RESUMO

Understanding the neurophysiological mechanisms of schizophrenia (SZ) is one of the challenges of neuroscience. Many anatomical and functional studies have pointed to problems in brain connectivity in SZ individuals. However, little is known about the relationships between specific brain regions and impairments in brain connectivity in SZ individuals. Herein we propose a new approach using time-varying graphs and the motif synchronization method to build dynamic brain functional networks (BFNs). Dynamic BFNs were constructed from resting-state electroencephalography (rs-EEG) of 14 schizophrenia (SZ) individuals and 14 healthy controls (HCs). BFNs were evaluated based on the percentage of synchronization importance between a pair of regions (considering external and internal interactions) over time. We found differences in the directed interaction between brain regions in SZ individuals compared to the control group. Our method revealed low bilaterally directed interactions between the temporal lobes in SZ individuals compared to HCs, indicating a potential link between altered brain connectivity and the characteristic symptoms of schizophrenia. From a clinical perspective, these results shed light on developing new therapeutic approaches targeting these specific neural interactions that are altered in individuals with SZ. This knowledge allows the application of better interventions focused on restoring or compensating for interrupted connectivity patterns.

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RESUMO

This study investigates nineteenth century natural history practices through the lens of the Actor-Network Theory, which posits that scientific practice is shaped by an intricate network of interactions between human and non-human actors. At the core of this research is the analysis of correspondence between Charles Darwin and his collaborators during the Cirripedia Project, which unveils a complex landscape of negotiations with illustrators, funders, specimen owners, and translators, among other stakeholders and interested parties. The study goes beyond the final outcomes of scientific research, delving into behind-the-scenes interactions, and hidden constructions, shedding light on the complex dynamics and actors that conventional scientific narratives often overlook. In general, this approach provides a detailed and insightful view of the underlying processes of nineteenth-century scientific practice, underscoring the importance of epistolary correspondence as a central element in producing scientific knowledge at the time, and in particular it reveals to us how much Darwin was himself involved in the production of his famous work on barnacles. By emphasizing the intricacies of research, this study enriches our understanding of Darwin's work as well as natural history practices in the 19th century, highlighting the complexity and diversity of actors and agents involved in shaping scientific knowledge.

RESUMO

BACKGROUND: Lichens are micro-ecosystems relying on diverse microorganisms for nutrient cycling, environmental adaptation, and structural support. We investigated the spatial-scale dependency of factors shaping the ecological processes that govern lichen-associated bacteria. We hypothesize that lichens function as island-like habitats hosting divergent microbiomes and promoting landscape gamma-diversity. Three microenvironments -thalli, substrates, and neighboring soils- were sampled from four geographically overlapping species of Peltigera cyanolichens, spanning three bioclimatic zones in the Chilean Patagonia, to determine how bacterial diversity, assembly processes, ecological drivers, interaction patterns, and niche breadth vary among Peltigera microenvironments on a broad geographical scale. RESULTS: The hosts' phylogeny, especially that of the cyanobiont, alongside climate as a secondary factor, impose a strong ecological filtering of bacterial communities within Peltigera thalli. This results in deterministically assembled, low diverse, and phylogenetically convergent yet structurally divergent bacterial communities. Host evolutionary and geographic distances accentuate the divergence in bacterial community composition of Peltigera thalli. Compared to soil and substrate, Peltigera thalli harbor specialized and locally adapted bacterial taxa, conforming sparse and weak ecological networks. CONCLUSIONS: The findings suggest that Petigera thalli create fragmented habitats that foster landscape bacterial gamma-diversity. This underscores the importance of preserving lichens for maintaining a potential reservoir of specialized bacteria.

RESUMO

The inappropriate use of electronic devices can affect the psychological and physical health of children and adolescents. Therefore, it is essential to accompany them and promote media literacy to ensure a healthy and responsible use of technology. On occasions that depend on a multifactorial complex, the inappropriate use of networks can trigger problematic consumption and seriously affect the lives of young people. In 2022, the World Health Organization recognized, through ICD-11, the addiction to video games and used the term "problematic use" for the Internet and social networks. This article attempts to update professionals on new trends in the consumption of social networks, video games, and online gambling platforms and their consequences on the psychophysical well-being of children and adolescents.

El uso inapropiado de dispositivos electrónicos puede afectar la salud psicofísica de niños y adolescentes. Por ello, es fundamental acompañarlos y fomentar la alfabetización mediática para garantizar un uso saludable y responsable de la tecnología. En ocasiones que dependen de un complejo multifactorial, el uso inadecuado de las redes puede desencadenar consumos problemáticos y afectar gravemente la vida de los jóvenes. En 2022, la Organización Mundial de la Salud reconoció, a través del CIE 11, la adicción a los videojuegos y utilizó el término "uso problemático" para internet y redes sociales. Este artículo intenta actualizar a los profesionales sobre las nuevas tendencias en el consumo de las redes sociales, los videojuegos, las plataformas de apuestas en línea y sus consecuencias en el bienestar psicofísico de los niños y adolescentes.

RESUMO

El estudio tuvo por finalidad explicar de qué manera se correlaciona la ejecución de gasto público y la fuente de financiamiento de la Dirección de Red de Salud Yunguyo del periodo 2013 al 2023, Perú. Se optó por un diseño metodológico no experimental, longitudinal, cuantitativo y contraste Rho de Spearman. Los resultados identificaron que la ejecución de gasto público se correlaciona significativa y positivamente con la fuente de financiamiento por recursos ordinarios [rho (11) =0.77; p < 0.001], con la fuente de financiamiento por recursos directamente recaudados [rho (11) =0.83; p < 0.001] y, con la fuente de financiamiento por recursos determinados [rho (11) =0.74; p < 0.001]. Se concluye que, ejecutar eficazmente las intervenciones priorizadas por la Dirección de Red de Salud Yunguyo están ligadas a los lineamientos del Presupuesto Público y normatividad del sector con transparencia.

The purpose of the study was to explain how the execution of public spending and the source of financing of the Yunguyo Health Network Directorate are correlated from the period 2013 to 2023, Peru. A non-experimental, longitudinal, quantitative methodological design and Spearman's Rho contrast was chosen. The results identified that the execution of public spending is significantly and positively correlated with the source of financing through ordinary resources [rho (11) =0.77; p < 0.001], with the source of financing being directly raised resources [rho (11) =0.83; p < 0.001], and with the source of financing for determined resources [rho (11) =0.74; p < 0.001]. It is concluded that, effectively executing the interventions prioritized by the Yunguyo Health Network Directorate are linked to the guidelines of the Public Budget and regulations of the sector with transparency

O objetivo do estudo foi explicar como a execução dos gastos públicos e a fonte de financiamento da Diretoria da Rede de Saúde Yunguyo estão correlacionadas no período de 2013 a 2023, Peru. Optou-se por um desenho metodológico não experimental, longitudinal, quantitativo e contraste Rho de Spearman. Os resultados identificaram que a execução dos gastos públicos está significativa e positivamente correlacionada com a fonte de financiamento através de recursos ordinários [rho (11) =0,77; p < 0,001], sendo a fonte de financiamento recursos captados diretamente [rho (11) =0,83; p < 0,001], e com a fonte de financiamento de determinados recursos [rho (11) =0,74; p < 0,001]. Conclui-se que a execução eficaz das intervenções priorizadas pela Direção da Rede de Saúde Yunguyo está vinculada às diretrizes do Orçamento Público e à regulamentação do setor com transparência

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RESUMO

Las redes sociales, al influir en las interacciones diarias y en la gestión de la información, emergen como un factor determinante en la estabilidad psíquica y afectiva de los individuos. Objetivo: Determinar la relación de la adicción a las redes sociales en la salud mental de los estudiantes de medicina humana en una universidad peruana. Material y métodos: Estudio cuantitativo, correlacional, transversal y analítico en el que colaboraron 172 educandos, 82 féminas y 90 varones. Se aplicó el cuestionario Adición a las Redes Sociales diseñado por Escurra y Salas el cual constó de 24 preguntas evaluadas mediante escala de Likert, el mismo fue validado con un Alfa de Cronbach de 0.94. Además, se utilizó el Cuestionario DASS-21 el cual consta de 21 ítems, subdividido en 3 subescalas: depresión, ansiedad y estrés y ha sido validado con un Alfa de Cronbach de 0.96. Resultados: 46.3% de los educandos presentó adicción en nivel medio y alto a las redes sociales. Se halló una correlación significativa entre la ansiedad, el estrés y la adicción a las redes sociales, aunque no se encontró una conexión relevante entre esta última y la depresión. Conclusión: La adicción a las redes sociales impacta negativamente en la salud mental de los educandos, generando niveles elevados de ansiedad y estrés

Social networks, by influencing daily interactions and information management, emerge as a determining factor in the psychic and affective stability of individuals. Objective: To determine the relationship of social media addiction in the mental health of human medicine students at a Peruvian university. Material and methods: Quantitative, correlational, cross-sectional and analytical study in which 172 students, 82 females and 90 males, collaborated. The questionnaire Addition to Social Networks designed by Escurra and Salas was applied which consisted of 24 questions evaluated by Likert scale, it was validated with a Cronbach's Alpha of 0.94. In addition, the DASS-21 Questionnaire was used, which consists of 21 items, subdivided into 3 subscales: depression, anxiety and stress and has been validated with a Cronbach's Alpha of 0.96. Results: 46.3% of the students presented addiction at medium and high level to social networks. A significant correlation was found between anxiety, stress and social media addiction, although no relevant connection was found between the latter and depression. Conclusion: Addiction to social networks negatively impacts on the mental health of students, generating high levels of anxiety and stress

As redes sociais, influenciando as interações diárias e a gestão da informação, emergem como um fator determinante na estabilidade psíquica e afetiva dos indivíduos. Objetivo: Determinar a relação do vício em redes sociais na saúde mental de estudantes de medicina humana em uma Universidade peruana. Material e métodos: estudo quantitativo, correlacional, transversal e analítico no qual colaboraram 172 educandos, 82 mulheres e 90 homens. Aplicou-se o questionário adenda às Redes sociais desenhado por escorra e Salas o qual consistiu de 24 perguntas avaliadas mediante escala de Likert, o mesmo foi validado com um Alfa de Cronbach de 0,94. Além disso, utilizou-se o questionário DASS-21 que consta de 21 itens, subdividido em 3 subescalas: depressão, ansiedade e estresse e foi validado com um Alfa de Cronbach de 0,96. Resultados: 46,3% dos educandos apresentaram dependência em nível médio e alto às redes sociais. Foi encontrada uma correlação significativa entre a ansiedade, o estresse e o vício em redes sociais, embora não tenha sido encontrada uma conexão relevante entre esta última e a depressão. Conclusão: o vício em redes sociais impacta negativamente na saúde mental dos educandos, gerando níveis elevados de ansiedade e estresse

Assuntos

RESUMO

El estudio tuvo por finalidad explicar de qué manera se correlaciona la ejecución de gasto público y la fuente de financiamiento de la Dirección de Red de Salud Yunguyo del periodo 2013 al 2023, Perú. Se optó por un diseño metodológico no experimental, longitudinal, cuantitativo y contraste Rho de Spearman. Los resultados identificaron que la ejecución de gasto público se correlaciona significativa y positivamente con la fuente de financiamiento por recursos ordinarios [rho (11)=0.77; p < 0,001], con la fuente de financiamiento por recursos directamente recaudados [rho (11)=0.83; p < 0,001] y, con la fuente de financiamiento por recursos determinados [rho (11)=0.74; p < 0,001]. Se concluye que, ejecutar eficazmente las intervenciones priorizadas por la Dirección de Red de Salud Yunguyo están ligadas a los lineamientos del Presupuesto Público y normatividad del sector con transparencia.

The purpose of the study was to explain how the execution of public spending and the source of financing of the Yunguyo Health Network Directorate are correlated from the period 2013 to 2023, Peru. A non-experimental, longitudinal, quantitative methodological design and Spearman's Rho contrast was chosen. The results identified that the execution of public spending is significantly and positively correlated with the source of financing through ordinary resources [rho (11) =0.77; p < 0.001], with the source of financing being directly raised resources [rho (11) =0.83; p < 0.001], and with the source of financing for determined resources [rho (11) =0.74; p < 0.001]. It is concluded that, effectively executing the interventions prioritized by the Yunguyo Health Network Directorate are linked to the guidelines of the Public Budget and regulations of the sector with transparency.

O objetivo do estudo foi explicar como a execução dos gastos públicos e a fonte de financiamento da Diretoria da Rede de Saúde Yunguyo estão correlacionadas no período de 2013 a 2023, Peru. Optou-se por um desenho metodológico não experimental, longitudinal, quantitativo e contraste Rho de Spearman. Os resultados identificaram que a execução dos gastos públicos está significativa e positivamente correlacionada com a fonte de financiamento através de recursos ordinários [rho (11) =0,77; p < 0,001], sendo a fonte de financiamento recursos captados diretamente [rho (11) =0,83; p < 0,001], e com a fonte de financiamento de determinados recursos [rho (11) =0,74; p < 0,001]. Conclui-se que a execução eficaz das intervenções priorizadas pela Direção da Rede de Saúde Yunguyo está vinculada às diretrizes do Orçamento Público e à regulamentação do setor com transparência.

RESUMO

Las redes sociales, al influir en las interacciones diarias y en la gestión de la información, emergen como un factor determinante en la estabilidad psíquica y afectiva de los individuos. Objetivo: Determinar la relación de la adicción a las redes sociales en la salud mental de los estudiantes de medicina humana en una universidad peruana. Material y métodos: Estudio cuantitativo, correlacional, transversal y analítico en el que colaboraron 172 educandos, 82 féminas y 90 varones. Se aplicó el cuestionario Adición a las Redes Sociales diseñado por Escurra y Salas el cual constó de 24 preguntas evaluadas mediante escala de Likert, el mismo fue validado con un Alfa de Cronbach de 0.94. Además, se utilizó el Cuestionario DASS-21 el cual consta de 21 ítems, subdividido en 3 subescalas: depresión, ansiedad y estrés y ha sido validado con un Alfa de Cronbach de 0.96. Resultados: 46.3% de los educandos presentó adicción en nivel medio y alto a las redes sociales. Se halló una correlación significativa entre la ansiedad, el estrés y la adicción a las redes sociales, aunque no se encontró una conexión relevante entre esta última y la depresión. Conclusión: La adicción a las redes sociales impacta negativamente en la salud mental de los educandos, generando niveles elevados de ansiedad y estrés.

Social networks, by influencing daily interactions and information management, emerge as a determining factor in the psychic and affective stability of individuals. Objective: To determine the relationship of social media addiction in the mental health of human medicine students at a Peruvian university. Material and methods: Quantitative, correlational, cross-sectional and analytical study in which 172 students, 82 females and 90 males, collaborated. The questionnaire Addition to Social Networks designed by Escurra and Salas was applied which consisted of 24 questions evaluated by Likert scale, it was validated with a Cronbach's Alpha of 0.94. In addition, the DASS-21 Questionnaire was used, which consists of 21 items, subdivided into 3 subscales: depression, anxiety and stress and has been validated with a Cronbach's Alpha of 0.96. Results: 46.3% of the students presented addiction at medium and high level to social networks. A significant correlation was found between anxiety, stress and social media addiction, although no relevant connection was found between the latter and depression. Conclusion: Addiction to social networks negatively impacts on the mental health of students, generating high levels of anxiety and stress.

As redes sociais, influenciando as interações diárias e a gestão da informação, emergem como um fator determinante na estabilidade psíquica e afetiva dos indivíduos. Objetivo: Determinar a relação do vício em redes sociais na saúde mental de estudantes de medicina humana em uma Universidade peruana. Material e métodos: estudo quantitativo, correlacional, transversal e analítico no qual colaboraram 172 educandos, 82 mulheres e 90 homens. Aplicou-se o questionário adenda às Redes sociais desenhado por escorra e Salas o qual consistiu de 24 perguntas avaliadas mediante escala de Likert, o mesmo foi validado com um Alfa de Cronbach de 0,94. Além disso, utilizou-se o questionário DASS-21 que consta de 21 itens, subdividido em 3 subescalas: depressão, ansiedade e estresse e foi validado com um Alfa de Cronbach de 0,96. Resultados: 46,3% dos educandos apresentaram dependência em nível médio e alto às redes sociais. Foi encontrada uma correlação significativa entre a ansiedade, o estresse e o vício em redes sociais, embora não tenha sido encontrada uma conexão relevante entre esta última e a depressão. Conclusão: o vício em redes sociais impacta negativamente na saúde mental dos educandos, gerando níveis elevados de ansiedade e estresse.

RESUMO

INTRODUCTION: Despite the availability of around 30 antiseizure medications, 1/3 of patients with epilepsy fail to become seizure-free upon pharmacological treatment. Available medications provide adequate symptomatic control in two-thirds of patients, but disease-modifying drugs are still scarce. Recently, though, new paradigms have been explored. AREAS COVERED: Three areas are reviewed in which a high degree of innovation in the search for novel antiseizure and antiepileptogenic medications has been implemented: development of novel screening approaches, search for novel therapeutic targets, and adoption of new drug discovery paradigms aligned with a systems pharmacology perspective. EXPERT OPINION: In the past, worldwide leaders in epilepsy have reiteratively stated that the lack of progress in the field may be explained by the recurrent use of the same molecular targets and screening procedures to identify novel medications. This landscape has changed recently, as reflected by the new Epilepsy Therapy Screening Program and the introduction of many in vitro and in vivo models that could possibly improve our chances of identifying first-in-class medications that may control drug-resistant epilepsy or modify the course of disease. Other milestones include the study of new molecular targets for disease-modifying drugs and exploration of a systems pharmacology perspective to design new drugs.

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Cybersecurity has become a central concern in the contemporary digital era due to the exponential increase in cyber threats. These threats, ranging from simple malware to advanced persistent attacks, put individuals and organizations at risk. This study explores the potential of artificial intelligence to detect anomalies in network traffic in a university environment. The effectiveness of automatic detection of unconventional activities was evaluated through extensive simulations and advanced artificial intelligence models. In addition, the importance of cybersecurity awareness and education is highlighted, introducing CyberEduPlatform, a tool designed to improve users' cyber awareness. The results indicate that, while AI models show high precision in detecting anomalies, complementary education and awareness play a crucial role in fortifying the first lines of defense against cyber threats. This research highlights the need for an integrated approach to cybersecurity, combining advanced technological solutions with robust educational strategies.