is greater in the flat bones of skull and hard palate. The clinical signs depend on the tumor location and usually are related to the compression of adjacent structures. The aim of this study is present a multilobular tumor of bone clinical case in a dog with has progressive growth on the skull’s frontal part and facial deformation. Clinical, laboratory and therapeutic findings will be discussed in the report. Case: An 8-year-old male crossbred castrated dog, weighing 31 kg, presenting progressive growth in the skull was examined at the University of Caxias do Sul veterinary clinic. According to the owner, the tumor was firstly observed about 3 months ago, and the dog became prostrated since then. In the clinical examination, was noticed an enlarged, symmetric and diffuse volume in the skull’s frontal part, facial deformation, especially around the ocular region, causing visual deficit. It wasn’t detected any other systemic alterations. The radiography of the skull revealed a soft tissue increased volume, suggesting a mass or an encapsulated abscess. Serum biochemistry demonstrated an increase of alcaline phosphatase activity. The other hematological and biochemical parameters were within normal limits. Fine needle aspiration was performed, showing compatible result with bone neoplasm. It was chosen to make a surgical resection, starting with a cross-shaped incision on medial portion of the skull, followed by a skin disclosure to expose the tumor. With the assistance of an orthopedical chisel and metzembaum scissors, the mass was removed. The tumor presented steady and sanded aspect, reddish colored with whitish areas...

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ABSTRACT: Osteosarcoma (OSA) is the most common bone tumor diagnosed in dogs and represents approximately 85% of canine skeletal tumors. The most commonly employed therapy is amputation of the limb followed by chemotherapy. However, preservation of the afflicted limb has been successful for patients with concomitant neurological or orthopedic conditions, which are contraindications to the complete amputation, or with owners reluctant to the possibility of amputation. For these reasons, the purpose of this study was to describe the technical procedures that allowed limb salvage through the use of pedicle frozen grafts in a dog with femoral OSA. Surgical procedures consisted of a femoral diaphyseal osteotomy with tearing of the soft tissues; thus, creating a bone pedicle that was frozen in liquid nitrogen according to the protocol outlined by TSUCHIYA et al. (2005). Limb function remained satisfactory for six months.

RESUMO: Dentre os tumores ósseos que acometem os cães, o osteossarcoma (OSA) é o mais frequentemente diagnosticado e representa 85% das neoplasias de origem esquelética. A terapêutica comumente indicada é a amputação do membro, seguida de quimioterapia. No entanto, a preservação do membro afetado tem sido realizada em pacientes com afecções neurológicas ou ortopédicas concomitantes, que contraindicam a amputação radical ou em caso de tutores relutantes em aceitar a amputação. Em razão disso, o objetivo do presente trabalho é descrever a técnica de preservação de membro através de pedículo congelado em nitrogênio líquido em um cão com osteossarcoma de fêmur. A técnica cirúrgica empregada consistiu na osteotomia diafisária do fêmur, com divulsão dos tecidos moles, criando assim o pedículo ósseo que foi congelado em nitrogênio líquido, seguindo o protocolo realizado por TSUCHIYA et al. (2005). O cão permaneceu com a função satisfatória do membro por um período de seis meses.

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Osteosarcoma (OSA) is the most common bone tumor diagnosed in dogs and represents approximately 85% of canine skeletal tumors. The most commonly employed therapy is amputation of the limb followed by chemotherapy. However, preservation of the afflicted limb has been successful for patients with concomitant neurological or orthopedic conditions, which are contraindications to the complete amputation, or with owners reluctant to the possibility of amputation. For these reasons, the purpose of this study was to describe the technical procedures that allowed limb salvage through the use of pedicle frozen grafts in a dog with femoral OSA. Surgical procedures consisted of a femoral diaphyseal osteotomy with tearing of the soft tissues; thus, creating a bone pedicle that was frozen in liquid nitrogen according to the protocol outlined by TSUCHIYA et al. (2005). Limb function remained satisfactory for six months.(AU)

Dentre os tumores ósseos que acometem os cães, o osteossarcoma (OSA) é o mais frequentemente diagnosticado e representa 85% das neoplasias de origem esquelética. A terapêutica comumente indicada é a amputação do membro, seguida de quimioterapia. No entanto, a preservação do membro afetado tem sido realizada em pacientes com afecções neurológicas ou ortopédicas concomitantes, que contraindicam a amputação radical ou em caso de tutores relutantes em aceitar a amputação. Em razão disso, o objetivo do presente trabalho é descrever a técnica de preservação de membro através de pedículo congelado em nitrogênio líquido em um cão com osteossarcoma de fêmur. A técnica cirúrgica empregada consistiu na osteotomia diafisária do fêmur, com divulsão dos tecidos moles, criando assim o pedículo ósseo que foi congelado em nitrogênio líquido, seguindo o protocolo realizado por TSUCHIYA et al. (2005). O cão permaneceu com a função satisfatória do membro por um período de seis meses.(AU)

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Tumores ósseos primários são raros em felinos, afetam principalmente animais idosos e apresentam predileção pelo esqueleto apendicular. Este trabalho relata o caso de um felino macho de dezoito meses de idade, mestiço, em adequado estado nutricional, que foi atendido com histórico de massa de crescimento rápido no membro pélvico direito. Apresentava-se ativo, porém com claudicação e dor no local. O exame físico e radiográfico levantou a suspeita de osteossarcoma apendicular, o que foi posteriormente confirmado por meio de histopatologia. O paciente foi submetido à amputação por meio de desarticulação coxofemoral. Devido ao baixo índice metastático nessa espécie não foram realizados protocolos quimioterápicos, e nos retornos periódicos o exame radiográfico não apresentou evidência de metástase. A baixa incidência nessa espécie felina, assim como a idade do paciente, justificam a relevância do presente relato.

Primary bone tumors are rare in cats; they affect mainly older animals and have a predilection for the appendicular skeleton. This paper reports the case of an eighteen-month-old male mongrel cat. The patient was active and in adequate nutritional status, but had a rapidly growing mass in the right pelvic limb, which caused lameness and pain at the site. Physical and radiographic examination suggested appendicular osteosarcoma, which was subsequently confirmed by histopathology. The patient underwent amputation by hip disarticulation. Due to the low metastatic rate in this species, chemotherapy protocols were not performed. Periodic post-surgical radiographic examinations showed no evidence of metastasis. Both the low incidence of this disease in this feline species and the patient's young age justify the relevance of this report.

Los tumores óseos primarios son poco frecuentes en los gatos y afectan principalmente a animales de edad avanzada, localizándose en la mayor parte de los casos en huesos largos. Este trabajo relata el caso de un gato macho de dieciocho meses de edad, mestizo y en adecuado estado nutricional, que se presentó a consulta con histórico de masa de crecimiento rápido en el miembro posterior derecho. El paciente se encontraba activo, aunque presentaba presencia de claudicación y dolor local. El examen físico y las radiografías llevaron a un diagnóstico presuntivo de osteosarcoma, posteriormente confirmado a través de la histopatología. El paciente fue amputado mediante desarticulación coxo femoral. Dado que el índice de metástasis es bajo en los gatos, no se indicó la realización de quimioterapia; y en los controles clínicos y radiográficos no se detectó la presencia de metástasis. La justificativa del presente relato se fundamenta en la baja incidencia de osteosarcomas en estos felinos, particularmente en animales de baja edad.

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Tumores ósseos primários são raros em felinos, afetam principalmente animais idosos e apresentam predileção pelo esqueleto apendicular. Este trabalho relata o caso de um felino macho de dezoito meses de idade, mestiço, em adequado estado nutricional, que foi atendido com histórico de massa de crescimento rápido no membro pélvico direito. Apresentava-se ativo, porém com claudicação e dor no local. O exame físico e radiográfico levantou a suspeita de osteossarcoma apendicular, o que foi posteriormente confirmado por meio de histopatologia. O paciente foi submetido à amputação por meio de desarticulação coxofemoral. Devido ao baixo índice metastático nessa espécie não foram realizados protocolos quimioterápicos, e nos retornos periódicos o exame radiográfico não apresentou evidência de metástase. A baixa incidência nessa espécie felina, assim como a idade do paciente, justificam a relevância do presente relato.(AU)

Primary bone tumors are rare in cats; they affect mainly older animals and have a predilection for the appendicular skeleton. This paper reports the case of an eighteen-month-old male mongrel cat. The patient was active and in adequate nutritional status, but had a rapidly growing mass in the right pelvic limb, which caused lameness and pain at the site. Physical and radiographic examination suggested appendicular osteosarcoma, which was subsequently confirmed by histopathology. The patient underwent amputation by hip disarticulation. Due to the low metastatic rate in this species, chemotherapy protocols were not performed. Periodic post-surgical radiographic examinations showed no evidence of metastasis. Both the low incidence of this disease in this feline species and the patient's young age justify the relevance of this report.(AU)

Los tumores óseos primarios son poco frecuentes en los gatos y afectan principalmente a animales de edad avanzada, localizándose en la mayor parte de los casos en huesos largos. Este trabajo relata el caso de un gato macho de dieciocho meses de edad, mestizo y en adecuado estado nutricional, que se presentó a consulta con histórico de masa de crecimiento rápido en el miembro posterior derecho. El paciente se encontraba activo, aunque presentaba presencia de claudicación y dolor local. El examen físico y las radiografías llevaron a un diagnóstico presuntivo de osteosarcoma, posteriormente confirmado a través de la histopatología. El paciente fue amputado mediante desarticulación coxo femoral. Dado que el índice de metástasis es bajo en los gatos, no se indicó la realización de quimioterapia; y en los controles clínicos y radiográficos no se detectó la presencia de metástasis. La justificativa del presente relato se fundamenta en la baja incidencia de osteosarcomas en estos felinos, particularmente en animales de baja edad.(AU)

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