RESUMO
Objective. To present 4 new cases of oral leiomyomatous hamartomas (OLH), describing its clinical, microscopical, and immunohistochemical features, and a literature review. Methods. The OLH cases were retrieved from the files of 2 Brazilian and 1 Peruvian oral pathology services. Clinical data were obtained from the pathology reports. Microscopical features were reviewed, and immunohistochemical reactions were performed. A review of the English-language literature about OLH was done. Results. The sample was composed of 3 females (4-, 10-, and 15-year-old) and 1 male (3-year-old). Three cases affected the dorsum of the tongue and one the incisive papilla, and all presented sessile or pedunculated smooth nodules. Microscopically, the lesions were composed of varying-size fascicles of smooth muscle fibers in a fibrous connective tissue background. Immunohistochemistry revealed positivity of the smooth muscle bundles for myogenic markers. The English-language literature review revealed 38 OLH cases reported, most were congenital or diagnosed up to 5 years old. The main locations were tongue and anterior maxilla. Conclusions. Although OLH is a rare lesion, it must be considered in the differential diagnosis of midline tongue or maxillary masses in newborns, infants, and youngsters.
Assuntos
Gengiva/patologia , Doenças da Gengiva/diagnóstico , Hamartoma/diagnóstico , Doenças da Língua/diagnóstico , Língua/patologia , Adolescente , Fatores Etários , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Gengiva/cirurgia , Doenças da Gengiva/congênito , Doenças da Gengiva/cirurgia , Hamartoma/congênito , Hamartoma/cirurgia , Humanos , Imuno-Histoquímica , Masculino , Maxila , Língua/cirurgia , Doenças da Língua/congênito , Doenças da Língua/cirurgiaAssuntos
Melanose/patologia , Doenças da Língua/patologia , Adulto , Biópsia , Feminino , Humanos , Melanose/congênito , Doenças Raras , Doenças da Língua/congênitoAssuntos
Humanos , Feminino , Adulto , Doenças da Língua/patologia , Melanose/patologia , Doenças da Língua/congênito , Biópsia , Doenças Raras , Melanose/congênitoRESUMO
Mucoceles are benign lesions of the oral cavity that develop as a result of retention or extravasation of mucous material from minor salivary glands. Congenital mucoceles are very rare. These lesions in newborns may interfere with breastfeeding and may even compromise respiratory function. A patient with a congenital mucocele diagnosed by prenatal ultrasound screening showing a cystic lesion of the tongue is presented herein. The physical examination, lesion evolution and imaging are described, together with the surgical management, histopathology and two-year follow-up. Early clinical assessment, differential diagnosis and magnetic resonance imaging allow clinicians to diagnose and treat this rare congenital condition with surgery in early infancy.
Assuntos
Mucocele/congênito , Doenças da Língua/congênito , Língua/patologia , Diagnóstico Diferencial , Humanos , Recém-Nascido , Imageamento por Ressonância Magnética , Masculino , Mucocele/diagnóstico , Doenças da Língua/diagnósticoRESUMO
Ankyloglossia is an anomaly that is characterized by the abnormal insertion of the lingual frenulum that hinders protrusion and elevation of the tongue towards the palate, due to the short and thick composition of the frenulum. In babies it can cause inefficient nursing at the mother's breast, inadequate transfer of milk and pain in the mother's breast, resulting in early weaning and weight loss. An 8-month-old baby boy was brought to the clinic by his mother because he found it difficult to suck and consequently avoiding breast feeding, and was apparently losing weight. During the clinical exam it was observed that the patient presented little mobility of the tongue. Owing to the degree of ankyloglossia and the features of malnutrition present, it was decided to carry out complete removal of the frenulum under general anesthesia. Although this procedure might increase the risk of morbidity, the possibility of recurrence and the need to perform further procedures are avoided; the main advantage is reducing aggravation of the clinical problems.
Assuntos
Aleitamento Materno , Insuficiência de Crescimento/etiologia , Freio Lingual/cirurgia , Procedimentos Cirúrgicos Bucais/métodos , Doenças da Língua/cirurgia , Insuficiência de Crescimento/terapia , Humanos , Lactente , Freio Lingual/anormalidades , Masculino , Comportamento de Sucção , Doenças da Língua/congênito , Resultado do TratamentoRESUMO
Ankyloglossia is a congenital oral anomaly characterized by the presence of a hypertrophic lingual frenulum. It frequently accompanies X-linked cleft palate and is sometimes seen alone due to mutations in the gene encoding the transcription factor TBX22, while knockout of Lgr5 in the mouse results in ankyloglossia. The aim of the present study was to characterize the phenotype and to verify sequence variations in the LGR5 gene in a Brazilian family with ankyloglossia associated with tooth number anomalies. Twelve individuals of three generations were submitted to physical, oral, and radiographic examinations and molecular analysis. Eight had ankyloglossia with various degrees of severity. Six also had hypodontia in the lower incisor region; one had a supernumerary tooth in this region, and another had a supernumerary tooth in the lower premolar region. The characterization of this family determined an autosomal-dominant inheritance and excluded the LGR5 gene mutations as being involved in the pathogenesis of this condition.
Assuntos
Anodontia/complicações , Freio Lingual/anormalidades , Receptores Acoplados a Proteínas G/genética , Doenças da Língua/genética , Dente Supranumerário/complicações , Anodontia/genética , Brasil , Análise Mutacional de DNA , Feminino , Genes Dominantes , Humanos , Masculino , Mutação , Linhagem , Receptores Acoplados a Proteínas G/deficiência , Doenças da Língua/complicações , Doenças da Língua/congênito , Dente Supranumerário/genética , Adulto JovemAssuntos
Hamartoma/patologia , Doenças da Língua/patologia , Actinas/análise , Diagnóstico Diferencial , Feminino , Hamartoma/congênito , Humanos , Técnicas Imunoenzimáticas , Leiomioma/diagnóstico , Mesenquimoma/diagnóstico , Pessoa de Meia-Idade , Miócitos de Músculo Liso/patologia , Proteínas S100/análise , Doenças da Língua/congênitoRESUMO
A 12-year-old girl presented with three yellowish polypoid lesions in the lateral border of tongue since birth. Histological examination showed oral mucosa covered by squamous epithelium and an underlying vascularized fibrous stroma, containing small and short bundles of striated muscle, corresponding to a rhabdomyomatous hamartoma.