Assuntos
Sporothrix , Esporotricose , Animais , Antifúngicos/uso terapêutico , Glicosaminoglicanos/análise , Humanos , Itraconazol/uso terapêutico , Dermatoses da Perna/tratamento farmacológico , Dermatoses da Perna/microbiologia , Dermatoses da Perna/patologia , Masculino , Pessoa de Meia-Idade , Micoses/diagnóstico , Micoses/tratamento farmacológico , Micoses/patologia , Patologia Molecular , Sporothrix/efeitos dos fármacos , Sporothrix/isolamento & purificação , Esporotricose/diagnóstico , Esporotricose/tratamento farmacológico , Esporotricose/patologiaRESUMO
Most black fungi that are repeatedly involved in human infection belong to the order Chaetothyriales. Capnodialean melanized fungi often thrive in extreme environments like rock surfaces and hypersaline microhabitats. They are able to grow meristematically with very thick cellular walls, resembling muriform cells of agents of chromoblastomycosis. In this report we describe a member of the order Capnodiales causing a chromoblastomycosis-like infection in human skin. However, in tissue the fungus presented with toruloid hyphae and intercalary, chlamydospore-like conidia with transversal septa, rather than with muriform cells. Judging from ITS rRNA sequences, the fungus is related to, but clearly different from, the genera Catenulostroma and Pseudotaeniolina; members of these genera are environmental and only rarely occur on human hosts.
Assuntos
Ascomicetos/isolamento & purificação , Cromoblastomicose/microbiologia , Dermatomicoses , Diagnóstico Diferencial , Dermatoses da Perna , Ascomicetos/classificação , Ascomicetos/crescimento & desenvolvimento , Cromoblastomicose/diagnóstico , Dermatomicoses/diagnóstico , Dermatomicoses/microbiologia , Humanos , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/microbiologia , Masculino , Pessoa de Meia-Idade , Pele/microbiologiaRESUMO
Chromoblastomycosis is one of the most frequent infections caused by melanized fungi. It is a subcutaneous fungal infection, usually an occupational related disease, mainly affecting individuals in tropical and temperate regions. Although several species are etiologic agents, Fonsecaea pedrosoi and Cladophialophora carrionii are prevalent in the endemic areas. Chromoblastomycosis lesions are polymorphic and must be differentiated from those associated with many clinical conditions. Diagnosis is confirmed by the observation of muriform cells in tissue and the isolation and the identification of the causal agent in culture. Chromoblastomycosis still is a therapeutic challenge for clinicians due to the recalcitrant nature of the disease, especially in the severe clinical forms. There are three treatment modalities, i.e., physical treatment, chemotherapy and combination therapy but their success is related to the causative agent, the clinical form and severity of the chromoblastomycosis lesions. There is no treatment of choice for this neglected mycosis, but rather several treatment options. Most of the patients can be treated with itraconazole, terbinafine or a combination of both. It is also important to evaluate the patient's individual tolerance of the drugs and whether the antifungal will be provided for free or purchased, since antifungal therapy must be maintained in long-term regimens. In general, treatment should be guided according to clinical, mycological and histopathological criteria.
Assuntos
Ascomicetos , Cromoblastomicose , Dermatoses da Mão , Dermatoses da Perna , Idoso , Antifúngicos/administração & dosagem , Antifúngicos/uso terapêutico , Ascomicetos/classificação , Ascomicetos/genética , Ascomicetos/isolamento & purificação , Cromoblastomicose/diagnóstico , Cromoblastomicose/microbiologia , Cromoblastomicose/patologia , Cromoblastomicose/terapia , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/microbiologia , Dermatoses da Mão/patologia , Dermatoses da Mão/terapia , Humanos , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/microbiologia , Dermatoses da Perna/patologia , Dermatoses da Perna/terapia , MasculinoRESUMO
Lobomycosis is a common subcutaneous mycosis in South America. It is caused by Lacazia loboi. We report two cases of lobomycosis which were diagnosed by exfoliative cytology without any special staining. We highlight this diagnostic tool as a simple, low-cost, painless, non-invasive and fast method for the diagnosis of lobomycosis.
Assuntos
Citodiagnóstico , Dermatomicoses/diagnóstico , Dermatoses da Perna/diagnóstico , Onygenales/isolamento & purificação , Pele/microbiologia , Adulto , Brasil , Dermatomicoses/microbiologia , Dermatomicoses/patologia , Humanos , Dermatoses da Perna/microbiologia , Dermatoses da Perna/patologia , Masculino , Pessoa de Meia-Idade , Onygenales/classificação , Fatores de TempoRESUMO
We describe a patient with mycetoma or Madura foot, in which histopathological stains of the bone and surface cultures suggested three different organisms including Nocardia species as the cause. Criteria for the diagnosis of the organisms, differentiation between colonizer and pathogen, and significance of mixed infections are discussed.
Assuntos
Dermatoses do Pé/microbiologia , Dermatoses da Perna/microbiologia , Micetoma/microbiologia , Anti-Infecciosos/uso terapêutico , Doença Crônica , Doxiciclina/uso terapêutico , Dermatoses do Pé/tratamento farmacológico , Dermatoses do Pé/patologia , Humanos , Dermatoses da Perna/tratamento farmacológico , Dermatoses da Perna/patologia , Masculino , Pessoa de Meia-Idade , Micetoma/tratamento farmacológico , Micetoma/patologia , Combinação Trimetoprima e Sulfametoxazol/uso terapêuticoRESUMO
We describe a patient with mycetoma or Madura foot, in which histopathological stains of the bone and surface cultures suggested three different organisms including Nocardia species as the cause. Criteria for the diagnosis of the organisms, differentiation between colonizer and pathogen, and significance of mixed infections are discussed.
Descrevemos um paciente com micetoma ou maduromicose de pé, no que colorações histopatológicos de osso e de culturas superficiais sugeriram três organismos diferentes, incluindo espécies de Nocardia como causador. Os critérios de diagnóstico dos organismos, a diferenciação entre colonizador e patógeno, e a significância das infecções mistas são discutidos.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Dermatoses do Pé/microbiologia , Dermatoses da Perna/microbiologia , Micetoma/microbiologia , Anti-Infecciosos/uso terapêutico , Doença Crônica , Doxiciclina/uso terapêutico , Dermatoses do Pé/tratamento farmacológico , Dermatoses do Pé/patologia , Dermatoses da Perna/tratamento farmacológico , Dermatoses da Perna/patologia , Micetoma/tratamento farmacológico , Micetoma/patologia , Combinação Trimetoprima e Sulfametoxazol/uso terapêuticoRESUMO
We report the case of a one-day-old newborn infant, female, birth weight 1900 g, gestational age 36 weeks presenting with necrotizing fasciitis caused by E. coli and Morganella morganii. The newborn was allowed to fall into the toilet bowl during a domestic delivery. The initial lesion was observed at 24 hours of life on the left leg at the site of the venipuncture for the administration of hypertonic glucose solution. Despite early treatment, a rapid progression occurred resulting in a fatal outcome. We call attention to the risk presented by this serious complication in newborns with a contaminated delivery, and highlight the site of the lesion and causal agents.
Assuntos
Fasciite Necrosante/microbiologia , Parto Domiciliar , Dermatoses da Perna/microbiologia , Escherichia coli , Fasciite Necrosante/patologia , Evolução Fatal , Feminino , Humanos , Recém-Nascido , Dermatoses da Perna/patologia , Morganella morganiiRESUMO
Nocardia brasiliensis is recognized in the United States as an infectious agent of the skin that may present as an abscess, ulcer, or granuloma with or without "sporotrichoid" spread, and rarely causes systemic disease. Treatment with trimethoprim/sulfamethoxazole is usually curative. We present a patient with multiple erythematous, painful, draining nodules that developed thirty-six months after trauma and subsequent contamination with soil in Bermuda. A foreign body granuloma was suspected clinically, and excision was performed followed by recurrence of the lesions. Histologic examination and culture were consistent with nocardiosis. Differential diagnosis of foreign body granulomas also should include infection with N. brasiliensis even after a long incubation period. Culture and drug susceptibility testing of affected tissue should be performed for diagnosis and management.
Assuntos
Corpos Estranhos/diagnóstico , Granuloma/diagnóstico , Dermatoses da Perna/diagnóstico , Nocardiose/diagnóstico , Dermatopatias Bacterianas/diagnóstico , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Dermatoses da Perna/microbiologia , Dermatopatias Bacterianas/microbiologia , Microbiologia do SoloAssuntos
Infecções Oportunistas Relacionadas com a AIDS/patologia , Dermatoses da Perna/microbiologia , Escroto/microbiologia , Tinha dos Pés/patologia , Tinha/patologia , Adulto , Doenças dos Genitais Masculinos/microbiologia , Doenças dos Genitais Masculinos/patologia , Humanos , Dermatoses da Perna/patologia , Masculino , Microsporum/isolamento & purificação , Escroto/patologiaRESUMO
In this paper the authors study the sites of single lesions in 317 paucibacillary patients registered at the outpatient units of the CMS Jorge Saldanha and the Curupaiti State Hospital in Rio de Janeiro, Brazil. The preferential sites of lesions in the population studied, their relation with age and sex and factors likely to influence their distribution are discussed. The findings are compared with other similar studies performed in Asia and Africa.