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Aconitum napellus L. is a popular medicinal plant extensively used in homeopathy. This article provides detailed morphology and microscopy, including the anatomical and histochemical features of the herb, to aid authentication and quality control. In cross-section, the root in secondary growth shows the phloem surrounded by pericyclic fibers and a well-developed xylem. The stem is irregular in outline, displaying unicellular trichomes and many free collateral vascular bundles encircling the pith. The leaf is dorsiventral, hypostomatic with anomocytic and anisocytic stomata, and shows non-glandular trichomes. The floral parts are characterized by uniseriate epidermises, homogeneous mesophyll, anomocytic stomata on the abaxial surface, trichomes, and oval pollen grains. The tissue fragments in powdered herbs show these characteristics and have numerous starch grains with thimble-shaped, linear or star-shaped hilum. The detailed macroscopic and microscopic analysis provided in this study can help in the authentication and quality control of A. napellus raw materials. RESEARCH HIGHLIGHTS: Key anatomical, micromorphological, and microchemical features of Aconitum napellus are described. The results of the study can support the taxonomy of the genus Aconitum. Morphological standardization of the species reported here is helpful in the quality control of this herb.

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A Homeopatia é uma das ciências médicas complementares mais utilizadas para pacientes com Câncer, sendo também utilizada durante o tratamento de crianças com a referida moléstia, havendo relato e debate de seu uso na literatura médica. Visando construir o conhecimento e dividir experiências, relatamos seis casos de crianças e adolescentes com câncer, para os quais realizamos tratamento homeopático, em nossa experiência na cidade de São Paulo. Além da diversidade de sexos e idade, os casos apresentam diagnósticos oncológicos diferentes, bem como momentos diferentes no tratamento, sendo curativo ou paliativo, e os medicamentos homeopáticos, baseados tanto na totalidade sintomática característica quanto no modo reacional para cada indivíduo, puderam ser utilizados para todos com satisfação de famílias e pacientes, mesmo quando o desfecho letal foi a via final no estado paliativo. Assim, a Homeopatia pode também ser prescrita para os casos oncológicos infantis como terapia complementar ao tratamento convencional, sendo a pesquisa neste campo vasta e possível.

Homeopathy is one of the most used complementary medical sciences for cancer patients, and is also used duringtreatment of children with the aforementioned disease, with reports and debate of its use in medical literature. Aiming to build knowledge and sharing experiences, we report six cases of children and adolescents with cancer, for which we carry out homeopathic treatment, in our experience in the city of São Paulo. In addition to the diversity of sexes and age, the cases present different oncological diagnoses, as well as as different moments in the treatment, being curative or palliative, and homeopathic medicines, based both on symptomatic totality characteristic and in the reactional mode for each individual, could be used for everyone with the satisfaction of families and patients, even when the lethal outcome was the final route in the palliative state. Therefore, Homeopathy can also be prescribed for oncological cases children as complementary therapy to conventional treatment, research in this field is vast and possible.

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Seven new diterpenoid alkaloids, acotarines A-G (1-7), along with four known diterpenoid alkaloids, were isolated from Aconitum taronense. Their structures were established by 1D, 2D NMR spectra and HRESIMS data. Acotarine A (1) represents a franchetine-type alkaloid characterized by a N-butanone moiety. All the compounds were tested for their activities to induce lysosomal biogenesis through LysoTracker Red staining, compounds acotarines B (2), E (5), F (6), indaconitine (8), 7,8-epoxy-franchetine (9), and 6-epiforesticine (10) showed inducing lysosomal biogenesis activity.

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BackgroundAnxiety disorders are highly prevalent that affect millions of people worldwide. Homeopathic system is gaining popularity due to its efficacy in chronic diseases. Ultra-diluted Aconitum napellusis a homeopathic medicine used by clinicians for treatment ofacute anxiety.AimObjective of this study is to test the efficacy of Aconiteon experimental anxiety models of Wistar rats. Methodology18 Female Wistar rats were dividedinto Control, Anxiety, andAnxiety + Aconite(ANX+ACO) groups. Acute stress was induced by restraining the rats for sixhours daily for fivedays in Anxiety and ANX + ACO groups. After fivedays of stress,a single dose of Aconite200cH was given to ANX + ACO group through oral gavage, whereas control and anxiety group rats were maintainedwith a normaldiet. Following this, behavioral assessment was done. Histological sections of the hippocampal area weretaken and stained with Hematoxylin and Eosin and also Cresyl violet stain. ResultsIt was observedthat the Aconitetreated group had morenumber of entries and also the percentage of time spent in the open arm was higher than the stressed anxiety group. Histological study of the brain tissue procured from all three groups was analyzed. ConclusionIt was inferred that ultra-diluted homeopathicAconitehas decreased anxiety in Wistar rats which were subjectedto acute restrainstress. However,the decrease was not statistically significant to deduce Aconiteas an anxiolytic.(AU)

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A febre é um sinal clínico muito associado à infecção, gerando grande número de atendimentos em emergências e consultórios, e uso indiscriminado de antipiréticos.É desencadeada pela ação de citocinas pirogênicas endógenas e exógenas, desempenhando funções protetoras no organismo e auxiliando na recuperação. Conhecendo a importância da febre no mecanismo imunológico, e com a intenção de aliviar o desconforto do paciente, o medicamento homeopático tem como finalidade restabelecer a força vital, acelerando o processo de cura. Dentre todos os medicamentos homeopáticos, o simillimum é encontrado através da totalidade sintomática do paciente.Neste trabalho listamos alguns dos principais medicamentos utilizados para o tratamento da febre e suas indicações.(AU)

Fever is a clinical symptom generally associated to infection, generating a large number of emergency cases and medical appointments, and an indiscriminate use of antipyretics. The fever is triggered by the action of endogenous and exogenous pyrogenic cytokines, performing protective functions in the organism and aiding in the recovery. Regarding the importance of the fever in the immune mechanism, and with the intent to relieve the discomfort of the patient, the homeopathic medicine aims to restore the vital force, accelerating the healing process. Among all homeopathic medicines, simillimum is found through totality of symptoms manifested by the patient.(AU)

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We used next-generation sequencing to develop 9 novel microsatellite markers in Aconitum austrokoreense, an endemic and endangered medicinal plant in Korea. Owing to its very limited distribution, over-harvesting for traditional medicinal purposes, and habitat loss, the natural populations are dramatically declining in Korea. All novel microsatellite markers were successfully genotyped using 64 samples from two populations (Mt. Choejeong, Gyeongsangbuk-do and Ungseokbong, Gyeongsangnam-do) of Gyeongsang Province. The number of alleles ranged from 2 to 7 per locus in each population. Observed and expected heterozygosities ranged from 0.031 to 0.938 and from 0.031 to 0.697, respectively. The novel markers will be valuable tools for assessing the genetic diversity of A. austrokoreense and for germplasm conservation of this endangered species.

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Objetivos: Realizar uma breve revisão da literatura a respeito da sintomatologia associada à erupção dental, a fim de chamar a atenção dos profissionais da saúde que prestam atendimento a crianças para o desenvolvimento dos trabalhos de pesquisa nesta área. Fonte pesquisadas: livre escolha de artigos pertinentes da literatura relacionados ao processo de erupção dental e sintomatologias associadas. Síntese dos dados: é comum que os pais e profissionais da saúde relatem que o processo de erupção dos dentes decíduos pode estar associado a alterações locais e sistêmicas. Embora as alterações locais como edema, eritema e prurido gengival estejam diretametne ligados à erupção dental, outros fatores sistêmicos de ordem geral, como febre, irritabilidade, perda do sono e apetite e até mesmo convulsões não estão claramente associados. Realizada a descrição da matéria médica homeopática dos principais medicamentos utilizados, a fim de minimizar os sintomas descritos acima. Conclusão: a erupção dos dentes decíduos e os possíveis efeitos do processo de erupção dental na saúde infantil tá muitos anos e crenças tradicionais sobre o assunto ainda não foram inteiramente embasadas por achados científicos. (AU)

Objectives: to carry out a brief review of the literature about the symptomatology associated to dental eruption in order to call the attention of health professionals assisting children to the development of research works in this field. Researched sources: free choice of pertinent literature articles related to the dental eruption process and associated symptomatologies. Data syntheses: it is common that parents and health professionals report that the deciduos teeth eruption process may be associated to local and systemic alterations. Although local alterations such as edema, erytema and gum pruritus are directly relatead to dental eruption, other general systemic factors such as fever, irritability, sleeplessness and lack of appetite, and even seizures, are not clearly associated to it. The knowledge of classic works described in the literature consulted in this review is important t guide health professionals to develop new researches in this field. It was done a description of main homeopathic medicines to minimize all this symptoms. Conclusion: deciduos teeth eruption and the possible effects of the dental eruption process in the child’s health have been debated for many years, and tradicional beliefs about the matter were still not entirely based on scientific findings. (AU)

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Um dos insumos mais utilizados na manufatura de medicamentos homeopáticos é a tintura-mãe. Um método aparentemente útil para o controle de qualidade das tinturas-mães é a análise capilar. Este método analítico, tornado público no início do século passado por Hugo Platz, caiu em desuso após o advento de técnicas cromatográficas mais modernas. Embora empregue técnicas simples e de baixo custo, não há estudos de validação da análise capilar. O presente ensaio teve por objetivo validar o método de análise capilar utilizado no controle de qualidade de tinturas-mãe. Para tanto foram obtidos os espectros capilares das tinturas-mãe de Aconitum napellus L., Strychnos nux vomica L. e Anemone pulsatilla L. provenientes de fornecedores nacionais qualificados pela Associação Brasileira de Farmacêuticos Homeopatas. Os atributos avaliados foram precisão, reprodutibilidade e seletividade. Os resultados alcançados recomendam a utilização do método de análise capilar, conforme proposto por Platz, nas análises qualitativas de tinturas-mãe.

Mother tinctures are one of the most common starting materials used in the elaboration of homeopathic medicines. Capillary analysis seems a useful method for quality control of mother tinctures. This method was publicized in the beginning of the 20th century by Hugo Platz to fell into disuse following the development of the modern chromatographic techniques. Despite the simple techniques involved, and the low cost of the overall method, no studies of validation have yet been performed of Platz´s capillary analysis. The present study sought to validate capillary analysis for quality control of mother tinctures. The capillary spectra of mother tinctures of Aconitum napellus L., Strychos nux vomica L. e Anemone pulsatilla L. provided by Brazilian suppliers certified by the Brazilian Association of Homeopathic Pharmacists were obtained. The attributes evaluated were accuracy, reproducibility and selectivity. The results allow recommending the use of capillary analysis as formulated by Platz for qualitative analysis of mother tinctures.

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