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BACKGROUND: Pharmacobezoars are aggregates of undigested medications that accumulate in the gastrointestinal tract and can cause obstructive or toxic complications. In this paper, the first case is reported of a paediatric pharmacobezoar formation after a vitamin overdose. The objective of this report is to prevent the occurrence of this complication and the action to be taken. CLINIC CASE: A 6-year-old child, 6h after ingesting 40 chewable tablets of a hydrophobic vitamin E with high capacity to form a pharmacobezoar, underwent urgent oesophagogastroscopy. A viscoelastic mass of 10×4cm was observed stretching from the cardia to the greater curvature. Seventy-five percent of the mass was removed and the remainder was fragmented, hydrated and aspirated. The patient remains asymptomatic to date. CONCLUSIONS: An overdose of hydrophobic drugs can produce a bezoar formation therefore prompt evacuation is recommended with an upper gastrointestinal endoscopy, which is a safe and effective technique in gastric bezoars.

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O bezoar compreende o acúmulo de substâncias não-digeríveis (folhas, pêlos, pedras, produtos lácteos, medicamentos, entre outros) no trato digestório. Sua importância deve-se ao quadro clínico por vezes inespecífico e às complicações que podem surgir. Apresentamos aqui o caso de uma paciente de 62 anos atendida no serviço de Cirurgia Oncológica com quadro de um mês de evolução e suspeita inicial de neoplasia colorretal. Exames complementares não elucidaram o diagnóstico, que só foi feito após abordagem cirúrgica por laparotomia exploratória. Após a mesma, a paciente evoluiu com piora do estado geral e foi transferida para a UTI do hospital, falecendo devido a complicações septicêmicas. Esse caso demonstra as dificuldades para se chegar nesse diagnóstico e que o atraso pode resultar em complicações letais para o paciente.

Bezoar is a foreign body in the digestive tract originated from ingestion of non-digestible substances (leaves, hair, rocks, milk products, drugs, etc). Undetermined clinical signs and severe complications make it an important diagnosis. We report the case of a 62-year-old female patient who was seen at the oncological surgery department of Santa Casa de Misericórdia de Fortaleza. The patient reported having low gastrointestinal symptoms for a month. Colorectal neoplasia was initially suspected. Blood and image diagnostic tests were not elucidative. The diagnosis was just confirmed after surgical approach. The patient had a poor postoperative follow-up and died after complications of septicemia. This case demonstrates the difficulties to confirm such diagnosis and the lethal complications caused by diagnosis delay.

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Tricobezoares são corpos estranhos gástricos compostos por cabelos dos próprios pacientes. São mais comuns em crianças, principalmente do sexo feminino. Cursam freqüentemente com sintomas gastrintestinais como dor abdominal, náuseas, vômitos, anorexia, perda de peso e plenitude pós-prandial. Massa epigástrica, alopécia e antecedentes de tricofagia podem estarpresentes. O tratamento de eleição é o cirúrgico, acompanhado de tratamento psiquiátrico. Este trabalho tem como objetivo relatar três casos de pacientes com tricobezoar gástrico e realizar uma revisão da literatura. Todos os casos deste estudo eram de crianças dosexo feminino. Dois pacientes cursaram com quadro de suboclusão intestinal, apresentando dor abdominal evômitos. Em um caso havia dor abdominal não acompanhada por vômitos. Todos apresentaram antecedentes de tricofagia, bem como massa epigástrica palpável. Um com áreas de alopécia. O principal examede imagem empregado foi a seriografiaesofagogastroduodenal. Todos foram submetidos a tratamento cirúrgico mediante gastrotomia e encaminhados para serviço de psicologia, com boaevolução clínica.

Trichobezoars are concretions of ingested hair that most often lodge in the stomach. They are commonlyseen in young girls with psychiatric disorders. Upper gastrointestinal symptoms usually are progressive andmay include abdominal pain, nausea and vomiting, early satiety, weight loss, bloating, diarrhea or constipation. Ahistory of tricophagia is common. Physical examination may include the presence of nontender palpable massand bald spot. Gastric trichobezoars require removal through an anterior gastrotomy. Postoperatively, psychiatric intervention is often appropriate. The purpose of this study was to describe three cases of patients with gastric trichobezoar and make a review of literature. All patients studied were yo ung girls. Two patients presented abdominal pain and vomiting. In one case there was abdominal pain without vomiting. All cases presented tricophagia and palpable mass. One had bald spot. Barium contrast study was the most beneficial in the diagnosis. In our cases, bezoars were removed easily via single gastrotomy. Postoperatively they were evaluated by psychology. The remainder of their hospital course wasunremarkable.

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BACKGROUND: There is little information available concerning trichobezoars in the non-human primate literature. METHODS: We evaluated 118 cases of trichobezoar in baboons over a 29-year period at the Southwest National Primate Research Center. RESULTS: The anatomic locations affected in decreasing order were the stomach, small intestine, cecum, esophagus and colon. The most common clinical history was weight loss. The most frequent associated pathology included gastrointestinal inflammation and ulceration, emaciation, peritonitis, intussusception, pneumonia, and aspiration. Trichobezoars were the cause of death in nine baboons and the reason for euthanasia in 12. Females were 2.14 times more likely than males to be affected. The greater the percentage of group housing time, the more likely the baboon is to develop trichobezoars. CONCLUSIONS: The baboon may present a useful model to evaluate the etiology, genetic predisposition, physiopathology, neurobiology, and treatment response of trichobezoars.

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