RESUMO
Background: Prostate disease represents about 0.7% of diseases in canines. The main diagnosed pathology is benign prostatic hyperplasia (BPH). However, the reports that study the association of a certain clinical sign with a specific prostate disease are scarce. Aim: The main objective of this study was to evaluate the clinical relevance of the most commonly observed clinical signs associated with the different prostatic disorders in canines admitted to the hospital of the Facultad de Veterinaria-Universidad de la República between 2011 and 2019. Methods: This retrospective study included 7,729 male canines treated at the hospital de la Facultad de Veterinaria-Universidad de la República (Montevideo, Uruguay) between 2011 and 2019. 289 canines with a presumptive/definitive diagnosis of prostate diseases were selected, recording the presence/absence of associated clinical signs. Results were reported in terms of odds ratios (ORs) using logistic regression (p < 0.05). Results: The five most frequently reported clinical signs were tenesmus (34%), anorexia (32%), lethargy (27%), prostatomegaly or pain during rectal examination (25%), and abdominal pain from palpation (22%). Diarrhea (3.39 vs. 0.33 OR), anorexia (2.07 vs. 0.39 OR), weight loss (2.27 vs. 0.27 OR), hematuria (3.25 vs. 0.44 OR), and urinary incontinence (2.96 vs. 0.33 OR) indicated a highest predictive value (p < 0.05) with prostatitis versus BPH, respectively. Being weight loss, the clinical sign is more frequently associated with neoplasia (20.2 OR, p = 0.002). Conclusion: This study shows that there are clinical signs with a higher degree of association for certain canine prostatic disorders than others.
Assuntos
Doenças do Cão , Hiperplasia Prostática , Masculino , Animais , Cães , Hiperplasia Prostática/diagnóstico , Hiperplasia Prostática/epidemiologia , Hiperplasia Prostática/veterinária , Estudos Retrospectivos , Uruguai/epidemiologia , Anorexia/complicações , Anorexia/veterinária , Redução de Peso , Doenças do Cão/diagnóstico , Doenças do Cão/epidemiologiaRESUMO
O objetivo deste estudo é descrever o caso de mulher com síndrome de Meigs e apresentar a revisão narrativa sobre o tema. Paciente do sexo feminino, 30 anos, nulípara, encaminhada ao hospital por massa anexial e história prévia de drenagem de derrame pleural. Evoluiu com instabilidade hemodinâmica por derrame pleural hipertensivo à direita, sendo submetida a drenagem torácica, com citologia do líquido negativa. Após, foi submetida a laparotomia: realizada salpingo-ooforectomia esquerda. A congelação e a análise histopatológica diagnosticaram fibroma ovariano. A citologia ascítica foi negativa. CA-125 elevado, presença de derrames cavitários e exame de imagem suspeito podem mimetizar um cenário de neoplasia maligna de ovário em estágio avançado. Entretanto, na síndrome de Meigs clássica, o tratamento é cirúrgico, sendo o diagnóstico obtido por meio da análise histopatológica do tumor ovariano. O manejo da síndrome de Meigs clássica é cirúrgico e, após a remoção do tumor, o derrame pleural e a ascite desaparecem.
To describe a case of Meigs syndrome and present a narrative review of the condition. Female patient, 30 years old, nulliparous, referred to the hospital due to an adnexal mass and a previous drainage of pleural effusion. She developed hemodynamic instability due to a hypertensive right pleural effusion being submitted to chest drainage, with negative cytology of the fluid. She underwent laparotomy: Left salpingo-oophorectomy was performed and frozen section and histopathological analysis diagnosed an ovarian fibroma. Ascites cytology was negative. Elevated CA-125, presence of cavitary effusions, suspicious imaging exam can mimic a scenario of ovarian cancer at an advanced stage. However, in classical Meigs syndrome, treatment is surgical, and the diagnosis is obtained through histopathological analysis of the ovarian tumor. Classical Meigs syndrome' management is surgical. After tumor removal, pleural effusion and ascites resolve.
Assuntos
Humanos , Feminino , Adulto , Síndrome de Meigs/cirurgia , Síndrome de Meigs/diagnóstico , Relatos de Casos , Redução de Peso , Anorexia/complicações , Saúde da Mulher , Dor Pélvica , Tosse/complicações , Dispneia/complicações , Fadiga/complicações , Abdome/fisiopatologiaRESUMO
The objective of this study was to explore the relationship between intrinsic and extrinsic factors and a high cumulative score of the Basic Erosive Wear Examination (BEWE) in a Chilean adult group. A cross-sectional study was performed with the Ethics Committee's approval from the Universidad de los Andes. A consecutive adult (18 to 46 years old) sampling (n = 553) from the Health Center in San Bernardo-Chile, was selected from September 2016 to January 2017. Dental exams were performed by two trained and calibrated examiners, according to the BEWE index. In order to search for potentially related factors, a hetero-applied questionnaire previously developed and evaluated was applied. Our interest was individuals with severe erosion tooth wear (BEWE ≥ 14). Logistic regression models reporting crude odds ratio (OR) and adjusted OR by age, 95% confidence interval (95%CI), and p-values were estimated. Variables, odds ratios and 95% CI related with BEWE ≥ 14 were: age (OR 1.1 [1.07-1.14]); currently drinking alcohol (OR 1.59 [1.06-2.39]); esophagitis (OR 8.22 [1.60-42.22]); difficulty to swallow (OR 2.45 [1.10-5.44]); chest pain (OR 2.07 [1.18-3.64]); anorexia (OR 3.82 [1.07-13.68]); vitamin C intake (OR 1.92 [1.08-3.43]). Age, alcohol consumption, self-reported esophagitis, history of gastric symptoms, anorexia, and vitamin C intake were related as risk factors to high BEWE scores in this sample of Chilean adults in San Bernardo, Chile.
Assuntos
Esofagite , Erosão Dentária , Desgaste dos Dentes , Adulto , Humanos , Adolescente , Adulto Jovem , Pessoa de Meia-Idade , Estudos Transversais , Erosão Dentária/epidemiologia , Erosão Dentária/etiologia , Anorexia/complicações , Desgaste dos Dentes/complicações , Fatores de Risco , Esofagite/complicações , Ácido Ascórbico , PrevalênciaRESUMO
BACKGROUND & AIMS: Malnutrition in cancer is an independent factor associated with negative clinical outcomes. The aim was to evaluate the prevalence and independent risk factors for malnutrition in hospitalized cancer patients using the Patient-Generated Subjective Global Assessment (PG-SGA). METHODS: We evaluated 4783 cancer patients, aged ≥20 years, in a hospital-based, multicenter, cross-sectional study. Patients were classified as well-nourished (PG-SGA Stage A), moderate/suspected malnutrition (PG-SGA Stage B), or severely malnourished (PG-SGA Stage C), and provided a score to define required nutritional interventions. Multivariate analysis was composed of the odds ratio (OR) estimated by ordinal polytomous logistic regression. RESULTS: 45.3% were classified as Stage B and 11.8% as Stage C. Moreover, 45.3% of the patients presented a need for nutritional intervention. The variables that presented the highest ORs for Stage B or Stage C were: problems with swallowing (OR 2.8, 95% confidence interval (CI) 2.2-3.4, p < 0.001), loss of appetite (OR 1.9, 95% CI 1.6-2.3, p < 0.001), vomiting (OR 1.8, 95% CI 1.5-2.3, p < 0.001), presence of more than 3 nutrition impact symptoms (OR 8.3, 95% CI 5.8-12, p < 0.001), and cancer site: lung (OR 4.6, 95% CI 3.2-6.6, p < 0.001), upper digestive cancer (OR 3.7, 95% CI 2.7-5.2, p < 0.001), and head and neck cancer (OR 3.7, 95% CI 2.7-5.2, p < 0.001). The score for Worksheet 4 on the PG-SGA had a higher association with malnutrition (OR 7.3, 95% CI 6.6-8.2, p < 0.001). CONCLUSIONS: Malnutrition is highly prevalent in cancer patients in Brazil, and is associated with nutritional impact symptoms, cancer site and age ≥65 years.
Assuntos
Desnutrição , Neoplasias , Estado Nutricional/fisiologia , Adulto , Idoso , Anorexia/complicações , Anorexia/epidemiologia , Brasil , Estudos Transversais , Transtornos de Deglutição/complicações , Transtornos de Deglutição/epidemiologia , Diarreia/complicações , Diarreia/epidemiologia , Feminino , Hospitalização , Humanos , Masculino , Desnutrição/epidemiologia , Desnutrição/etiologia , Desnutrição/fisiopatologia , Pessoa de Meia-Idade , Neoplasias/complicações , Neoplasias/epidemiologia , Avaliação Nutricional , Vômito/complicações , Vômito/epidemiologiaRESUMO
El estilo de personalidad tendiente a los trastornos alimentarios se refiere a una lucha de sentido con el propio cuerpo, que regula la dialéctica entre la co-percepción del otro y el sentido de sí mismo, el problema alimentario va comprendido como un problema con la dialéctica del cuerpo, no con la imagen del cuerpo. El punto fundamental para comprender el trastorno alimentario es en relación a la imagen corporal, la mujer y los medios de información. Adicionalmente, se ha encontrado que la tecnología juega un papel importante al afectar no sólo la experiencia de la percepción, a través de acelerar el cambio en contextos específicos, sino la introducción de nuevos recursos de signi- ficado; nuevos puntos de referencia que proporcionan el anclaje para crear y mantener la identidad propia. Esto sitúa al hombre en una nueva forma de orientarse emocional- mente en relación a su contexto.
The eating disorder-prone style of personality refers to a feeling struggle with the same body, which regulates the dialectic between the other co-perception and the sense of self, the eating disorder is understood as a problem related to the dialectic of the body itself but not to the image of the body. The main point in order to understand the eating disorder is associated with the body image, the female gender and media. On the other hand, it has been found that technology plays a vital role not only by afecting the experience perception by accelerating the change in specific contexts but also by introducing new resources of meaning; new points of reference which provide the basis to create and keep the own identity. Thus, it sets the human in a new way of emotional orientation in relationship with his context.
Assuntos
Humanos , Transtornos da Alimentação e da Ingestão de Alimentos/psicologia , Personalidade , Autoimagem , Anorexia/complicações , Bulimia/complicações , InterocepçãoRESUMO
BACKGROUND: Anorexia-cachexia is a frequent syndrome among cancer patients, specially in late stages: the global prevalence of para-neoplastic anorexia-cachexia ranges between 20-40% in the diagnostic stage and between 70-80% in the late stage of the disease. The co-existence of functional or structural digestive abnormalities is frequently observed among cancer patients; this is a consequence of the tumor growth and of those systemic phenomena related to metabolism, which are affected by the relationship tumor-host specific to anorexia- cachexia. OBJECTIVE: This study aimed at establishing the frequency of anorexia-cachexia, as well as its relationship to GI symptoms in the context of palliative care patients at the Instituto Nacional de Cancerología, México City. METHODS AND MATERIAL: Analytic cross-sectional study including 100 patients diagnosed with late-stage cancer, age range 18-80, and a Karnofsky score > 50, as well as an ECOG <2; patients with a bad general health status were not allowed in the study. After reviewing inclusion and exclusion criteria, participants fulfilled the FAACT questionnaire, as well as the EGS. Patients recruitment was carried out by the Instituto Nacional de Cancerología. Results and discussion: Results show that 61% (n=61)of the patients had anorexia-cachexia, and 39% (n=39)did not. 56% of the sample participants (n=34) were women, and 44% (n=27) were men. GI symptoms associated with anorexia-cachexia were: nausea (p= 0.0001), vomiting (p=0.004), early satiety (p=0.0005), dysgeusia(p=0.0005) and dysphagia (p=0.001). CONCLUSION: Anorexia and cachexia are among the most devastating and frequent symptoms in late-stage cancer patients and they are also associated with GI symptoms affecting the physical, psychosocial and existential aspects of the patient's life. Data from this research validate the importance of an early nutrition support in palliative patients so that they can achieve a better quality of life.
Introducción: La anorexia-caquexia es un síndrome frecuente en pacientes oncológicos, particularmente en etapas avanzadas: la prevalencia global de anorexia-caquexia para-neoplásica oscila entre el 20-40% en los enfermos en la fase diagnóstica, y entre el 7080% en la fase avanzada de la enfermedad. En los enfermos oncológicos es frecuente la coexistencia de alteraciones digestivas estructurales o funcionales, secundarias al crecimiento tumoral y a los fenómenos sistémicos de carácter metabólico, determinados por la interrelación tumor-huésped específicos de la anorexia-caquexia. Objetivo: El objetivo de este trabajo es conocer la frecuencia de anorexia-caquexia, y su asociación con síntomas gastrointestinales en pacientes en terreno paliativo del Instituto Nacional de Cancerología, Ciudad de México, atendidos en el servicio de Cuidados Paliativos. Material y métodos: Se realizó un estudio transversal analítico. Se incluyeron 100 pacientes con diagnóstico de cáncer avanzado, con un rango de edad de 18 y 80 años, y una puntuación de Karnofsky > 50, así como un ECOG.
Assuntos
Anorexia/complicações , Anorexia/epidemiologia , Caquexia/complicações , Caquexia/epidemiologia , Gastroenteropatias/complicações , Gastroenteropatias/epidemiologia , Neoplasias/complicações , Academias e Institutos , Estudos Transversais , Feminino , Humanos , Masculino , México , Pessoa de Meia-Idade , Cuidados PaliativosRESUMO
The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states.
Assuntos
Sistema Nervoso Central/fisiologia , Metabolismo Energético , Homeostase , Hipotálamo/patologia , Animais , Anorexia/complicações , Anorexia/metabolismo , Anorexia/patologia , Humanos , Hipotálamo/metabolismo , Inflamação/complicações , Insulina/metabolismo , Leptina/metabolismo , Modelos Biológicos , Obesidade/complicações , Obesidade/metabolismo , Obesidade/patologia , Transdução de SinaisRESUMO
La anorexia y la bulimia son consideradas enfermedades modernas. El presente trabajo consiste en establecer los trastornos de la conducta alimentaria (anorexia y bulimia) y situaciones de riesgo en adolescentes del sexo femenino de 14 a 19 años de tercero de secundaria de dos establecimientos educativos, con escenarios distintos, colegio fiscal "Elena Arze de Arze" y el colegio particular "Instituto Americano".Es una investigación con enfoque cuantitativo; se aplicó un cuestionario que evaluó dos áreas importantes: criterios diagnósticos y situaciones de riesgo de adolescentes.Los resultados muestran que las estudiantes del "Instituto Americano" tienen más criterios de bulimia y las estudiantes del Colegio "Elena Arze de Arze" tienen más criterios de anorexia nerviosa. Entre los factores predisponentes a los trastornos de la alimentación, la insatisfacción con la imagen corporal de la madre del adolescente es la más frecuente en ambos colegios. Entre los factores precipitantes sólo las estudiantes del Colegio "Elena Arze de Arze" indican como factor la opinión de sus compañeros sobre ellas.
Assuntos
Adolescente , Anorexia/complicações , Anorexia/prevenção & controle , Bolívia , Bulimia/complicações , Saúde do Adolescente , Transtornos da Alimentação e da Ingestão de Alimentos/complicaçõesRESUMO
Conidiobolomycosis is an infection caused by fungi of the genus Conidiobolus spp. that is associated with a granulomatous rhinitis in humans and animals. In sheep, the disease is clinically characterized by respiratory changes, exophthalmia, craniofacial asymmetry, and fever. Microscopically, there are multifocal granulomas containing intralesional hyphae. For a long time, this disease was diagnosed as Enzootic Ethmoid Tumor. This report described three cases of conidiobolomycosis that had been previously diagnosed as Enzootic Ethmoid Tumor. Samples of nasal cavity, lung, parotid gland, and lymph node from three sheep submitted to histopathological examination in 1979 were retrieved in 2010 for a new histological, histochemical, and immunohistochemical evaluations. Paraffin-embedded tissue sections were stained with Hematoxylin-Eosin, Grocott's Metanamine Silver, and Periodic Acid Schiff. Immunohistochemistry was performed on paraffin embedded tissues using anti-cytokeratin primary antibody. Based on histopathology, histochemistry, and immunohistochemistry, the diagnosis of conidiobolomycosis was confirmed in three sheep, which had been previously diagnosed as Enzootic Ethmoid Tumor in 1979.(AU)