RESUMO

Renal hyperparathyroidism stands out among the complications of kidney disease in dogs due to phosphorus retention with a predisposition to hypocalcemia, parathyroid hormone stimulation with mobilization of calcium from the bones, characterizing fibrous osteodystrophy, unusual in the elderly. The objective was to report it in 12-year-old Labrador with polyuria, polydipsia, and emesis for five months due to maxillary and mandibular volume increase, followed by loosely fixed teeth, and facial deformity. Blood tests showed anemia, thrombocytosis, azotemia, hypoalbuminemia and hyperphosphatemia and urinalysis showed low density, glycosuria, proteinuria, and moderate caudate and transitional epithelial cells. Oral x-rays showed loss of dental bone support and decreased bone radiopacity. Chest radiographs showed decreased density in the ribs and costochondral junction; on the other hand, organs of the cardiorespiratory system showed no changes. The electrocardiogram and echocardiogram did not show impairment. Abdominal ultrasound revealed kidneys with asymmetry, increased echogenicity of the cortical and poorly preserved cortico-medullary definition. Oral histopathology showed intense fibroplasia associated with bone reabsorption. Support therapy was instituted, but the patient died ten days after consultation. Thus, although uncommon in the elderly, fibrous osteodystrophy should be investigated in dogs with advanced-stage chronic kidney disease and, even with conservative therapies, the prognosis is unfavorable.

O hiperparatireoidismo renal destaca-se entre as complicações da doença renal em cães, pela retenção de fósforo com predisposição à hipocalcemia, estimulação de paratormônio com mobilização do cálcio dos ossos, caracterizando a osteodistrofia fibrosa, incomum em idosos. O objetivo foi relatá-la em Labrador de 12 anos com poliúria, polidipsia e vômitos há cinco meses, além de aumento de volume maxilar e mandibular seguido de dentes frouxamente fixados e deformidade facial. Os exames sanguíneos denotaram anemia, trombocitose, azotemia, hipoalbuminemia, hiperfosfatemia, urinálise, baixa densidade, glicosúria, proteinúria e moderadas células caudadas e epiteliais de transição. Pelos raios X orais, houve perda da sustentação óssea dentária e diminuição da radiopacidade óssea. As radiografias de tórax demonstraram diminuição da densidade óssea na região dos arcos costais e junção costocondral; em contrapartida, órgãos do sistema cardiorrespiratório se mostraram sem alterações aparentes. O eletrocardiograma e o ecocardiograma não incidiram comprometimento. O ultrassom abdominal revelou rins com assimetria, aumento da ecogenicidade cortical e definição corticomedular pouco preservada, e a histopatologia oral apontou intensa fibroplasia associada à reabsorção óssea. Foi instituída terapia suporte, mas o paciente veio a óbito 10 dias após a consulta. Assim, mesmo que incomum em idosos, a osteodistrofia fibrosa deve ser investigada em cães com doença renal crônica em estágio avançado, mesmo com as terapias conservadoras, o prognóstico é desfavorável.

Assuntos

RESUMO

Background: Cases of renal fibrous osteodystrophy are usually associated with nutritional causes, which of renal causesare considered uncommon in dogs. This disorder is characterized by the intense proliferation of fibrous connective tissue inbones, impairing bone stiffness. The aim of this study was to report a case of fibrous osteodystrophy secondary to chronickidney disease in a canine with a “rubber jaw” facial deformity.Case: A 4-year-old male unneutered mongrel dog weighing 5.2 kg had a history of apathy, progressive weight loss andvomiting for one month, and polyuria and polydipsia for more than three months. In addition, the owner complained aboutthe deformed appearance in the muzzle region of the animal, which was evidenced flexibility of the same, with a displacement of the mandible and maxilla on physical examination, similar to the “rubber jaw”. Blood tests revealed macrocyticanemia, elevated total plasma proteins, and lymphopenia-associated neutrophilia, as well as hyperphosphatemia (24 mg/dL), uremia (283.6 mg/dL) and increased creatinine (8.6 mg/dL), ALT (143.2 UI/L) and alkaline phosphatase (3222.2UI/L), while calcium (8.8 mg/dL) and albumin (1.9 g/dL) were decreased. A serological test for visceral leishmaniasis wasalso performed, which was negative. Abdominal ultrasound imaging revealed kidneys with alterations in tissue architecture, increased thickness and complete loss of cortico-medullary relationship, while the parathyroid gland was enlargedand spindle-shaped. Cranial radiography showed marked radiopacity of the bilateral maxillary bones, with destructionof the nasal, turbinate and frontal bones, as well as loosening of the teeth and destruction of the mandibular bone matrix,characterizing an aspect of “rubber jaw”. Based on the history, history and evidence of azotemia, hyperphosphatemia andloss of facial bone density, the diagnosis of fibrous osteodystrophy secondary to chronic kidney...(AU)

Assuntos

RESUMO

Background: Cases of renal fibrous osteodystrophy are usually associated with nutritional causes, which of renal causesare considered uncommon in dogs. This disorder is characterized by the intense proliferation of fibrous connective tissue inbones, impairing bone stiffness. The aim of this study was to report a case of fibrous osteodystrophy secondary to chronickidney disease in a canine with a “rubber jaw” facial deformity.Case: A 4-year-old male unneutered mongrel dog weighing 5.2 kg had a history of apathy, progressive weight loss andvomiting for one month, and polyuria and polydipsia for more than three months. In addition, the owner complained aboutthe deformed appearance in the muzzle region of the animal, which was evidenced flexibility of the same, with a displacement of the mandible and maxilla on physical examination, similar to the “rubber jaw”. Blood tests revealed macrocyticanemia, elevated total plasma proteins, and lymphopenia-associated neutrophilia, as well as hyperphosphatemia (24 mg/dL), uremia (283.6 mg/dL) and increased creatinine (8.6 mg/dL), ALT (143.2 UI/L) and alkaline phosphatase (3222.2UI/L), while calcium (8.8 mg/dL) and albumin (1.9 g/dL) were decreased. A serological test for visceral leishmaniasis wasalso performed, which was negative. Abdominal ultrasound imaging revealed kidneys with alterations in tissue architecture, increased thickness and complete loss of cortico-medullary relationship, while the parathyroid gland was enlargedand spindle-shaped. Cranial radiography showed marked radiopacity of the bilateral maxillary bones, with destructionof the nasal, turbinate and frontal bones, as well as loosening of the teeth and destruction of the mandibular bone matrix,characterizing an aspect of “rubber jaw”. Based on the history, history and evidence of azotemia, hyperphosphatemia andloss of facial bone density, the diagnosis of fibrous osteodystrophy secondary to chronic kidney...

Assuntos

RESUMO

A insuficiência renal crônica em estágios mais avançados leva ao desenvolvimento de hiperparatireoidismo renal secundário. Essa doença é raramente observada em cães jovens e sem raça definida. Os animais acometidos geralmente apresentam poliúria, polidispsia, letargia, perda de peso, vômitos, halitose, ulcerações em cavidade oral, mucosas pálidas e em alguns casos, deformidade facial, mais conhecida como “mandíbula de borracha”, sendo que essa última alteração não é comumente observada nos animais idosos. Para a confirmação dessa doença é necessário realização de exames laboratoriais como hemograma, bioquímica e urinálise, além de exames de imagem, como ultra-sonografia e radiografia do crânio. O tempo de sobrevida do animal depende da precocidade do diagnóstico e o tratamento instituído é o conservativo, de suporte e sintomático. O objetivo desse artigo foi relatar o caso de uma cadela de meia-idade com hiperparatireoidismo renal secundário apresentando “mandíbula de borracha”, atendida no Hospital Veterinário de Uberaba

The chronic renal failure in later stages leads to the development of renal secondary hyperparathyroidism. This disease is rarely observed in young dogs and cross-breeds. Affected animals presents polyuria, polydipsia, lethargy, vomiting, weight loss, halitosis, ulcerations in oral cavity, pale and in some cases facial deformity commonly referred to as “rubber jaw”, being that this last change is not commonly observed in older animals. For confirmation of such disease are necessary laboratory examinations as CBC, biochemistry and urinalysis parameters, as well examinations of image, such as ultrasound and x-ray skull. Survival of the animal depends on the precocity of the diagnosis and treatment usually is conservative, support and symptomatic. The purpose of this article was to report the case of a bitch middle-age with renal secondary hyperparathyroidism presenting “rubber jaw”, admitted in the Veterinary Hospital of Uberaba

Assuntos

RESUMO

A insuficiência renal crônica em estágios mais avançados leva ao desenvolvimento de hiperparatireoidismo renal secundário. Essa doença é raramente observada em cães jovens e sem raça definida. Os animais acometidos geralmente apresentam poliúria, polidispsia, letargia, perda de peso, vômitos, halitose, ulcerações em cavidade oral, mucosas pálidas e em alguns casos, deformidade facial, mais conhecida como “mandíbula de borracha”, sendo que essa última alteração não é comumente observada nos animais idosos. Para a confirmação dessa doença é necessário realização de exames laboratoriais como hemograma, bioquímica e urinálise, além de exames de imagem, como ultra-sonografia e radiografia do crânio. O tempo de sobrevida do animal depende da precocidade do diagnóstico e o tratamento instituído é o conservativo, de suporte e sintomático. O objetivo desse artigo foi relatar o caso de uma cadela de meia-idade com hiperparatireoidismo renal secundário apresentando “mandíbula de borracha”, atendida no Hospital Veterinário de Uberaba(AU)

The chronic renal failure in later stages leads to the development of renal secondary hyperparathyroidism. This disease is rarely observed in young dogs and cross-breeds. Affected animals presents polyuria, polydipsia, lethargy, vomiting, weight loss, halitosis, ulcerations in oral cavity, pale and in some cases facial deformity commonly referred to as “rubber jaw”, being that this last change is not commonly observed in older animals. For confirmation of such disease are necessary laboratory examinations as CBC, biochemistry and urinalysis parameters, as well examinations of image, such as ultrasound and x-ray skull. Survival of the animal depends on the precocity of the diagnosis and treatment usually is conservative, support and symptomatic. The purpose of this article was to report the case of a bitch middle-age with renal secondary hyperparathyroidism presenting “rubber jaw”, admitted in the Veterinary Hospital of Uberaba(AU)

Assuntos