RESUMO
The precise segmentation of white blood cells (WBCs) within blood smear images is a significant challenge with implications for both medical research and image processing. Of particular importance is the often neglected task of accurately segmenting WBC nuclei, an aspect that currently lacks dedicated methodologies. This paper introduces a straightforward and efficient method designed to fill this critical gap, providing an effective solution for the efficient segmentation of WBC nuclei. In blood smear imagery, the distinctive coloration of WBCs contrasts with the hues of other blood components. The inherent obscurity of WBCs prompts their segmentation by isolating pixels with minimal intensities. To streamline this process, our proposed method employs the Laplacian pyramid technique to decorrelate pixels in blood smear images, thereby amplifying the contrast. Subsequently, the intensities of pixels constituting blood cells, encompassing WBCs and the background, are modeled using three Gaussian random variables. Capitalizing on this feature, we implement the Gaussian mixture model (GMM) clustering method to determine the optimal threshold value, facilitating a highly precise segmentation of WBC nuclei. The proposed method demonstrates the capability to process images containing a single WBC as well as effectively functioning with images containing multiple cells of this type. Evaluation of the method on the ALL-IDB, ALL-IDB2, CellaVision, and JTSC datasets yielded accuracy values of 0.9802, 0.9725, 0.9772, and 0.9730, respectively. Comparative analysis with state-of-the-art methods revealed a notably comparable performance, underscoring the effectiveness of the proposed approach. The method presented in this article is highly competitive for segmenting the nuclei of WBCs compared to state-of-the-art methods. The three main advantages of our method are its ability to process images containing one or more WBCs, the automatic calculation of threshold values for each processed image, eliminating the need for manual parameter adjustments. Lastly, the method is efficient, as its algorithmic complexity is approximately O ( n m ) .
Assuntos
Algoritmos , Núcleo Celular , Processamento de Imagem Assistida por Computador , Leucócitos , Humanos , Leucócitos/citologia , Distribuição Normal , Processamento de Imagem Assistida por Computador/métodos , Análise por ConglomeradosRESUMO
OBJECTIVE: Interindividual similarity refers to how similarly individuals respond when receiving the same stimulus or intervention. In this study, we aimed to examine interindividual similarity in adults with ADHD. METHOD: We used the cosine similarity index of ex-Gaussian reaction time (RT) vectors of mu, sigma, and tau parameters during a Stroop task. RESULTS: Our results demonstrate that the ADHD group exhibits a reduced interindividual similarity index in their ex-Gaussian RT vectors for congruent stimuli compared to the healthy control group. Importantly, we did not find significant differences in the interindividual similarity index to incongruent stimuli between both groups, thus suggesting that this reduced index was selective for congruent stimuli. CONCLUSION: Our findings highlight that ADHD adults exhibit more significant interindividual differences in cognitive functioning when processing congruent stimuli than healthy controls. These results provide new insights into the selective mechanisms underlying ADHD and may contribute to developing new targeted interventions for this disorder.
Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Adulto , Humanos , Tempo de Reação , Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Distribuição Normal , Cognição , Teste de StroopRESUMO
Purkinje cells exhibit a reduction of the mean firing rate at intermediate-noise intensities, which is somewhat reminiscent of the response enhancement known as "stochastic resonance" (SR). Although the comparison with the stochastic resonance ends here, the current phenomenon has been given the name "inverse stochastic resonance" (ISR). Recent research has demonstrated that the ISR effect, like its close relative "nonstandard SR" [or, more correctly, noise-induced activity amplification (NIAA)], has been shown to stem from the weak-noise quenching of the initial distribution, in bistable regimes where the metastable state has a larger attraction basin than the global minimum. To understand the underlying mechanism of the ISR and NIAA phenomena, we study the probability distribution function of a one-dimensional system subjected to a bistable potential that has the property of symmetry, i.e., if we change the sign of one of its parameters, we can obtain both phenomena with the same properties in the depth of the wells and the width of their basins of attraction subjected to Gaussian white noise with variable intensity. Previous work has shown that one can theoretically determine the probability distribution function using the convex sum between the behavior at small and high noise intensities. To determine the probability distribution function more precisely, we resort to the "weighted ensemble Brownian dynamics simulation" model, which provides an accurate estimate of the probability distribution function for both low and high noise intensities and, most importantly, for the transition of both behaviors. In this way, on the one hand, we show that both phenomena emerge from a metastable system where, in the case of ISR, the global minimum of the system is in a state of lower activity, while in the case of NIAA, the global minimum is in a state of increased activity, the importance of which does not depend on the width of the basins of attraction. On the other hand, we see that quantifiers such as Fisher information, statistical complexity, and especially Shannon entropy fail to distinguish them, but they show the existence of the mentioned phenomena. Thus, noise management may well be a mechanism by which Purkinje cells find an efficient way to transmit information in the cerebral cortex.
Assuntos
Neurônios , Ruído , Processos Estocásticos , Neurônios/fisiologia , Funções Verossimilhança , Distribuição NormalRESUMO
The conventional approach to data-driven inversion framework is based on Gaussian statistics that presents serious difficulties, especially in the presence of outliers in the measurements. In this work, we present maximum likelihood estimators associated with generalized Gaussian distributions in the context of Rényi, Tsallis and Kaniadakis statistics. In this regard, we analytically analyze the outlier-resistance of each proposal through the so-called influence function. In this way, we formulate inverse problems by constructing objective functions linked to the maximum likelihood estimators. To demonstrate the robustness of the generalized methodologies, we consider an important geophysical inverse problem with high noisy data with spikes. The results reveal that the best data inversion performance occurs when the entropic index from each generalized statistic is associated with objective functions proportional to the inverse of the error amplitude. We argue that in such a limit the three approaches are resistant to outliers and are also equivalent, which suggests a lower computational cost for the inversion process due to the reduction of numerical simulations to be performed and the fast convergence of the optimization process.
Assuntos
Algoritmos , Funções Verossimilhança , Distribuição NormalRESUMO
The estimation of physical parameters from data analyses is a crucial process for the description and modeling of many complex systems. Based on Rényi α-Gaussian distribution and patched Green's function (PGF) techniques, we propose a robust framework for data inversion using a wave-equation based methodology named full-waveform inversion (FWI). From the assumption that the residual seismic data (the difference between the modeled and observed data) obeys the Rényi α-Gaussian probability distribution, we introduce an outlier-resistant criterion to deal with erratic measures in the FWI context, in which the classical FWI based on l2-norm is a particular case. The new misfit function arises from the probabilistic maximum-likelihood method associated with the α-Gaussian distribution. The PGF technique works on the forward modeling process by dividing the computational domain into outside target area and target area, where the wave equation is solved only once on the outside target (before FWI). During the FWI processing, Green's functions related only to the target area are computed instead of the entire computational domain, saving computational efforts. We show the effectiveness of our proposed approach by considering two distinct realistic P-wave velocity models, in which the first one is inspired in the Kwanza Basin in Angola and the second in a region of great economic interest in the Brazilian pre-salt field. We call our proposal by the abbreviation α-PGF-FWI. The results reveal that the α-PGF-FWI is robust against additive Gaussian noise and non-Gaussian noise with outliers in the limit α â 2/3, being α the Rényi entropic index.
Assuntos
Ruído , Entropia , Distribuição Normal , ProbabilidadeRESUMO
Huxley's model of simple allometry provides a parsimonious scheme for examining scaling relationships in scientific research, resource management, and species conservation endeavors. Factors including biological error, analysis method, sample size, and overall data quality can undermine the reliability of a fit of Huxley's model. Customary amendments enhance the complexity of the power function-conveyed systematic term while keeping the usual normality-borne error structure. The resulting protocols bear multiple-parameter complex allometry forms that could pose interpretative shortcomings and parameter estimation difficulties, and even being empirically pertinent, they could potentially bear overfitting. A subsequent heavy-tailed Q-Q normal spread often remains undetected since the adequacy of a normally distributed error term remains unexplored. Previously, we promoted the advantages of keeping Huxley's model-driven systematic part while switching to a logistically distributed error term to improve fit quality. Here, we analyzed eelgrass leaf biomass and area data exhibiting a marked size-related heterogeneity, perhaps explaining a lack of systematization at data gathering. Overdispersion precluded adequacy of the logistically adapted protocol, thereby suggesting processing data through a median absolute deviation scheme aimed to remove unduly replicates. Nevertheless, achieving regularity to Huxley's power function-like trend required the removal of many replicates, thereby questioning the integrity of a data cleaning approach. But, we managed to adapt the complexity of the error term to reliably identify Huxley's model-like systematic part masked by variability in data. Achieving this relied on an error term conforming to a normal mixture distribution which successfully managed overdispersion in data. Compared to normal-complex allometry and data cleaning composites present arrangement delivered a coherent Q-Q normal mixture spread and a remarkable reproducibility strength of derived proxies. By keeping the analysis within Huxley's original theory, the present approach enables substantiating nondestructive allometric proxies aimed at eelgrass conservation. The viewpoint endorsed here could also make data cleaning unnecessary.
Assuntos
Modelos Biológicos , Biomassa , Distribuição Normal , Folhas de Planta , Reprodutibilidade dos Testes , Tamanho da AmostraRESUMO
The nonlinear dynamics of a FitzHugh-Nagumo (FHN) neuron driven by an oscillating current and perturbed by a Gaussian noise signal with different intensities D is investigated. In the noiseless case, stable periodic structures [Arnold tongues (ATS), cuspidal and shrimp-shaped] are identified in the parameter space. The periods of the ATSs obey specific generating and recurrence rules and are organized according to linear Diophantine equations responsible for bifurcation cascades. While for small values of D, noise starts to destroy elongations ("antennas") of the cuspidals, for larger values of D, the periodic motion expands into chaotic regimes in the parameter space, stabilizing the chaotic motion, and a transient chaotic motion is observed at the periodic-chaotic borderline. Besides giving a detailed description of the neuronal dynamics, the intriguing novel effect observed for larger D values is the generation of a regular dynamics for the driven FHN neuron. This result has a fundamental importance if the complex local dynamics is considered to study the global behavior of the neural networks when parameters are simultaneously varied, and there is the necessity to deal the intrinsic stochastic signal merged into the time series obtained from real experiments. As the FHN model has crucial properties presented by usual neuron models, our results should be helpful in large-scale simulations using complex neuron networks and for applications.
Assuntos
Modelos Neurológicos , Neurônios , Redes Neurais de Computação , Neurônios/fisiologia , Dinâmica não Linear , Distribuição NormalRESUMO
Many authors have been working on approaches that can be applied to social robots to allow a more realistic/comfortable relationship between humans and robots in the same space. This paper proposes a new navigation strategy for social environments by recognizing and considering the social conventions of people and groups. To achieve that, we proposed the application of Delaunay triangulation for connecting people as vertices of a triangle network. Then, we defined a complete asymmetric Gaussian function (for individuals and groups) to decide zones where the robot must avoid passing. Furthermore, a feature generalization scheme called socialization feature was proposed to incorporate perception information that can be used to change the variance of the Gaussian function. Simulation results have been presented to demonstrate that the proposed approach can modify the path according to the perception of the robot compared to a standard A* algorithm.
Assuntos
Robótica , Algoritmos , Simulação por Computador , Humanos , Distribuição Normal , Robótica/métodos , Interação SocialRESUMO
This article extends the semiparametric mixed model for longitudinal censored data with Gaussian errors by considering the Student's t $$ t $$ -distribution. This model allows us to consider a flexible, functional dependence of an outcome variable over the covariates using nonparametric regression. Moreover, the proposed model takes into account the correlation between observations by using random effects. Penalized likelihood equations are applied to derive the maximum likelihood estimates that appear to be robust against outlying observations with respect to the Mahalanobis distance. We estimate nonparametric functions using smoothing splines under an EM-type algorithm framework. Finally, the proposed approach's performance is evaluated through extensive simulation studies and an application to two datasets from acquired immunodeficiency syndrome clinical trials.
Assuntos
Síndrome da Imunodeficiência Adquirida , Síndrome da Imunodeficiência Adquirida/terapia , Simulação por Computador , Humanos , Funções Verossimilhança , Modelos Estatísticos , Distribuição Normal , EstudantesRESUMO
Brazil has an extensive coastline and Exclusive Economic Zone (EEZ) area, which are of high economic and strategic importance. A Maritime Surveillance System becomes necessary to provide information and data to proper authorities, and target tracking is crucial. This paper focuses on a multitarget tracking application to a large-scale maritime surveillance system. The system is composed of a sensor network distributed over an area of interest. Due to the limited computational capabilities of nodes, the sensors send their tracking data to a central station, which is responsible for gathering and processing information obtained by the distributed components. The local Multitarget Tracking (MTT) algorithm employs a random finite set approach, which adopts a Gaussian mixture Probability Hypothesis Density (PHD) filter. The proposed data fusion scheme, utilized in the central station, consists of an additional step of prune & merge to the original GM PHD filter algorithm, which is the main contribution of this work. Through simulations, this study illustrates the performance of the proposed algorithm with a network composed of two stationary sensors providing the data. This solution yields a better tracking performance when compared to individual trackers, which is attested by the Optimal Subpattern Assignment (OSPA) metric and its location and cardinality components. The presented results illustrate the overall performance improvement attained by the proposed solution. Moreover, they also stress the need to resort to a distributed sensor network to tackle real problems related to extended targets.