Assuntos
Ovos/efeitos adversos , Hipersensibilidade/etiologia , Vacina contra Sarampo/efeitos adversos , Vacina contra Caxumba/efeitos adversos , Vacina contra Rubéola/efeitos adversos , Criança , Combinação de Medicamentos/efeitos adversos , Humanos , Hipersensibilidade/diagnóstico , Vacina contra Sarampo-Caxumba-Rubéola , Testes CutâneosRESUMO
A placebo-controlled study of varicella vaccine given either with or 6 weeks after measles-mumps-rubella (MMR) vaccine was undertaken in healthy children (mean age 16 months). A total of 101 varicella-zoster virus antibody-negative children completed the study. Serologic response to MMR vaccine was excellent (nearly 100%) and not significantly affected by the administration of varicella vaccine. Seroconversion in response to varicella vaccine was excellent and was not affected by MMR vaccine. No significant differences in fever or skin rashes between those receiving MMR vaccine with varicella vaccine or MMR vaccine with placebo were noted, but fever and skin rashes were more frequent after the first immunization (MMR with varicella vaccine or MMR vaccine with placebo) compared with the second (varicella vaccine or placebo injection). Symptoms of fatigue, irritability, and upper respiratory tract infections were more common after MMR vaccine was given regardless of whether it was given simultaneously with varicella vaccine or placebo injection.
Assuntos
Herpesvirus Humano 3/imunologia , Vacina contra Sarampo/administração & dosagem , Vacina contra Caxumba/administração & dosagem , Vacina contra Rubéola/administração & dosagem , Vacinas Virais/administração & dosagem , Anticorpos Antivirais/análise , Vacina contra Varicela , Dermatite/etiologia , Método Duplo-Cego , Combinação de Medicamentos/administração & dosagem , Combinação de Medicamentos/efeitos adversos , Eritema/etiologia , Feminino , Febre/etiologia , Humanos , Esquemas de Imunização , Lactente , Masculino , Vacina contra Sarampo/efeitos adversos , Vacina contra Sarampo-Caxumba-Rubéola , Vacina contra Caxumba/efeitos adversos , Otite Média/epidemiologia , Distribuição Aleatória , Vacina contra Rubéola/efeitos adversos , Vacinas Virais/efeitos adversosRESUMO
A retrospective epidemiologic study examining the relationship of the time of onset of neurologic disorders with the time of pertussis immunization in two cohorts of children who received pertussis immunization at different ages is reported. Before April 1970, children in Denmark were vaccinated with diphtheria and tetanus toxoids with pertussis vaccine at 5, 6, 7, and 15 months of age. Since 1970, children were given monovalent pertussis vaccine at 5 and 9 weeks and at 10 months of age. A total of 554 cases of epilepsy with onset between 28 days and 24 months of age were reviewed, 286 from the 1967-1968 period and 268 from the 1972-1973 period. There was no relationship between the age of onset of epilepsy and the scheduled age of administration of pertussis vaccine. A total of 2199 children with febrile seizures were reviewed, 830 from the 1967-1968 period and 1369 from the 1972-1973 period. There was a statistical association between first febrile seizures and the scheduled age of administration of pertussis vaccine (p = 0.004). No relationship between pertussis immunization and the occurrence of central nervous system infections was noted.
Assuntos
Encefalopatias/etiologia , Vacina contra Coqueluche/efeitos adversos , Fatores Etários , Toxoide Diftérico/efeitos adversos , Vacina contra Difteria, Tétano e Coqueluche , Combinação de Medicamentos/efeitos adversos , Epilepsia/etiologia , Humanos , Esquemas de Imunização , Lactente , Meningite/etiologia , Meningoencefalite/etiologia , Estudos Retrospectivos , Convulsões/etiologia , Toxoide Tetânico/efeitos adversosAssuntos
Ovos/efeitos adversos , Hipersensibilidade Alimentar , Vacina contra Sarampo/efeitos adversos , Vacina contra Caxumba/efeitos adversos , Vacina contra Rubéola/efeitos adversos , Pré-Escolar , Combinação de Medicamentos/administração & dosagem , Combinação de Medicamentos/efeitos adversos , Humanos , Lactente , Testes Intradérmicos , Vacina contra Sarampo/administração & dosagem , Vacina contra Sarampo-Caxumba-Rubéola , Vacina contra Caxumba/administração & dosagem , Vacina contra Rubéola/administração & dosagem , SegurançaRESUMO
Six patients died suddenly following the administration of radio contrast media. All had received the so-called older agents which are being replaced by newer contrast agents, which are characterized by reduced osmolality. Five of the six patients experienced almost immediate difficulty in breathing followed by death.
Assuntos
Meios de Contraste/efeitos adversos , Morte Súbita/etiologia , Adulto , Idoso , Diatrizoato/efeitos adversos , Diatrizoato de Meglumina/efeitos adversos , Combinação de Medicamentos/efeitos adversos , Feminino , Fluoresceína , Fluoresceínas/efeitos adversos , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A double-blind randomized clinical trial was conducted at two sites comparing amoxicillin-clavulanate potassium (Augmentin) and amoxicillin trihydrate for the treatment of otitis media with effusion ("secretory otitis media"). One hundred eight subjects were randomly assigned to receive a ten-day course of either drug regimen. Clinical response was assessed at ten days and four weeks after entry. For those without middle ear effusion at four weeks, recurrence rates were measured at 8, 12, and 16 weeks after entry. At ten days following entry, 29 (51.8%) of 56 subjects in the amoxicillin-clavulanate-treated group were effusion free compared with 16 (32.0%) of 50 subjects in the amoxicillin-treated group (P = .06). At four weeks following entry, 26 (50.0%) of 50 subjects in the amoxicillin-clavulanate-treated group were effusion free compared with 23 (51.1%) of 45 subjects in the group given amoxicillin. By the 16-week visit, eight (36.4%) of 22 subjects in the amoxicillin-clavulanate-treated group who were effusion free at four weeks had recurrence of effusion, compared with 12 (63.2%) of 19 subjects in the amoxicillin-treated group. This study suggests that there was a favorable clinical response immediately following treatment in the amoxicillin-clavulanate--treated subjects as compared with those treated with amoxicillin, but this benefit was not sustained at the four-week end point.