RESUMO
ABSTRACT: Digital papillary adenocarcinoma is a malignant adnexal tumor with a predilection for acral sites. Hidradenoma is a benign solid and cystic sweat gland neoplasm with focal ductal and glandular differentiation and good outcomes. Hidradenomas can occur at acral sites and show papillary structures; for this reason, they are included in the differential diagnosis of digital papillary adenocarcinoma, and immunohistochemistry is a valuable tool in this scenario. We described a case of a 43-year-old man with an epithelial tumor showing papillary structures in the intermediate phalanx of the fourth finger. There was diffuse positivity for p63 and negativity for S100 protein, suggesting that this tumor was an acral hidradenoma with papillary structures.
Assuntos
Acrospiroma , Adenocarcinoma de Células Claras , Adenocarcinoma Papilar , Adenoma de Glândula Sudorípara , Neoplasias Ósseas , Neoplasias da Mama , Carcinoma de Apêndice Cutâneo , Neoplasias Cutâneas , Neoplasias das Glândulas Sudoríparas , Acrospiroma/diagnóstico , Acrospiroma/cirurgia , Adenocarcinoma Papilar/química , Adenocarcinoma Papilar/diagnóstico , Adenocarcinoma Papilar/cirurgia , Adenoma de Glândula Sudorípara/patologia , Adulto , Humanos , Imuno-Histoquímica , Masculino , Proteínas S100 , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Neoplasias das Glândulas Sudoríparas/diagnóstico , Neoplasias das Glândulas Sudoríparas/metabolismo , Neoplasias das Glândulas Sudoríparas/cirurgiaRESUMO
OBJECTIVE: Signet ring carcinoma of the stomach is well known to be more aggressive and infiltrating than adenocarcinoma. Different studies have proposed that signet ring cell carcinoma would be more infiltrating because of the loss of E-cadherin expression, this cadherin is a class of protein cell membrane protein which plays an important role in cell-adhesion. METHODS: We carried out a transversal comparative study, in order to measure the E-cadherin expression in 10 cases of signet ring cell and in 10 cases of adenocarcinoma, with help of immunohistochemistry. RESULTS: We found a bigger expression of E-cadherin in adenocarcinomas (100%) than signet ring cell carcinoma (40%), this difference was significative using Fisher test (p = 0,011). The loss of E-cadherin would explain the bigger infiltrating capacity in comparison to adenocarcinoma.
Assuntos
Adenocarcinoma Papilar/química , Adenocarcinoma/química , Biomarcadores Tumorais/análise , Caderinas/análise , Carcinoma de Células em Anel de Sinete/química , Proteínas de Neoplasias/análise , Neoplasias Gástricas/química , Adenocarcinoma/diagnóstico , Adenocarcinoma/patologia , Adenocarcinoma Papilar/diagnóstico , Adenocarcinoma Papilar/patologia , Idoso , Carcinoma de Células em Anel de Sinete/diagnóstico , Carcinoma de Células em Anel de Sinete/patologia , Adesão Celular , Estudos Transversais , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Neoplasias Gástricas/patologiaRESUMO
The DNA content in gallbladder carcinoma and its relation to histological and cytological features was studied in 79 primary gallbladder carcinomas and 16 metastases. Abnormal DNA content was observed in 48 (51%) of 95 cases. In primary carcinomas, 44 (55.6%) showed a diploid DNA content, and 35 (44.4%) were aneuploid. The majority of the metastatic lesions were aneuploid DNA (81.3%; P = 0.006). Marked differences in the coefficient of variation estimated by manual, Kosugi and Dean methods were detected (P = 0.005). Seventy-one per cent of early gallbladder carcinomas had a normal DNA content. In contrast 54% of the cases with subserosal or serosal infiltration had normal DNA content. In primary tumours the degree of architectural atypia had a close relationship with the degree of cellular atypia (P = 0.00001). Only two (15%) of 13 cases with mild architectural atypia, and 34 (51.5%) of 66 cases with marked architectural atypia were aneuploid. Only one (10%) of 10 cases with mild cellular atypia and 35 (51%) of 69 with high cellular atypia had abnormal DNA content (P = 0.01) The importance of DNA content as a marker in gallbladder carcinoma remains uncertain and its clinical importance requires further clinicopathological studies.
Assuntos
Aneuploidia , DNA de Neoplasias/análise , DNA de Neoplasias/genética , Neoplasias da Vesícula Biliar/química , Neoplasias da Vesícula Biliar/genética , Adenocarcinoma Papilar/química , Adenocarcinoma Papilar/genética , Adenocarcinoma Papilar/patologia , Biomarcadores Tumorais/genética , Diploide , Feminino , Citometria de Fluxo , Neoplasias da Vesícula Biliar/patologia , Humanos , MasculinoRESUMO
Two cases of polymorphous low-grade adenocarcinoma of the papillary type, from minor salivary glands were studied by light microscopy and immunohistochemistry. One case exhibited a predominance of the papillary pattern, whereas the other presented the following patterns of histological appearance: papillary, solid, pseudocystic and tubular. Utilizing the peroxidase-antiperoxidase (PAP) method, the intermediate filament vimentin, keratin and S100 protein were observed in tumor cells. The immunohistochemical analysis revealed two types of neoplastic cells: myoepithelial and luminal.