RESUMO
The appearance of new anti-tuberculosis drugs such as bedaquiline and delamanid makes it impossible not to remember that the first strictly controlled medical trials of tuberculosis treatment were published in two rigorously researched outstanding articles that can be qualified as historical. In 1948, streptomycin was formally studied as an efficacious anti-tuberculosis drug. In 1952, another trial compared streptomycin-paramino salicylic acid with isoniazid, by means of which the first bases of pharmacological tuberculosis treatment were established.
La aparición de nuevos fármacos antituberculosos, como la bedaquilina y el delaminid, hace inevitable recordar que los primeros ensayos estrictamente controlados del tratamiento médico de la tuberculosis se publicaron en dos artículos de excelente y rigurosa investigación científica que pueden calificarse como históricos. En 1948 se estudió formalmente la estreptomicina como medicamento antituberculoso eficaz. En 1952, en otro ensayo se comparó estreptomicina-ácido paraaminosalicílico con isoniacida, con lo que se establecieron las primeras bases del tratamiento farmacológico de la tuberculosis.
Assuntos
Antituberculosos/uso terapêutico , Desenvolvimento de Medicamentos/história , Tuberculose/tratamento farmacológico , Antituberculosos/história , História do Século XX , História do Século XXI , Humanos , Isoniazida/uso terapêutico , Ácido Salicílico/uso terapêutico , Estreptomicina/uso terapêuticoRESUMO
The incidence of leprosy in Governador Valadares, Brazil, in the 1980s spurred this town to pioneer the introduction of polychemotherapy. The aim of this research was to understand how the different actors involved in this context interacted, especially the employees and patients at the Special Public Health Service. To identify the territories that these interactions inevitably constituted, a variety of theoretical instruments were used, including dramatism (Burke) and performance (Turner). By taking a theatrical metaphor, we sought to find out the dynamics by which the different actors took the stage and established their most significant relationships in a dynamic process of constituted and reconstituted territories.
Assuntos
Antituberculosos/história , Política de Saúde/história , Hanseníase/história , Saúde Pública/história , Antituberculosos/uso terapêutico , Brasil , Quimioterapia Combinada/história , História do Século XX , Humanos , Hanseníase/tratamento farmacológicoAssuntos
Ginecologia/história , Tuberculose dos Genitais Femininos/história , Antituberculosos/história , Antituberculosos/uso terapêutico , Terapia Combinada , Diagnóstico por Imagem/história , Quimioterapia Combinada , Feminino , Procedimentos Cirúrgicos em Ginecologia/história , História do Século XX , Humanos , Distúrbios Menstruais/etiologia , México , Radioterapia/história , Tuberculose dos Genitais Femininos/complicações , Tuberculose dos Genitais Femininos/diagnóstico , Tuberculose dos Genitais Femininos/terapiaRESUMO
Paleopathologic findings provide strong evidence for the existence of tuberculosis in Andean populations of pre-Columbian America. Indirect evidence is available also to suggest its possible endemicity among some American Indian tribes who lived within the present-day contiguous United States before the arrival of Europeans. The available data suggest that tuberculosis became a major health problem in some tribes with increased population density and cultural changes after increased contact with European civilization, paralleling the deterioration in living conditions after relocation of the tribes to reservations. By 1900, tuberculosis had become one of the most serious health problems among North American Indians. Tuberculosis control was hampered by the lack of a specific treatment, and only the advent of specific chemotherapy in an ambulatory setting brought a breakthrough. Mortality, morbidity, and risk of infection have all sharply decreased over the past three decades. However, tuberculosis incidence rates among American Indians remain well above rates in the white population. An intensified effort to identify those with tuberculosis and those at risk of tuberculosis as well as to develop compliance-enhancing strategies with treatment regimens will be necessary to eliminate tuberculosis from Indian reservations.