RESUMO
Eight patients with severe glomerulonephritis and an average inulin clearance of 21.7 ml/min/1.73 m2 body surface were treated with high-dosage intravenous methylprednisolone, 30 mg/kg given over a one-hour period on each of six alternate days. The mean inulin clearance rate doubled after this "pulse" therapy. In the six patients treated early in the course of their disease, GFR increased to a mean of 100.2 ml/min/1.73 m2 during the follow-up period extending for up to three years and was accompanied by clinical improvement. These observations suggest that "pulse" methylprednisolone may be beneficial in treating some patients with potentially life-threatening severe glomerulonephritis.
Assuntos
Glomerulonefrite/tratamento farmacológico , Metilprednisolona/administração & dosagem , Adolescente , Ácidos Aminoipúricos , Criança , Pré-Escolar , Feminino , Glomerulonefrite/diagnóstico , Humanos , Infusões Parenterais , Inulina , Testes de Função Renal , Masculino , Metilprednisolona/uso terapêuticoRESUMO
Clearances of inulin and para-aminohippuric acid were performed in 22 newborn infants without renal disease. Ages varied from 12 hours to 25 days. The mean values of inulin and PAH clearances during the first four days of life were 10.8 +/- 1.0 ml/min/m2 and 30.8 +/- ml/min/m2, respectively. A twofold increase in glomerular filtration rate was observed during the first 14 days of life. A similar increase in PAH clearance occurred during this period. No correlation was found between gestational age (range: 32 to 39 weeks) and GFR in ten neonates studied during the first four days after birth.