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The present study investigated the effect of adding allopathic doxorubicin (DOX 0.3 µg/mL), the vehicle of ultradiluted/dynamized doxorubicin (0.2 % ethanol), different dynamizations of ultradiluted/dynamized doxorubicin (DOX 6CH, DOX 12CH and DOX 30CH), both in the absence or presence of chemical stress induced by doxorubicin at 0.3 µg/mL on follicular survival and activation, antioxidant capacity of the medium, Catalase activity (CAT), production of reactive protein thiol, maintenance of type I and III collagen fibers and accumulation of lipofuscin in porcine ovarian tissue cultured in vitro for 48 hours. To do this, part of the ovarian tissue fragments was fixed for the uncultured control and the rest were cultured in: MEM (cultured control), DOX 0.3 µg/mL, Ethanol, DOX 6CH, DOX 12CH, DOX 30CH, DOX (0.3 µg/mL) + DOX 6CH, DOX (0.3 µg/mL) + DOX 12CH, DOX (0.3 µg/mL) + DOX 30CH treatments. The results showed that, in general, ultradiluted/dynamized doxorubicin (DOX 6CH, DOX 12CH and DOX 30CH) mitigated the toxic effect of allopathic doxorubicin (0.3 µg/mL) on the morphology of preantral follicles, the content of type I and III collagen fibers, and the production of lipofuscin in the tissue. However, only DOX (0.3 µg/mL) + DOX 6CH attenuated the oxidative stress induced by DOX (0.3 µg/mL), maintaining adequate CAT activity that was similar to the uncultured control. Additionally, when the three isolated ultradiluted/dynamized doxorubicin were considered, only DOX 12CH increased the reduced thiol levels compared to the uncultured control and MEM. In conclusion, supplementing the culture medium with ultradiluted/dynamized DOX (DOX 6CH, DOX 12CH and DOX 30CH) attenuated the toxicity induced by allopathic doxorubicin during the in vitro culture of pig preantral follicles enclosed in ovarian tissue.

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Homeopathy uses the "similitude principle" to arouse a therapeutic reaction in the body against its own disorders. For this to occur optimally, the medicinal pathogenetic effects must present similarity with the totality of the individual's symptoms. To assess if this similarity has been successfully achieved, Hahnemann states that "improvement in the disposition and mind"­i.e., subjective well-being­is the most important parameter to consider. Aim Our aim was to perform a narrative review of the literature, exploring what is known about subjective well-being as a marker of therapeutic action, and to formulate ways in which subjective well-being might be quantifiable and applied in future homeopathy research. The concept of subjective well-being has been extensively studied in the complementary and conventional medical literature. Improved well-being has been observed in clinical trials, including those in the fields of positive psychology and meditation. Positive subjective outcomes of this nature are supported by objective evidence through associated changes in brain oscillatory activity using electroencephalography and/or "brain mapping" by functional magnetic resonance imaging. Neurophysiological responses in the brain have been identified in subjects after they ingested a homeopathic medicine. The concept of subjective well-being is supported by a body of literature and is a measurable entity. When viewed from the perspective of electrophysiological changes, brain activity is an objective neurophysiological biomarker with a potential to quantify individual well-being in the context of homeopathy research.

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En el panorama de la salud, el cuerpo humano, en su estado natural, se revela como una intrincada unidad que opera en armonía para mantener el equilibrio dinámico. Sin embargo, esta homeostasis puede verse afectada, dando lugar a la dualidad y a trastornos que comprometen la estabilidad vital. Este artículo propone una reflexión sobre la perspectiva homeopática, destacando su enfoque único en comparación con la medicina convencional. Diferenciándose al tratar al individuo como un todo integrado, la Homeopatía reconoce la transitoriedad de la dualidad representada por las enfermedades y enfatiza la importancia de la armonía entre el cuerpo y la mente en la búsqueda de la homeostasis. Inspirada en las ideas de Hahnemann, la Homeopatía se destaca por su visión holística, rechazando el dualismo estricto y proponiendo intervenciones que van más allá de la supresión de los síntomas. Anclada en la ley de los similares, busca sustancias que reproduzcan los síntomas del paciente en un estado saludable, buscando una cura profunda y la restauración de la unidad dinámica del organismo. A pesar de los desafíos, como la resistencia y la falta de métodos de investigación universalmente aceptados, la Homeopatía persiste a nivel mundial, sugiriendo un valor único. Este artículo promueve una reflexión sobre el enfoque homeopático, enfatizando su contribución a la comprensión de la salud y su papel en el panorama terapéutico.

n the landscape of health, the human body, in its natural state, reveals itself as an intricate unity, operating harmoniously to maintain dynamic balance. However, this homeostasis can be disrupted, leading to duality and disturbances that compromise vital stability. This article reflects on the homeopathic perspective, highlighting its unique approach compared to conventional medicine. Distinguishing itself by treating the individual as an integrated whole, homeopathy recognizes the transience of duality represented by diseases and emphasizes the importance of harmony between body and mind in the pursuit of homeostasis.Inspired by Hahnemann's ideas, homeopathy stands out for its holistic view, rejecting strict dualism and proposing interventions that go beyond symptom suppression. Anchored in the Law of Similars, it seeks substances that would reproduce the patient's symptoms in a healthy state, aiming for a profound cure and the restoration of the dynamic unity of the organism. Despite challenges, such as resistance and a lack of universally accepted research methods, homeopathy persists globally, suggesting unique value. This article encourages reflection on the homeopathic approach, emphasizing

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Aconitum napellus L. is a popular medicinal plant extensively used in homeopathy. This article provides detailed morphology and microscopy, including the anatomical and histochemical features of the herb, to aid authentication and quality control. In cross-section, the root in secondary growth shows the phloem surrounded by pericyclic fibers and a well-developed xylem. The stem is irregular in outline, displaying unicellular trichomes and many free collateral vascular bundles encircling the pith. The leaf is dorsiventral, hypostomatic with anomocytic and anisocytic stomata, and shows non-glandular trichomes. The floral parts are characterized by uniseriate epidermises, homogeneous mesophyll, anomocytic stomata on the abaxial surface, trichomes, and oval pollen grains. The tissue fragments in powdered herbs show these characteristics and have numerous starch grains with thimble-shaped, linear or star-shaped hilum. The detailed macroscopic and microscopic analysis provided in this study can help in the authentication and quality control of A. napellus raw materials. RESEARCH HIGHLIGHTS: Key anatomical, micromorphological, and microchemical features of Aconitum napellus are described. The results of the study can support the taxonomy of the genus Aconitum. Morphological standardization of the species reported here is helpful in the quality control of this herb.

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Os desastres naturais tem se intensificado nas últimas décadas causando impactos sobre a saúde humana e todas as esferas: física, psíquica e espiritual. Dentre as diferentes abordagens terapêuticas a Homeopatia surge como uma opção suave, segura, duradoura e de baixo custo. O objetivo deste artigo é mostrar as possibilidades de utilização da abordagem e dos medicamentos homeopáticos nestes eventos. Para tanto consideramos a Homeopatia aplicada nos diferentes níveis de atuação e complexidade dos cuidados à saúde. Concluindo, salientamos que a Homeopatia e os Médicos Homeopatas podem e devem participar nas ações de acolhimento e cuidado à saúde das pessoas direta ou indiretamente atingidas por este trágico evento.

Natural disasters have intensified in recent decades, causing impacts on human health and all spheres: physical, psychological and spiritual. Among the different therapeutic approaches, Homeopathy appears as a gentle, safe, long-lasting and low-cost option. The objective of this article is to show the possibilities of using the homeopathic approach and medicines in these events. To this end, we consider Homeopathy applied at different levels of activity and complexity of health care. In conclusion, we emphasize that Homeopathy and Homeopathic Doctors can and should participate in welcoming and caring for the health of people directly or indirectly affected by this tragic event.

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Este artigo tem como objeto o papel da narração das histórias de vida dos pacientes durante a consulta homeopática na promoção da saúde e produção de autonomia dos sujeitos. Objetivos e Metodologia: A partir da abordagem sócio-histórica, foi realizada revisão de literatura narrativa, a fim de identificar os limites e as possibilidades do ato de narrar na racionalidade médica homeopática para a produção de subjetividades e autonomia na trajetória singular de cada indivíduo levar sua vida. Considerações Finais: Há atualidade e consonância de conceitos da racionalidade médica homeopática com o paradigma contemporâneo da promoção da saúde; as narrativas produzidas no ato da anamnese homeopática têm a potencialidade de ampliar a compreensão médica e do indivíduo para além da doença, analisando o fenômeno existencial do adoecimento. A anamnese homeopática, ao valorizar as experiências existenciais relatadas no âmbito de uma consulta, concorre para uma valorização dos sujeitos, o que contribuiria para a construção de sua subjetividade, autonomia e emponderamento.

This article focuses on the role of narrating patients' life stories during homeopathic consultations in promoting health and producing autonomy for subjects. Objectives and Methodology: Using a socio-historical approach, a narrative literature review was carried out in order to identify the limits and possibilities of the act of narrating in homeopathic medical rationality for the production of subjectivities and autonomy in the unique trajectory of each individual. your life. Final Considerations: The concepts of homeopathic medical rationality are current and consistent with the contemporary paradigm of health promotion; The narratives produced in the act of homeopathic anamnesis have the potential to expand medical and individual understanding beyond the disease, analyzing the existential phenomenon of illness. Homeopathic anamnesis, by valuing the existential experiences reported in the context of a consultation, contributes to an appreciation of the subjects, which would contribute to the construction of their subjectivity, autonomy and empowerment.

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A Homeopatia é um sistema terapêutico baseado no princípio da similitude. A experimentação sistemática de substâncias em pessoas sadias permite conhecer os sintomas que elas provocam (patogenesia). A reunião de diferentes patogenesias forma as Matérias Médicas, dentre as quais destaca-se como referência até hoje The Guiding Symptoms of Our Materia Medica, de Constantine Hering. Objetivo: Avaliar a concordância da experimentação atual de um medicamento homeopático (Agaricus muscarius) com os dados constantes em Matéria Médica de referência. Metodologia: Foi realizada uma experimentação patogenética breve no formato de um ensaio randomizado duplo- -cego, placebo-controlado com cross-over. Foi experimentado o medicamento Agaricus muscarius na dinamização 30 CH. A experimentação teve duração de 8 semanas. Os sintomas foram classificados, graduados e ordenados para análise estatística. Foram utilizados os testes de Kolgomorov- Smirnov para normalidade dos dados e t de Student e ANOVA para comparação entre grupos. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa com Seres Humanos da Fundação Universidade Federal de Mato Grosso do Sul. Resultados: Não foi encontrada diferença significativa entre os escores de correspondência de sintomas dos participantes com a Matéria Médica quando usaram medicamento e quando usaram placebo. Mais da metade dos sintomas teve um grau moderado a alto de correspondência com a Matéria Médica (59,4%) e um grau elevado de associação com o uso do medicamento (53,1%). Conclusão: A reexperimentação de Agaricus muscarius produziu sintomas em sua maioria correspondentes àqueles registrados em Matéria Médica de referência e com alto grau de associação ao uso do medicamento.

Homeopathy is a therapeutic system based on the similitude principle, Systematic substance experimentation in healthy subjects allows knowing the symptoms they cause (pathogenesis). The assemblage of various pathogeneses yields homeopathic therapeutic compendia called Materia Medica, among which The Guiding Symptoms of Our Materia Medica, by Constantine Hering, remains an important reference. Objective: Evaluate the concordance between the present experimentation of a homeopathic medicine (Agaricus muscarius) and the data from a referential Materia Medica. Methods: A brief pathogenetic experimentation was performed a randomized, double-blind, placebo- -controlled cross-over trial. The medicine Agaricus muscarius was experimented as 30 CH dynamization. The experimentation lasted for 8 weeks. Symptoms were classified, graded and ordered for statistical analysis. Kolmogorov-Smirnov test was used for data normality and t-Student test and ANOVA for between-group comparison. The research was approved by the Human Beings Research Ethics Committee from the Foundation Federal University of Mato Grosso do Sul. Results: No significant differences in symptom correspondence scores were noted when participants were administered remedy vs placebo. More than half of experimentation pathogenesis symptoms had a moderate to high correspondence degree to the Materia Medica (59,4%) and a high association degree to the use of remedy (53,1%). Conclusion: Reexperimentation of Agaricus muscarius has produced symptoms mostly correspondent

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O inconsciente coletivo é um conceito formulado por Carl G. Jung que consiste de um nível de consciência primordial, compartilhado pelos membros de comunidade no âmbito familiar, racial, social, grupal, etc. e mediado por reações humanas instintivas ancestrais que não se baseiam na experiência individual. A assim chamada Ressonância Mórfica, elaborada por Rupert Sheldrake, amplia o conceito de inconsciente coletivo, pois opera em todo o universo, envolvendo elementos de todos os reinos da natureza. Representa uma memória coletiva auto-organizada influenciada por padrões semelhantes do passado. Poderíamos inferir que a totalidade de sintomas de uma patogenesia de uma substância é também um conjunto de símbolos e arquétipos. Cada substância está ligada aos seus ancestrais de uma mesma família botânica ou animal, como também ligada à formação geológica do nosso planeta. De forma semelhante, existe uma consciência de grupo que influencia todos os membros do sistema familiar. A verdadeira individualidade psíquica da criança é uma combinação de fatores coletivos, pois não apenas o corpo da criança, mas também sua alma, provém da série dos antepassados, no sentido de que ela não pode ser distinguida individualmente da alma coletiva da humanidade. Por estar espalhada por toda a parte na alma coletiva, a criança pequena "percebe" não apenas os condicionamentos mais profundos dos pais, mas também, em um âmbito mais extenso, o bem e o mal existentes nas profundezas da alma humana. Todos nós somos influenciados pelas dinâmicas sistêmicas do mundo que nos cerca. A tendência é repetir inconscientemente os problemas do passado e levá-los adiante. Desta forma, a noção de individualidade é relativizada. Ao estudarmos os medicamentos agregando-os por algum tipo de analogia para formar grupos ou famílias seja de origem mineral, vegetal ou animal, o conjunto de características, temas, arquétipos, sensações, sintomas comuns, etc. de um determinado grupo forma um campo mórfico no espaço-tempo, a qual os pacientes por ressonância ou similitude se ligam inconscientemente. O campo eletromagnético de cada indivíduo, mediado pelos seus sistemas de crenças e campos mórficos familiares, liga-se aos campos informacionais dos mitos, dos arquétipos e do inconsciente coletivo humano similares, podendo levar ao adoecimento.

The collective unconscious is a concept formulated by Carl G. Jung that consists of a primordial level of consciousness, shared by community members in the family, racial, social, group, etc. spheres and mediated by ancestral instinctive human reactions that are not based on individual experience. The so-called Morphic Resonance, elaborated by Rupert Sheldrake, expands the concept of the collective unconscious, as it operates throughout the universe, involving elements from all kingdoms of nature. It represents a self-organizing collective memory influenced by similar patterns from the past. We could infer that the totality of symptoms of a pathogenesis of a substance is also a set of symbols and archetypes. Each substance is linked to its ancestors from the same botanical or animal family, as well as linked to the geological formation of our planet. Similarly, there is a group consciousness that influences all members of the family system. The true psychic individuality of the child is a combination of collective factors, for not only the child's body, but also his soul, comes from the series of ancestors, in the sense that it cannot be distinguished individually from the collective soul of humanity. Because it is scattered everywhere in the collective soul, the young child "perceives" not only the deeper conditionings of the parents, but also, in a wider scope, the good and evil existing in the depths of the human soul. We are all influenced by the systemic dynamics of the world around us. The tendency is to unconsciously repeat the problems of the past and carry them forward. In this way, the notion of individuality is relativized. When we study medicines by aggregating them by some kind of analogy to form groups or families, whether of mineral, vegetable or animal origin, the set of characteristics, themes, archetypes, sensations, common symptoms, etc. of a given group forms a morphic field in space-time, to which patients by resonance or similarity unconsciously attach themselves. Each individual's electromagnetic field, mediated by their belief systems and familiar morphic fields, is linked to the informational fields of similar myths, archetypes, and the human collective unconscious, and can lead to illness.

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Dentre as várias vertentes de pesquisa e prática homeopática pós-hahnemanniana, a Homeopatia Constitucional leva em consideração os aspectos morfofisiológicos: a biotipologia, o temperamento, as diáteses, não como noções absolutas, mas inseridas no seu devido lugar dentro da Doutrina e Técnicas de aplicação da Homeopatia. O conceito básico persiste sendo a semelhança precisa entre os sinais de um remédio e os mesmos sinais encontrados num paciente. A gravidez é um estado fisiológico que resulta na formação de um ser do qual podemos conhecer os progenitores. É uma oportunidade de abordar este ser diante das imperfeições de terreno que lhes podem ser transmitidas. A homeopatia é a única terapêutica prática, pois é inofensiva à criança e conduz um tratamento "eugênico", permitindo que a criança seja bem constituída.

Among the various aspects of post-Hahnemannian homeopathic research and practice, Constitutional Homeopathy considers morphophysiological aspects: biotypology, temperament and diatheses, not as absolute notions, but inserted in their due place within the Doctrine and Application Techniques of Homeopathy. The basic concept remains the precise similarity between the signs of a medicine and the same signs found in a patient. Pregnancy is a physiological state that results in the formation of a being whose parents we can know. It is an opportunity to approach this being in the face of the imperfections of the terrain that can be transmitted to them. Homeopathy is the only practical therapy, as it is harmless to the child and provides a "eugenic" treatment, allowing the child to be well constituted.

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This study evaluated the effects of feeding an ultra-diluted complex to dairy cows during the transition period and early lactation. Thirty multiparous pregnant dairy cows were blocked and randomly assigned to either a placebo control (CON) group or ultra-diluted complex (UD) group. The CON group received a placebo (basal diet + 40 g/cow/day of expanded silicate), while the UD group received the ultra-diluted complex (basal diet + 40 g/cow/day of PeriParto Transição-RealH, composed of ultra-diluted substances + vehicle: expanded silicate). Cows were evaluated from 30 days before the expected calving date until 60 days in milk (DIM) for sample and data collection. Post-partum dry matter intake (DMI) was not affected by the treatment. Cows fed UD had higher DMI relative to BW. Feeding UD increased milk lactose content and decreased milk protein content. Cows fed UD had lower somatic cell counts in the third and fourth week of lactation. Cows fed UD showed a tendency for higher liver health index. Using UD during the transition period and early lactation may benefit liver and udder health of dairy cows with no detrimental effect on milk performance.