Assuntos
Carcinoma de Célula de Merkel/secundário , Neoplasias Hepáticas/secundário , Fosfatidilinositol 3-Quinases/genética , Inibidores de Fosfoinositídeo-3 Quinase , Inibidores de Proteínas Quinases/uso terapêutico , Purinas/uso terapêutico , Quinazolinonas/uso terapêutico , Neoplasias Cutâneas/patologia , Idoso de 80 Anos ou mais , Antineoplásicos/uso terapêutico , Carcinoma de Célula de Merkel/tratamento farmacológico , Carcinoma de Célula de Merkel/genética , Linhagem Celular Tumoral , Classe I de Fosfatidilinositol 3-Quinases , Feminino , Humanos , Fígado/diagnóstico por imagem , Neoplasias Hepáticas/tratamento farmacológico , Estadiamento de Neoplasias , Fosfatidilinositol 3-Quinases/metabolismo , Radiografia , CintilografiaRESUMO
Merkel cell carcinoma (MCC) is recognized by its morphologic features and by its classic immunophenotypic properties. Although MCCs demonstrating nonclassic immunoreactivities have been described, a case documenting a change in immunophenotype during the course of disease progression has not been previously reported. We report a case of MCC that initially demonstrated cytokeratin 20 positivity but lost expression in subsequent metastases. Likewise, thyroid transcription factor-1 was initially negative in the tumor but expression was present in metastatic lesions.
Assuntos
Biomarcadores Tumorais/análise , Neoplasias Encefálicas/química , Neoplasias Encefálicas/secundário , Carcinoma de Célula de Merkel/química , Carcinoma de Célula de Merkel/secundário , Proteínas Nucleares/análise , Neoplasias Cutâneas/química , Fatores de Transcrição/análise , Idoso , Biópsia , Neoplasias Encefálicas/terapia , Carcinoma de Célula de Merkel/terapia , Progressão da Doença , Humanos , Imuno-Histoquímica , Queratina-20/análise , Masculino , Valor Preditivo dos Testes , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/terapia , Fator Nuclear 1 de TireoideRESUMO
Merkel cell carcinoma (MCC) is a rare tumor of neuroendocrine origin. It is a highly invasive and aggressive neoplasia, that frequently presents regional and distant metatases. Therefore, there is high mortality associated with it. This report presents two male patients, one sixty three years and the other eighty eight years of age, with MCC of the cheek and invasive metastatic lesions to the head and neck areas. One of the patients died of associated distant metastatic disease and the other patient died of comorbid conditions present at time of tumor excision.