RESUMO
BACKGROUND: Perillyl alcohol (POH) is a monoterpenoid found in plant essential oils and has been shown to relax murine vessels, but its effect on human vessels remains poorly studied. OBJECTIVE: The study aimed to characterize the effect of POH on human umbilical arteries (HUA). METHODS: Rings of HUA were obtained from uncomplicated patients and suspended in an organ bath for isometric recording. The vasorelaxant effect of POH in HUA was evaluated on basal tone and electromechanical or pharmacomechanical contractions, and possible mechanisms of action were also investigated. RESULTS: POH (1-1000 µM) altered the basal tone of HUA and completely relaxed HUA rings precontracted with KCl (60 mM) or 5-HT (10 µM), obtaining greater potency in the pharmacomechanical pathway (EC50 110.1 µM), suggesting a complex interference in the mobilization of extra- and intracellular Ca2+. POH (1000 µM) inhibited contractions induced by BaCl2 (0.1-30 mM) in a similar way to nifedipine (10 µM), indicating a possible blockade of L-type VOCC. In the presence of potassium channel blockers, tetraethylammonium (1 mM), 4-aminopyridine (1 mM), or glibenclamide (10 µM), an increase in the EC50 value of the POH was observed, suggesting a modulation of the activity of BKCa, KV, and KATP channels. CONCLUSION: The data from this study suggest that POH modulates Ca2+ and K+ ion channels to induce a relaxant response in HUA.
RESUMO
ABSTRACT Parkinson's disease is a neurodegenerative disorder predominantly resulting from dopamine depletion in the substantia nigra pars compacta. Some psychiatric disorders may have dopaminergic dysfunction as their substrate. We describe a well-documented case of Parkinson's disease associated with Bipolar Disorder. Although there is some knowledge about the association between these diseases, little is known about its pathophysiology and correlation. We believe that among various hypotheses, many neurotransmitters are linked to this pathophysiology.
RESUMO A doença de Parkinson é um distúrbio neurodegenerativo resultante predominantemente da depleção de dopamina na substância negra pars compacta. Alguns transtornos psiquiátricos podem ter como substrato a disfunção dopaminérgica. Nós descrevemos um caso bem documentado de doença de Parkinson associado a Transtorno Bipolar. Embora haja algum conhecimento sobre a associação entre essas doenças, pouco se sabe sobre sua fisiopatologia e correlação. Acreditamos que dentre várias hipóteses, muitos neurotransmissores estão ligados a esta fisiopatologia.
Assuntos
Humanos , Doença de Parkinson , Transtorno Bipolar , Dopamina , Neurônios SerotoninérgicosRESUMO
Parkinson's disease is a neurodegenerative disorder predominantly resulting from dopamine depletion in the substantia nigra pars compacta. Some psychiatric disorders may have dopaminergic dysfunction as their substrate. We describe a well-documented case of Parkinson's disease associated with Bipolar Disorder. Although there is some knowledge about the association between these diseases, little is known about its pathophysiology and correlation. We believe that among various hypotheses, many neurotransmitters are linked to this pathophysiology.
A doença de Parkinson é um distúrbio neurodegenerativo resultante predominantemente da depleção de dopamina na substância negra pars compacta. Alguns transtornos psiquiátricos podem ter como substrato a disfunção dopaminérgica. Nós descrevemos um caso bem documentado de doença de Parkinson associado a Transtorno Bipolar. Embora haja algum conhecimento sobre a associação entre essas doenças, pouco se sabe sobre sua fisiopatologia e correlação. Acreditamos que dentre várias hipóteses, muitos neurotransmissores estão ligados a esta fisiopatologia.