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1.
Rev. bras. ortop ; 58(5): 750-754, Sept.-Oct. 2023. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1529937

RESUMO

Abstract Objective Hip osteoarthritis (HO) causes pain and deranges functioning. Surgical treatment is the preferred approach in severe cases, but clinical comorbidities, age and the long waiting list may compromise quality of life. This study aimed to describe the results of acupuncture for the control pain and improvement of functioning in subjects with HO. Method Twelve severe HO patients were treated with ten weekly sessions of a standardized acupuncture point protocol. Pain intensity was assessed with the Visual Analog Pain Scale (VAS) and quality of life with WOMAC Index. Results Pain intensity (VAS) reduced from 75.8 ± 18.8 mm to 20.0 ± 22.6 mm after 10 acupuncture sessions and 48.3 ± 26.6mm in the follow-up (ANOVA F = 7.99; p < 0.001). WOMAC Index values reduced from 74.7 ± 12.7 to 45.7 ± 22.1 and 54.6 ± 22.9 at the same timepoints. Conclusion Acupuncture is an effective conservative rehabilitation strategy to reduce pain and improve quality of life in subjects with severe HO.


Resumo Objetivo A osteoartrite (OA) de quadril causa dor e perda da funcionalidade. O tratamento cirúrgico é a procedimento de escolha nos casos graves, mas as comorbidades clínicas, a idade e a longa lista de espera podem comprometer a qualidade de vida. Este estudo teve como objetivo descrever os resultados da acupuntura no controle da dor e melhora da funcionalidade em indivíduos com OA de quadril. Método Doze pacientes com OA de quadril grave foram tratados com dez sessões semanais de um protocolo padronizado de pontos de acupuntura. A intensidade da dor foi avaliada pela Escala Visual Analógica de Dor (EVA) e a qualidade de vida pelo Índice WOMAC. Resultados A intensidade da dor (EVA) reduziu de 75,8 ± 18,8mm para 20,0 ± 22,6mm após 10 sessões de acupuntura e 48,3 ± 26,6mm no período de seguimento (ANOVA F = 7,99; p < 0,001). Os valores do Índice WOMAC reduziram de 74,7 ± 12,7 para 45,7 ± 22,1 e 54,6 ± 22,9 nos mesmos momentos. Conclusão A acupuntura é uma estratégia de reabilitação conservadora eficaz para reduzir a dor e melhorar a qualidade de vida em indivíduos com OA de quadril grave.


Assuntos
Humanos , Qualidade de Vida , Osteoartrite do Quadril/terapia , Analgesia por Acupuntura , Dor Crônica/terapia
2.
Ciênc. Anim. (Impr.) ; 32(3): 18-26, jul.-set. 2022. ilus, tab, graf
Artigo em Português | VETINDEX | ID: biblio-1402286

RESUMO

A castração química é utilizada para castrar cães machos a um custo mais baixo que o procedimento cirúrgico, que é o método mais aplicado para castrar cães e gatos. A castração química é um procedimento mais simples que a castração cirúrgica e pode ser realizada a nível ambulatorial, sem necessidade de anestesia geral. Entretanto, devido ao estresse pela manipulação e ao desconforto produzido pela injeção de uma substância no interior dos testículos, faz-se necessária uma sedação para que a castração química seja efetuada de um modo que proporcione o bem-estar do animal. Assim, este artigo tem como objetivo propor um protocolo inovador para sedação de cães submetidos à castração química. Para isso, foram utilizados 12 cães submetidos à administração de xilazina em subdose no acuponto yin tang. Após o estabelecimento da sedação, os cães foram castrados quimicamente. O protocolo proposto permitiu que a castração química fosse realizada com conforto para o paciente e para a equipe de médicos veterinários. Desta forma, concluiu-se que o protocolo de sedação é seguro e pode ser empregado em cães para procedimentos não invasivos, como exames, coleta de material e outros processos ou técnicas semelhantes.


Chemical castration is used to spay male dogs at a lower cost than the surgical procedure, which is the most applied method to spay dogs and cats. Chemical castration is a simpler procedure than surgical castration and can be performed on an outpatient basis, without the need for general anesthesia. However, due to the stress caused by manipulation and the discomfort produced by the injection of a substance into the testicles, sedation is necessary so that chemical castration is to be carried out in a way that provides the animal's welfare. Thus, this article aims to propose an innovative protocol for sedation of dogs submitted to chemical castration. For this purpose, twelve dogs submitted to the administration of xylazine in subdosis in the yin-tang acupoint were used. After the establishment of sedation, the dogs were chemically neutered. The proposed protocol allowed chemical castration to be performed with comfort for the patient and the team of veterinarians. Therefore, it is concluded that the sedation protocol is safe and can be used in dogs for non-invasive procedures such as exams, material collection, and other similar processes or techniques.


Assuntos
Animais , Masculino , Cães , Xilazina/administração & dosagem , Analgesia por Acupuntura/veterinária , Cefalotina/administração & dosagem , Acupuntura/métodos , Meloxicam/administração & dosagem , Orquiectomia/métodos , Orquiectomia/veterinária
3.
Ciênc. Anim. (Impr.) ; 32(2): 17-27, abr.-jun. 2022. ilus
Artigo em Português | VETINDEX | ID: biblio-1402051

RESUMO

A orquiectomia consiste na remoção dos testículos e, em animais, pode ser realizada por motivo eletivo ou terapêutico. A cirurgia eletiva faz parte da guarda responsável de cães e gatos e é um dos procedimentos mais realizados na medicina veterinária, incluindo mutirões de castração onde a redução de custos é importante. A auto-hemoterapia (AHT) vem sendo aplicada em animais, inclusive em acupontos, com o intuito de produzir efeitos imunoestimulantes. Neste contexto, este estudo utilizou AHT, durante o período pós-operatório imediato, em acupontos de cães submetidos à orquiectomia eletiva sem a aplicação de antibióticos. Os resultados obtidos foram comparados com dados referentes a outro grupo de animais, os quais foram orquiectomizados e previamente tratados com antibiótico sistêmico. Todos os animais foram acompanhados clinicamente e foram feitos hemogramas nos períodos pré e pós-operatório, assim como o registro de infecções e outras intercorrências relacionadas ao procedimento cirúrgico. Considerando os 20 cães usados no estudo, não houve ocorrência de infecção ou processo inflamatório nos animais após o procedimento cirúrgico. Além disso, alterações hematológicas significativas não foram observadas entre os grupos e entre os períodos pré e pós-operatório de ambos os grupos. Desta forma, conclui-se que a auto-hemoterapia associada à acupuntura pode representar uma alternativa para um protocolo cirúrgico sem antibióticos em cirurgia eletiva de orquiectomia em animais hígidos.


The orchiectomy is the removal of the testicles and, in animals, can be performed due to by elective or therapeutic reasons. Elective surgery is part of the responsible ownership of dogs and cats and is one of the most performed procedures in veterinary medicine, including castration efforts where cost reduction is important. Autohemotherapy (AHT) has been applied in animals, including acupoints, to produce immunostimulatory effects. In this context, this study used AHT, during the immediate postoperative period, in acupoints of dogs submitted to elective orchiectomy without the use of antibiotics. The results obtained were compared to data from another group of animals, which were orchiectomized and previously treated with a systemic antibiotic. All animals were clinically monitored and hemograms were performed during the pre and post-operatory period, as well as the registration of infections and other complications related to the surgical procedure. Regarding the 20 dogs used in the study, there was no occurrence of infection or inflammation in the animals after the surgical procedure. In addition, significant hematologic alterations were not observed between groups and between pre- and post-operatory periods in both groups. Therefore, it is concluded that autohemotherapy associated with acupuncture may represent an alternative for a surgical protocol without antibiotics in elective orchiectomy surgery in healthy animals.


Assuntos
Animais , Masculino , Cães , Orquiectomia/veterinária , Pontos de Acupuntura , Auto-Hemoterapia/veterinária , Analgesia por Acupuntura/veterinária
4.
Odontol. Clín.-Cient ; 20(3): 36-40, jul.-set. 2021. ilus, tab
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1372314

RESUMO

Disfunção Temporomandibular (DTM) apresenta-se como principal causa de dores orofaciais de origem não dentária. A acupuntura é indicada para o alívio de da dor em casos de DTM muscular, baseada em propriedades anti-inflamatórias com efeitos neuro-hormonais. Objetivou-se nesta pesquisa a avaliação da eficácia da acupuntura como um método válido para redução imediata da sintomatologia dolorosa e limitação de abertura bucal nos casos de DTM. Realizou-se terapia acupuntural em 30 pacientes com DTM, avaliando-se a dor, a partir da Escala Verbal (EV) e da Escala Analógica Visual (EAV) e a limitação de abertura bucal com o auxílio de paquímetro digital antes e após a terapia para registro da análise. O aumento da média de abertura bucal foi de 9,2% no total de participantes. Quanto à sintomatologia dolorosa, apresentou redução média em 63%. Na EV, 27 dos pacientes tiveram resposta "moderada" e "intensa" para sensação dolorosa. Contudo, após a terapia, observou-se ausência de sensação dolorosa intensa. Os dados apontaram significância da terapia acupuntural para redução dor e limitação de abertura bucal, de forma imediata, em pacientes com DTM... (AU)


Temporomandibular Disorder (TMD) is the main cause of orofacial pain of non-dental origin. Acupuncture is indicated for pain relief in cases of muscle TMD, based on anti-inflammatory properties with neuro hormonal effects. The aim of this research was to evaluate the effectiveness of the acupuncture as a valid method for immediate reduction of painful symptoms and mouth opening limitation in TMD cases. Acupuncture therapy was performed in 30 patients with TMD, evaluating pain from the Verbal Scale (VE) and Visual Analog Scale (VAS) and mouth opening limitation with the aid of a digital caliper before and after therapy to record the analysis. The increase in the average mouth opening was 9.2% in the total number of participants. As for painful symptoms, an average reduction of 63%. In IV, 27 of the patients had "moderate" and "intense" responses to painful sensation. However, after therapy, the absence of intense painful sensation was observed. The data showed the significance of acupuncture therapy for immediate pain reduction and mouth opening limitation in patients with TMD... (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Dor Facial , Transtornos da Articulação Temporomandibular , Síndrome da Disfunção da Articulação Temporomandibular , Analgesia por Acupuntura , Terapia por Acupuntura , Acupuntura , Medicina Tradicional Chinesa , Boca , Músculos
5.
Pflugers Arch ; 473(4): 573-593, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33474636

RESUMO

The present study aims to describe state-of-the-art of preclinical studies that have investigated peripheral receptors and neuromediators involved in the antihyperalgesic effects of acupuncture. The PubMed, Scopus, and Web of Science databases were searched using the integrative review method. Preclinical articles that involved the study of peripheral receptors and neuromediators on the pain control effects of acupuncture in rats or mice were selected using a predefined search strategy. From this search, 456 articles were found, and 29 of them met the inclusion criteria of the study. The selected articles addressed the following peripheral receptors: opioid (n = 9), adenosine (n = 5), cannabinoid (n = 5), transient receptor potential vanilloid (TRPV) (n = 3), histamine (n = 2), adrenergic (n = 1), muscarinic (n = 1), corticotrophin-releasing factor (CRF) (n = 2), IL-1 (n = 1), and endothelin (n = 1) receptors. The peripheral neuromediators correlated with the peripheral pain control effect were as follows: opioid peptides (n = 4), adenosine (n = 3), histamine (n = 1), substance P (n = 1) calcitonin gene-related peptide (CGRP) (n = 1), anandamide (n = 1), nitric oxide (n = 1), and norepinephrine (n = 1). This review summarizes the methods used to investigate the peripheral effects of acupuncture and discusses the main findings on each family of receptors and neuromediators. Ten families of peripheral receptors and 8 types of neuromediators were correlated with the antihyperalgesic effects of acupuncture in preclinical studies. Considering the benefits of a better understanding of the role of peripheral receptors and neuromediators in the context pain management, the findings of the present study highlight the importance of deepening the exploration of the peripheral mechanisms of acupuncture.


Assuntos
Analgesia por Acupuntura/métodos , Neurotransmissores/metabolismo , Receptores de Neurotransmissores/metabolismo , Analgesia por Acupuntura/efeitos adversos , Animais , Humanos , Nociceptividade , Receptores Acoplados a Proteínas G/metabolismo
6.
Rev. enferm. neurol ; 19(2): 81-89, Sep-Dic. 2020.
Artigo em Espanhol | LILACS, BDENF - Enfermagem | ID: biblio-1253752

RESUMO

Introducción: la acupuntura humana es una terapia complementaria en la atención para la salud. Derivado de su alta demanda en gran parte del mundo la OMS fijo su postura a favor de la Medicina Tradicional y Complementaria (MTC) con la publicación "Estrategia sobre medicina tradicional 2014-2023", ésta se centra en dos objetivos: brindar apoyo a los Estados Miembros en la contribución de la MTC en la salud, bienestar y atención centrada en las personas y promover su utilización de forma segura y eficaz; mediante la reglamentación de productos, prácticas y profesionales capacitados. Desarrollo: la estrategia plantea la necesidad de que toda práctica de MTC sea realizada con formación universitaria, sin embargo, solo el 30% de los países miembros (39) cuentan con ella universitaria y 56% (72) tienen reglamentos para su práctica en acupuntura. En México se imparten diversos cursos y diplomados de MTC, a nivel técnico, licenciatura, especialidad y posgrado, con diferentes horas curriculares. Asimismo, cuenta con políticas de regulación sobre acupuntura y sus técnicas. Conclusión: la acupuntura tiene sustento científico en la anatomía y neurofisiología. Debe ser aplicada por profesionales del área de salud y con formación certificada por una institución de reconocido prestigio.


Assuntos
Humanos , Analgesia por Acupuntura , Terapêutica , Capacitação Profissional , Segurança do Paciente
7.
J Acupunct Meridian Stud ; 13(5): 147-151, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33049398

RESUMO

BACKGROUND: Nowadays, in western societies, acupuncture is widely used over the control of pain and this analgesic approach is still the most studied aspect of acupuncture. Several studies have shown that most patients go through a significant pain decrease soon after the first sessions of acupuncture. OBJECTIVES: This research has as a goal the evaluation on the effect of acupuncture treatment regarding the relief of pain intensity of different etiologies, through the visual analog scale. METHODS: This research constitutes a retrospective, descriptive study, carried out with 449 patients attended in the Institute Hospital de Base of the Federal District, in Brasilia city- Brazil. Every data was gathered from our own form, with detailed clinical history which included age, marital status, work activity, reason for referral to acupuncture, main and secondary complaints, pain intensity evaluated by the Visual Analog Scale (VAS), number of sessions completed and drug therapy. All data was organized in the Microsoft Excel and processed in the Statistical Package for the Social Sciences (SPSS), version 20.0. RESULTS: Regarding the main complaint, the mean pain decreased from 7.3 (initial VAS) to 3.2 (final VAS), a reduction that meant more than 50% relief in pain intensity. This 50% reduction in initial pain was also observed in secondary complaints (initial VAS = 6.5 and final VAS = 3.1). CONCLUSIONS: The results of this research suggest that acupuncture treatment was effective in relieving pain intensity, providing a 50% reduction on the visual analogue scale, in relation to painful complaints of different etiologies.


Assuntos
Analgesia por Acupuntura/métodos , Manejo da Dor/métodos , Adulto , Idoso , Brasil , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Centros de Atenção Terciária/estatística & dados numéricos
8.
Cochrane Database Syst Rev ; 9: CD011216, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32871021

RESUMO

BACKGROUND: Pain after caesarean sections (CS) can affect the well-being of the mother and her ability with her newborn. Conventional pain-relieving strategies are often underused because of concerns about the adverse maternal and neonatal effects. Complementary alternative therapies (CAM) may offer an alternative for post-CS pain. OBJECTIVES: To assess the effects of CAM for post-caesarean pain. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register, LILACS, PEDro, CAMbase, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform (ICTRP) (6 September 2019), and checked the reference lists of retrieved articles. SELECTION CRITERIA: Randomised controlled trials (RCTs), including quasi-RCTs and cluster-RCTs, comparing CAM, alone or associated with other forms of pain relief, versus other treatments or placebo or no treatment, for the treatment of post-CS pain. DATA COLLECTION AND ANALYSIS: Two review authors independently performed study selection, extracted data, assessed risk of bias and assessed the certainty of evidence using GRADE. MAIN RESULTS: We included 37 studies (3076 women) which investigated eight different CAM therapies for post-CS pain relief. There is substantial heterogeneity among the trials. We downgraded the certainty of evidence due to small numbers of women participating in the trials and to risk of bias related to lack of blinding and inadequate reporting of randomisation processes. None of the trials reported pain at six weeks after discharge. Primary outcomes were pain and adverse effects, reported per intervention below. Secondary outcomes included vital signs, rescue analgesic requirement at six weeks after discharge; all of which were poorly reported, not reported, or we are uncertain as to the effect Acupuncture or acupressure We are very uncertain if acupuncture or acupressure (versus no treatment) or acupuncture or acupressure plus analgesia (versus placebo plus analgesia) has any effect on pain because the quality of evidence is very low. Acupuncture or acupressure plus analgesia (versus analgesia) may reduce pain at 12 hours (standardised mean difference (SMD) -0.28, 95% confidence interval (CI) -0.64 to 0.07; 130 women; 2 studies; low-certainty evidence) and 24 hours (SMD -0.63, 95% CI -0.99 to -0.26; 2 studies; 130 women; low-certainty evidence). It is uncertain whether acupuncture or acupressure (versus no treatment) or acupuncture or acupressure plus analgesia (versus analgesia) has any effect on the risk of adverse effects because the quality of evidence is very low. Aromatherapy Aromatherapy plus analgesia may reduce pain when compared with placebo plus analgesia at 12 hours (mean difference (MD) -2.63 visual analogue scale (VAS), 95% CI -3.48 to -1.77; 3 studies; 360 women; low-certainty evidence) and 24 hours (MD -3.38 VAS, 95% CI -3.85 to -2.91; 1 study; 200 women; low-certainty evidence). We are uncertain if aromatherapy plus analgesia has any effect on adverse effects (anxiety) compared with placebo plus analgesia. Electromagnetic therapy Electromagnetic therapy may reduce pain compared with placebo plus analgesia at 12 hours (MD -8.00, 95% CI -11.65 to -4.35; 1 study; 72 women; low-certainty evidence) and 24 hours (MD -13.00 VAS, 95% CI -17.13 to -8.87; 1 study; 72 women; low-certainty evidence). Massage We identified six studies (651 women), five of which were quasi-RCTs, comparing massage (foot and hand) plus analgesia versus analgesia. All the evidence relating to pain, adverse effects (anxiety), vital signs and rescue analgesic requirement was very low-certainty. Music Music plus analgesia may reduce pain when compared with placebo plus analgesia at one hour (SMD -0.84, 95% CI -1.23 to -0.46; participants = 115; studies = 2; I2 = 0%; low-certainty evidence), 24 hours (MD -1.79, 95% CI -2.67 to -0.91; 1 study; 38 women; low-certainty evidence), and also when compared with analgesia at one hour (MD -2.11, 95% CI -3.11 to -1.10; 1 study; 38 women; low-certainty evidence) and at 24 hours (MD -2.69, 95% CI -3.67 to -1.70; 1 study; 38 women; low-certainty evidence). It is uncertain whether music plus analgesia has any effect on adverse effects (anxiety), when compared with placebo plus analgesia because the quality of evidence is very low. Reiki We are uncertain if Reiki plus analgesia compared with analgesia alone has any effect on pain, adverse effects, vital signs or rescue analgesic requirement because the quality of evidence is very low (one study, 90 women). Relaxation Relaxation may reduce pain compared with standard care at 24 hours (MD -0.53 VAS, 95% CI -1.05 to -0.01; 1 study; 60 women; low-certainty evidence). Transcutaneous electrical nerve stimulation TENS (versus no treatment) may reduce pain at one hour (MD -2.26, 95% CI -3.35 to -1.17; 1 study; 40 women; low-certainty evidence). TENS plus analgesia (versus placebo plus analgesia) may reduce pain compared with placebo plus analgesia at one hour (SMD -1.10 VAS, 95% CI -1.37 to -0.82; 3 studies; 238 women; low-certainty evidence) and at 24 hours (MD -0.70 VAS, 95% CI -0.87 to -0.53; 108 women; 1 study; low-certainty evidence). TENS plus analgesia (versus placebo plus analgesia) may reduce heart rate (MD -7.00 bpm, 95% CI -7.63 to -6.37; 108 women; 1 study; low-certainty evidence) and respiratory rate (MD -1.10 brpm, 95% CI -1.26 to -0.94; 108 women; 1 study; low-certainty evidence). We are uncertain if TENS plus analgesia (versus analgesia) has any effect on pain at six hours or 24 hours, or vital signs because the quality of evidence is very low (two studies, 92 women). AUTHORS' CONCLUSIONS: Some CAM therapies may help reduce post-CS pain for up to 24 hours. The evidence on adverse events is too uncertain to make any judgements on safety and we have no evidence about the longer-term effects on pain. Since pain control is the most relevant outcome for post-CS women and their clinicians, it is important that future studies of CAM for post-CS pain measure pain as a primary outcome, preferably as the proportion of participants with at least moderate (30%) or substantial (50%) pain relief. Measuring pain as a dichotomous variable would improve the certainty of evidence and it is easy to understand for non-specialists. Future trials also need to be large enough to detect effects on clinical outcomes; measure other important outcomes as listed lin this review, and use validated scales.


Assuntos
Cesárea/efeitos adversos , Terapias Complementares/métodos , Dor Pós-Operatória/terapia , Acupressão , Analgesia por Acupuntura , Adolescente , Adulto , Analgesia Obstétrica/métodos , Analgésicos/administração & dosagem , Aromaterapia , Viés , Terapia Combinada/métodos , Feminino , Humanos , Massagem , Musicoterapia , Placebos/uso terapêutico , Gravidez , Ensaios Clínicos Controlados Aleatórios como Assunto , Terapia de Relaxamento , Toque Terapêutico , Estimulação Elétrica Nervosa Transcutânea , Adulto Jovem
10.
PLoS One ; 15(4): e0231444, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32298300

RESUMO

Acupuncture is one of the therapeutic resources used for the management of chronic pain. Variability in outcome measurements in randomized clinical trials of non-oncologic chronic pain (RCT-NOCP) generates inconsistencies in determining effects of treatments. The objective of this survey was to assess the adherence to the recommendations made by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) in the measurement of RCT-NOCP of acupuncture. This methodological research made a systematic search for eligible studies from different sources of information. Eligible studies included those with number of patients ≥100, who randomized and allocated patients with chronic non-oncologic pain to be treated with acupuncture or with "sham" acupuncture, or non-acupuncture. This research included the recommendations for IMMPACT in the measurement of RCT-NOCP: presence of outcomes pain, physical function, emotional state and improvement perception of patient, the source of the outcome information pain and the tools used to measure such domains. From a total of 1,386 studies, 24 were included in this survey. Eleven studies presented low risk of bias. Pain outcome was measured in 23 studies, physical function in 22 studies, emotional state in 14 studies and improvement perception of patient in one study. As for the pain outcome, the patient was the information source in 50% of the studies. The measurement tools recommended for IMMPACT were included in eight studies (35%) that evaluated pain, one study that evaluated the emotional state (7%), and one study that evaluated the improvement perception and satisfaction of patient. It was observed that studies which did not adhere to the recommendations had more favorable results for acupuncture in the outcome pain. This study concludes that randomized clinical trials that used acupuncture to manage chronic pain failed to adhere to IMMPACT recommendations. Clinical societies and IMMPACT do not share the same recommendations. This fact reflects in the diversity of outcomes and instruments adopted in the studies, making it difficult to compare the results.


Assuntos
Analgesia por Acupuntura/métodos , Dor Crônica/terapia , Medição da Dor/métodos , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor/normas , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto/normas , Inquéritos e Questionários
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