Assuntos
Toxinas Botulínicas Tipo A/efeitos adversos , Técnicas Cosméticas/efeitos adversos , Doenças Labiais/induzido quimicamente , Fármacos Neuromusculares/efeitos adversos , Idoso , Blefaroptose/induzido quimicamente , Abrasão Química/efeitos adversos , Dermatite de Contato/complicações , Dermatoses Faciais/complicações , Feminino , Humanos , Inflamação/etiologia , Lasers de Estado Sólido/efeitos adversos , Pessoa de Meia-Idade , Fotoquimioterapia/efeitos adversos , Distúrbios da Fala/induzido quimicamenteRESUMO
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). All-trans retinoic acid (ATRA) is the first-choice therapy for the treatment of this disease, but has been associated with side effects, the most serious of which is retinoic acid syndrome (RAS). RAS is characterized by unexplained fever, dyspnea, pulmonary infiltrate, leukocytosis and nephropathy. Genital ulcers have been described in some cases, but only two cases of oral ulcers related to this syndrome have been described in the literature. This paper describes the third case of oral ulceration related to ATRA in a 32-year-old white man with diagnosis of APL. Clinicians should know the side effects of ATRA and identify oral ulcers resulting from this therapy. The prompt identification of these ulcers enables the institution of appropriate treatment and can therefore contribute to continuation of the patient's cancer treatment.
Assuntos
Antineoplásicos/efeitos adversos , Leucemia Promielocítica Aguda/tratamento farmacológico , Doenças Labiais/induzido quimicamente , Tretinoína/efeitos adversos , Úlcera/induzido quimicamente , Adulto , Humanos , MasculinoRESUMO
Antimalarial drugs, like chloroquine, may produce hyperpigmentation of the oral mucosa, affecting most commonly the palate. Its pathogenesis is not clear; an increased production of melanin is currently believed to be the cause of this oral manifestation. The purpose of this study was to report a case of atypical oral mucosal hyperpigmentation secondary to antimalarial therapy. A 66-year-old, dark skinned woman was evaluated for oral pigmentation. The patient had a history of chloroquine therapy, and presented a diffuse blue-gray pigmentation in the hard palate and, mainly, in the lower lip. Diagnostic hypothesis were of physiologic pigmentation, drug-induced pigmentation, pigmentation associated with systemic diseases, smoker's melanosis and post-inflammatory pigmentation. Incisional biopsy was conducted and histopathological examination revealed lichenoid dermatitis and pigment incontinence. Fontana-Masson staining was positive for melanin, but Perl's iron staining was negative. The histopathological diagnosis was consistent with melanin incontinence related to drug-induced lichenoid reaction secondary to chloroquine therapy. Adequate correlation of clinical and microscopic aspects was essential for the definitive diagnosis, especially in atypical cases. This diagnosis is of great relevance for the patient, since the oral manifestation might be an early sign of ocular complications due to antimalarial therapy. Therefore, the identification of these oral manifestations indicates regular evaluations by an ophtalmologist, preventing greater complications of antimalarial therapy for the patient.
Assuntos
Antimaláricos/efeitos adversos , Cloroquina/efeitos adversos , Erupções Liquenoides/induzido quimicamente , Doenças Labiais/induzido quimicamente , Idoso , Feminino , Humanos , Erupções Liquenoides/patologia , Doenças Labiais/patologiaRESUMO
BACKGROUND: Oral mucositis is the main complication of chemotherapy and radiotherapy used in the treatment of cancer. Phototherapy has proven effective in the treatment of mucositis, as it accelerates the tissue healing process and has both analgesic and anti-inflammatory properties. CASE REPORT: This paper reports the case of a paediatric patient with oral mucositis stemming from chemotherapy employed for the treatment of acute lymphoblastic leukaemia. TREATMENT: The lesions were treated daily with a light-emitting diode (LED). FOLLOWUP: Remission of the lesions occurred after 10 days of treatment. CONCLUSIONS: LED was effective in the treatment of mucositis, as it diminished pain symptoms and accelerated the tissue repair process.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Terapia com Luz de Baixa Intensidade/métodos , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Estomatite/induzido quimicamente , Analgesia , Anti-Inflamatórios , Celulite (Flegmão)/induzido quimicamente , Celulite (Flegmão)/radioterapia , Pré-Escolar , Feminino , Dermatoses da Mão/induzido quimicamente , Dermatoses da Mão/radioterapia , Humanos , Lasers Semicondutores/uso terapêutico , Doenças Labiais/induzido quimicamente , Doenças Labiais/radioterapia , Úlceras Orais/induzido quimicamente , Úlceras Orais/radioterapia , Medição da Dor , Indução de Remissão , Estomatite/radioterapia , Doenças da Língua/induzido quimicamente , Doenças da Língua/radioterapia , Cicatrização/efeitos da radiaçãoRESUMO
Hydroxyurea (HU) is an antimetabolic agent commonly used in myeloproliferative disorders and hematological diseases as well as in severe psoriasis. Despite of usually be well tolerated, sometimes it can induce immunosuppression and mucocutaneous adverse effects associated with discomfort or pain. Nevertheless, oral mucosal adverse reactions are extremely uncommon and present as ulcers, tongue depapilation and dyschromia. Complete remission of adverse effects is usually observed after withdrawal of the medication. The aim of this paper is to report two patients with oral lesions related to HU treatment. T0 he patients were adequately managed by changing hydroxyurea with imatinib mesilate. Oral lesions are rare complications of long-term hydroxyurea treatment and may be an indication of stopping therapy and substitution with imatinib mesilate.
Assuntos
Antineoplásicos/efeitos adversos , Hidroxiureia/efeitos adversos , Doenças da Boca/induzido quimicamente , Adolescente , Adulto , Benzamidas , Doenças da Gengiva/induzido quimicamente , Humanos , Mesilato de Imatinib , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Doenças Labiais/induzido quimicamente , Masculino , Soalho Bucal/efeitos dos fármacos , Mucosa Bucal/efeitos dos fármacos , Úlceras Orais/induzido quimicamente , Piperazinas/uso terapêutico , Pirimidinas/uso terapêutico , Doenças da Língua/induzido quimicamenteRESUMO
AIM: A case is reported in which sodium hypochlorite (NaOCl) was mistaken for anaesthetic solution and infiltrated into the buccal mucosa during routine root canal treatment. SUMMARY: A 1.5% sodium hypochlorite solution, kept in an anaesthetic cartridge, was inadvertently injected in the buccal mucosa of a 56-year-old female during routine root canal treatment. Soft tissue necrosis, labial ptosis and paraesthesia occurred shortly after the injection. Tissues healed with scarring and lip paraesthesia persisted for 3 years. KEY LEARNING POINTS: * NaOCl is highly irritant when introduced into oral tissues. * NaOCl solutions should not be kept in anaesthetic cartridges. * Accidents with NaOCl should be carefully assessed and when appropriate active hospital treatment should be sought. * Early recognition of NaOCl accidents may avert potentially more serious outcomes.